Alkaloid Production in Catharanthus Roseus Cell Cultures. XINRCC 20086. For part X see [1]. Biotransformation of 3′, 4′-Anhydrovinblastine to Other Bisindole Alkaloids
Kutney, James P. ; Aweryn, Barbara ; Choi, Lewis S. L. ; Kolodziejczyk, Pawel ; Kurz, Wolfgang G. W. ; Chatson, Kenneth B. ; Constabel, Friedrich
New York, NY : Wiley-Blackwell
Published 1982
New York, NY : Wiley-Blackwell
Published 1982
| ISSN: |
0018-019X
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|---|---|
| Keywords: |
Chemistry ; Organic Chemistry
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| Source: |
Wiley InterScience Backfile Collection 1832-2000
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| Topics: |
Chemistry and Pharmacology
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| Notes: |
Biotransformation studies of 3′,4′-anhydrovinblastine (1) in Calharanthus roseus cell suspension cultures are reported. A detailed study of one cell line, coded at „916“, has revealed that 1 is transformed to the natural bisindole alkaloids leurosine (2) and Catharine (3) in approximately 25-30 and 9-16% yield, respectively. In 24-48 h, about 40% of 1 is utilized by the cells. Conditions for biotransformation of 1 have not been optimized so the above yields quoted are not final.
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| Additional Material: |
7 Tab.
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| Type of Medium: |
Electronic Resource
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| URL: |