Alkaloid Production in Catharanthus roseus Cell Cultures. VII.For Part VI, see [1].. Effect of parameter changes and catabolism studies on cell line PRL No. 953
Kutney, James P. ; Choi, Lewis S. L. ; Kolodziejczyk, Pawel ; Sleigh, Stephen K. ; Stuart, Kenneth L. ; Worth, Brian R. ; Kurz, Wolfgang G. W. ; Chatson, Kenneth B. ; Constabel, Friedrich
New York, NY : Wiley-Blackwell
Published 1981
New York, NY : Wiley-Blackwell
Published 1981
| ISSN: |
0018-019X
|
|---|---|
| Keywords: |
Chemistry ; Organic Chemistry
|
| Source: |
Wiley InterScience Backfile Collection 1832-2000
|
| Topics: |
Chemistry and Pharmacology
|
| Notes: |
Catharanthus roseus cells suspended in production medium showed the presence of four Aspidosperma-type alkaloids, however, no vindoline. Cells grown in media with the pH adjusted to 7.0 produced 3.3 mg total alkaloids/g dry weight. At pH 5.0, 1.7 mg of alkaloid/g dry weight was produced. (S)-Adenosyl-methionine did not stimulate the production of vindoline. When added to cell suspensions for 21 days, vindoline and catharanthine were degraded to non-alkaloidal substances, not dimerized to bisindole alkaloids.
|
| Additional Material: |
3 Tab.
|
| Type of Medium: |
Electronic Resource
|
| URL: |