Conversion of Natural (S)-Bulbocapnine into Two (Ring A)-Substituted Derivatives of (R)-ApomorphinePresented by A. B. at the 10th European Symposium on Bio-Organic Chemistry, Gregyonog Hall, Wales (U.K.), May 14th to 17th, 1976, and during a lecture tour in Japan (autumn 1976).
| ISSN: |
0018-019X
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| Keywords: |
Chemistry ; Organic Chemistry
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| Source: |
Wiley InterScience Backfile Collection 1832-2000
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| Topics: |
Chemistry and Pharmacology
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| Notes: |
(6aR)-1,2-(Methylenedioxy)aporphine-10, 11-diol (8) and (6aR)-aporphine-1, 1, 10, 11-tetrol (16) have been prepared from natural (S)-bulbocapnine (4). For both compounds, the partial synthesis included racemic intermediates which have been resolved into their enantiomers. Both compounds 8 and 16 showed dopaminergic activity in rats, although to a lower extent than (R)-apomorphine (1) itself.
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| Additional Material: |
1 Tab.
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| Type of Medium: |
Electronic Resource
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| URL: |