The evaluation of a biphasic calcium phosphate ceramic for use in grafting long-bone diaphyseal defects
| ISSN: |
0736-0266
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| Keywords: |
Hydroxyapatite ; Bone graft ; Nonunion ; Life and Medical Sciences
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| Source: |
Wiley InterScience Backfile Collection 1832-2000
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| Topics: |
Medicine
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| Notes: |
The effectiveness of a sintered hydroxyapatite-tricalcium phosphate (HA-TCP) ceramic in bridging large diaphyseal defects in the canine ulna was studied. One-hundred percent morselized HA-TCP, a 50:50 mixture of morselized HA-TCP, and autogenous cancellous bone, and 100% autogenous cancellous bone were used to bridge 2.5-cm defects in the left ulnae of three groups of six dogs each. At 24 weeks the ulnae were explanted and studied by radiography, microradiography, mechanical testing, and histology. Pure HA/TCP was not osteoinductive, and four of six ulnae in this group progressed to a fibrous nonunion. The HA/TCP-cancellous bone mixture and pure cancellous bone were approximately equal in effect, leading to good callus formation at 4 weeks and strong bony union by 24 weeks, with no evidence of bioincompatibility. Morselized HA/TCP promises to be useful as a graft extender when mixed with autogenous cancellous bone.
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| Additional Material: |
6 Ill.
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| Type of Medium: |
Electronic Resource
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| URL: |