The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides.
| ISSN: |
0006-3525
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|---|---|
| Keywords: |
Chemistry ; Polymer and Materials Science
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| Source: |
Wiley InterScience Backfile Collection 1832-2000
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| Topics: |
Chemistry and Pharmacology
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| Notes: |
A comparative study on the proton magnetic resonance of the dinucleoside monophosphates TpT, dApT, TpdA, the trinucleoside diphosphates dApTpT, TpTpdA, and poly T has been made. The purpose of this investigation was to establish whether in a trimer the proton chemical shifts of one terminal residue are influenced by the magnetic anistropy of the other terminal residue. The conformation of the trimers was first studied and shown to the similar to that of the corresponding dimer, except that of the percentage of the lefthanded conformers in the population of the trimers is probably lower than in the population of the dimers. The methylprotons, H-6, and H-1′ of the 3′-terminal T residue in TpTpdA (or the 5′-terminal T residue in dApTpT) are found to be more upfield than the same protons on the dimer TpT up to a magnitude of about 0.1 ppm. The shielding of these protons of the terminal T(s) in these trimers is even larger than those corresponding protons in the poly(T) at the same condition. From these results, it is concluded that a distant shielding effect is exerted by the 5′-terminal. A residue (or by the 3′-terminal A residue) on the other terminal residue in the trimers studied.
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| Additional Material: |
2 Ill.
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| Type of Medium: |
Electronic Resource
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| URL: |
| _version_ | 1798297878282633218 |
|---|---|
| addmaterial | 2 Ill. |
| autor | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. |
| autorsonst | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. |
| book_url | http://dx.doi.org/10.1002/bip.1973.360121018 |
| datenlieferant | nat_lic_papers |
| hauptsatz | hsatz_simple |
| identnr | NLM159549531 |
| iqvoc_descriptor_keyword | iqvoc_00000092:Materials |
| issn | 0006-3525 |
| journal_name | Biopolymers |
| materialart | 1 |
| notes | A comparative study on the proton magnetic resonance of the dinucleoside monophosphates TpT, dApT, TpdA, the trinucleoside diphosphates dApTpT, TpTpdA, and poly T has been made. The purpose of this investigation was to establish whether in a trimer the proton chemical shifts of one terminal residue are influenced by the magnetic anistropy of the other terminal residue. The conformation of the trimers was first studied and shown to the similar to that of the corresponding dimer, except that of the percentage of the lefthanded conformers in the population of the trimers is probably lower than in the population of the dimers. The methylprotons, H-6, and H-1′ of the 3′-terminal T residue in TpTpdA (or the 5′-terminal T residue in dApTpT) are found to be more upfield than the same protons on the dimer TpT up to a magnitude of about 0.1 ppm. The shielding of these protons of the terminal T(s) in these trimers is even larger than those corresponding protons in the poly(T) at the same condition. From these results, it is concluded that a distant shielding effect is exerted by the 5′-terminal. A residue (or by the 3′-terminal A residue) on the other terminal residue in the trimers studied. |
| package_name | Wiley-Blackwell |
| publikationsjahr_anzeige | 1973 |
| publikationsjahr_facette | 1973 |
| publikationsjahr_intervall | 8029:1970-1974 |
| publikationsjahr_sort | 1973 |
| publikationsort | New York |
| publisher | Wiley-Blackwell |
| reference | 12 (1973), S. 2409-2421 |
| schlagwort | Chemistry Polymer and Materials Science |
| search_space | articles |
| shingle_author_1 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. |
| shingle_author_2 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. |
| shingle_author_3 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. |
| shingle_author_4 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. |
| shingle_catch_all_1 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. Chemistry Polymer and Materials Science Chemistry Polymer and Materials Science A comparative study on the proton magnetic resonance of the dinucleoside monophosphates TpT, dApT, TpdA, the trinucleoside diphosphates dApTpT, TpTpdA, and poly T has been made. The purpose of this investigation was to establish whether in a trimer the proton chemical shifts of one terminal residue are influenced by the magnetic anistropy of the other terminal residue. The conformation of the trimers was first studied and shown to the similar to that of the corresponding dimer, except that of the percentage of the lefthanded conformers in the population of the trimers is probably lower than in the population of the dimers. The methylprotons, H-6, and H-1′ of the 3′-terminal T residue in TpTpdA (or the 5′-terminal T residue in dApTpT) are found to be more upfield than the same protons on the dimer TpT up to a magnitude of about 0.1 ppm. The shielding of these protons of the terminal T(s) in these trimers is even larger than those corresponding protons in the poly(T) at the same condition. From these results, it is concluded that a distant shielding effect is exerted by the 5′-terminal. A residue (or by the 3′-terminal A residue) on the other terminal residue in the trimers studied. 0006-3525 00063525 Wiley-Blackwell |
| shingle_catch_all_2 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. Chemistry Polymer and Materials Science Chemistry Polymer and Materials Science A comparative study on the proton magnetic resonance of the dinucleoside monophosphates TpT, dApT, TpdA, the trinucleoside diphosphates dApTpT, TpTpdA, and poly T has been made. The purpose of this investigation was to establish whether in a trimer the proton chemical shifts of one terminal residue are influenced by the magnetic anistropy of the other terminal residue. The conformation of the trimers was first studied and shown to the similar to that of the corresponding dimer, except that of the percentage of the lefthanded conformers in the population of the trimers is probably lower than in the population of the dimers. The methylprotons, H-6, and H-1′ of the 3′-terminal T residue in TpTpdA (or the 5′-terminal T residue in dApTpT) are found to be more upfield than the same protons on the dimer TpT up to a magnitude of about 0.1 ppm. The shielding of these protons of the terminal T(s) in these trimers is even larger than those corresponding protons in the poly(T) at the same condition. From these results, it is concluded that a distant shielding effect is exerted by the 5′-terminal. A residue (or by the 3′-terminal A residue) on the other terminal residue in the trimers studied. 0006-3525 00063525 Wiley-Blackwell |
| shingle_catch_all_3 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. Chemistry Polymer and Materials Science Chemistry Polymer and Materials Science A comparative study on the proton magnetic resonance of the dinucleoside monophosphates TpT, dApT, TpdA, the trinucleoside diphosphates dApTpT, TpTpdA, and poly T has been made. The purpose of this investigation was to establish whether in a trimer the proton chemical shifts of one terminal residue are influenced by the magnetic anistropy of the other terminal residue. The conformation of the trimers was first studied and shown to the similar to that of the corresponding dimer, except that of the percentage of the lefthanded conformers in the population of the trimers is probably lower than in the population of the dimers. The methylprotons, H-6, and H-1′ of the 3′-terminal T residue in TpTpdA (or the 5′-terminal T residue in dApTpT) are found to be more upfield than the same protons on the dimer TpT up to a magnitude of about 0.1 ppm. The shielding of these protons of the terminal T(s) in these trimers is even larger than those corresponding protons in the poly(T) at the same condition. From these results, it is concluded that a distant shielding effect is exerted by the 5′-terminal. A residue (or by the 3′-terminal A residue) on the other terminal residue in the trimers studied. 0006-3525 00063525 Wiley-Blackwell |
| shingle_catch_all_4 | Kan, Lou S. Barrett, J. C. Ts'O, P. O. P. The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. Chemistry Polymer and Materials Science Chemistry Polymer and Materials Science A comparative study on the proton magnetic resonance of the dinucleoside monophosphates TpT, dApT, TpdA, the trinucleoside diphosphates dApTpT, TpTpdA, and poly T has been made. The purpose of this investigation was to establish whether in a trimer the proton chemical shifts of one terminal residue are influenced by the magnetic anistropy of the other terminal residue. The conformation of the trimers was first studied and shown to the similar to that of the corresponding dimer, except that of the percentage of the lefthanded conformers in the population of the trimers is probably lower than in the population of the dimers. The methylprotons, H-6, and H-1′ of the 3′-terminal T residue in TpTpdA (or the 5′-terminal T residue in dApTpT) are found to be more upfield than the same protons on the dimer TpT up to a magnitude of about 0.1 ppm. The shielding of these protons of the terminal T(s) in these trimers is even larger than those corresponding protons in the poly(T) at the same condition. From these results, it is concluded that a distant shielding effect is exerted by the 5′-terminal. A residue (or by the 3′-terminal A residue) on the other terminal residue in the trimers studied. 0006-3525 00063525 Wiley-Blackwell |
| shingle_title_1 | The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. |
| shingle_title_2 | The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. |
| shingle_title_3 | The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. |
| shingle_title_4 | The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. |
| sigel_instance_filter | dkfz geomar wilbert ipn albert |
| source_archive | Wiley InterScience Backfile Collection 1832-2000 |
| timestamp | 2024-05-06T10:14:59.424Z |
| titel | The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. |
| titel_suche | The distant shielding effect in trinucleoside diposphatesNo.3 in a series entitled Studies on Oligonucleotides. |
| topic | V |
| uid | nat_lic_papers_NLM159549531 |