Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk
Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S.
American Association for the Advancement of Science (AAAS)
Published 2018
American Association for the Advancement of Science (AAAS)
Published 2018
| Publication Date: |
2018-12-14
|
|---|---|
| Publisher: |
American Association for the Advancement of Science (AAAS)
|
| Print ISSN: |
0036-8075
|
| Electronic ISSN: |
1095-9203
|
| Topics: |
Biology
Chemistry and Pharmacology
Geosciences
Computer Science
Medicine
Natural Sciences in General
Physics
|
| Keywords: |
Genetics, Neuroscience, Online Only
|
| Published by: |
| _version_ | 1836399104706478080 |
|---|---|
| autor | Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. |
| beschreibung | To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization. |
| citation_standardnr | 6369577 |
| datenlieferant | ipn_articles |
| feed_id | 25 |
| feed_publisher | American Association for the Advancement of Science (AAAS) |
| feed_publisher_url | http://www.aaas.org/ |
| insertion_date | 2018-12-14 |
| journaleissn | 1095-9203 |
| journalissn | 0036-8075 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | American Association for the Advancement of Science (AAAS) |
| quelle | Science |
| relation | http://science.sciencemag.org/cgi/content/short/362/6420/eaat4311?rss=1 |
| schlagwort | Genetics, Neuroscience, Online Only |
| search_space | articles |
| shingle_author_1 | Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. |
| shingle_author_2 | Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. |
| shingle_author_3 | Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. |
| shingle_author_4 | Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. |
| shingle_catch_all_1 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk Genetics, Neuroscience, Online Only To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization. Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_2 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk Genetics, Neuroscience, Online Only To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization. Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_3 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk Genetics, Neuroscience, Online Only To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization. Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_4 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk Genetics, Neuroscience, Online Only To explore the developmental reorganization of the three-dimensional genome of the brain in the context of neuropsychiatric disease, we monitored chromosomal conformations in differentiating neural progenitor cells. Neuronal and glial differentiation was associated with widespread developmental remodeling of the chromosomal contact map and included interactions anchored in common variant sequences that confer heritable risk for schizophrenia. We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization. Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., La; Marca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., Mac; Donald, M., Hoffman, G. E., Roussos, P., Zhang, B., Hahn, C.-G., Weng, Z., Brennand, K. J., Akbarian, S. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_title_1 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk |
| shingle_title_2 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk |
| shingle_title_3 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk |
| shingle_title_4 | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk |
| timestamp | 2025-06-30T23:37:40.373Z |
| titel | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk |
| titel_suche | Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk |
| topic | W V TE-TZ SQ-SU WW-YZ TA-TD U |
| uid | ipn_articles_6369577 |