Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]

Publication Date:
2018-12-11
Publisher:
The American Association of Immunologists (AAI)
Print ISSN:
0022-1767
Electronic ISSN:
1550-6606
Topics:
Medicine
Published by:
http://www.aai.org/
_version_ 1836399101323771904
autor Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
beschreibung IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88–IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1–MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections.
citation_standardnr 6367477
datenlieferant ipn_articles
feed_id 333
feed_publisher The American Association of Immunologists (AAI)
feed_publisher_url http://www.aai.org/
insertion_date 2018-12-11
journaleissn 1550-6606
journalissn 0022-1767
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Association of Immunologists (AAI)
quelle Journal of Immunology
relation http://www.jimmunol.org/cgi/content/short/201/12/3641?rss=1
search_space articles
shingle_author_1 Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
shingle_author_2 Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
shingle_author_3 Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
shingle_author_4 Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
shingle_catch_all_1 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88–IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1–MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections.
Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_2 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88–IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1–MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections.
Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_3 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88–IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1–MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections.
Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_4 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
IL-1, generally considered an amplifier of adaptive immune responses, has been proposed for use as adjuvant during immunization with weak immunogens. However, its effects on memory T cell function remain largely undefined. Using the murine model of acute viral infection, in this paper, we show that in addition to augmenting the size of the Ag-specific pool, IL-1 signals act directly on CD8 T cells to promote the quality of effector and memory responses. Ablation of IL-1R1 or MyD88 signaling in T cells led to functional impairment; both the ability to produce multiple cytokines on a per cell basis (polyfunctionality) and the potential for recall proliferation in response to antigenic restimulation were compromised. IL-1 supplementation during priming augmented the expansion of Ag-specific CD8 T cells through the MyD88–IRAK1/4 axis, resulting in a larger memory pool capable of robust secondary expansion in response to rechallange. Together, these findings demonstrate a critical role of the IL-1–MyD88 axis in programming the quantity and quality of memory CD8 T cell responses and support the notion that IL-1 supplementation may be exploited to enhance adoptive T cell therapies against cancers and chronic infections.
Sarkar, S., Yuzefpolskiy, Y., Xiao, H., Baumann, F. M., Yim, S., Lee, D. J., Schenten, D., Kalia, V.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_title_1 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
shingle_title_2 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
shingle_title_3 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
shingle_title_4 Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
timestamp 2025-06-30T23:37:37.528Z
titel Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
titel_suche Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals [INFECTIOUS DISEASE AND HOST RESPONSE]
topic WW-YZ
uid ipn_articles_6367477