Viscous control of cellular respiration by membrane lipid composition
Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D.
American Association for the Advancement of Science (AAAS)
Published 2018
American Association for the Advancement of Science (AAAS)
Published 2018
| Publication Date: |
2018-12-07
|
|---|---|
| Publisher: |
American Association for the Advancement of Science (AAAS)
|
| Print ISSN: |
0036-8075
|
| Electronic ISSN: |
1095-9203
|
| Topics: |
Biology
Chemistry and Pharmacology
Geosciences
Computer Science
Medicine
Natural Sciences in General
Physics
|
| Keywords: |
Biochemistry, Molecular Biology
|
| Published by: |
| _version_ | 1836399099610398721 |
|---|---|
| autor | Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. |
| beschreibung | Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes. |
| citation_standardnr | 6366397 |
| datenlieferant | ipn_articles |
| feed_id | 25 |
| feed_publisher | American Association for the Advancement of Science (AAAS) |
| feed_publisher_url | http://www.aaas.org/ |
| insertion_date | 2018-12-07 |
| journaleissn | 1095-9203 |
| journalissn | 0036-8075 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | American Association for the Advancement of Science (AAAS) |
| quelle | Science |
| relation | http://science.sciencemag.org/cgi/content/short/362/6419/1186?rss=1 |
| schlagwort | Biochemistry, Molecular Biology |
| search_space | articles |
| shingle_author_1 | Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. |
| shingle_author_2 | Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. |
| shingle_author_3 | Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. |
| shingle_author_4 | Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. |
| shingle_catch_all_1 | Viscous control of cellular respiration by membrane lipid composition Biochemistry, Molecular Biology Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes. Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_2 | Viscous control of cellular respiration by membrane lipid composition Biochemistry, Molecular Biology Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes. Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_3 | Viscous control of cellular respiration by membrane lipid composition Biochemistry, Molecular Biology Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes. Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_4 | Viscous control of cellular respiration by membrane lipid composition Biochemistry, Molecular Biology Lipid composition determines the physical properties of biological membranes and can vary substantially between and within organisms. We describe a specific role for the viscosity of energy-transducing membranes in cellular respiration. Engineering of fatty acid biosynthesis in Escherichia coli allowed us to titrate inner membrane viscosity across a 10-fold range by controlling the abundance of unsaturated or branched lipids. These fluidizing lipids tightly controlled respiratory metabolism, an effect that can be explained with a quantitative model of the electron transport chain (ETC) that features diffusion-coupled reactions between enzymes and electron carriers (quinones). Lipid unsaturation also modulated mitochondrial respiration in engineered budding yeast strains. Thus, diffusion in the ETC may serve as an evolutionary constraint for lipid composition in respiratory membranes. Budin, I., de Rond, T., Chen, Y., Chan, L. J. G., Petzold, C. J., Keasling, J. D. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_title_1 | Viscous control of cellular respiration by membrane lipid composition |
| shingle_title_2 | Viscous control of cellular respiration by membrane lipid composition |
| shingle_title_3 | Viscous control of cellular respiration by membrane lipid composition |
| shingle_title_4 | Viscous control of cellular respiration by membrane lipid composition |
| timestamp | 2025-06-30T23:37:35.900Z |
| titel | Viscous control of cellular respiration by membrane lipid composition |
| titel_suche | Viscous control of cellular respiration by membrane lipid composition |
| topic | W V TE-TZ SQ-SU WW-YZ TA-TD U |
| uid | ipn_articles_6366397 |