Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]

Publication Date:
2018-11-13
Publisher:
The Company of Biologists
Print ISSN:
0950-1991
Electronic ISSN:
1477-9129
Topics:
Biology
Keywords:
Plant development
Published by:
http://www.biologists.com/
_version_ 1839208226655043584
autor Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
beschreibung Raksha Ravikumar, Nils Kalbfuss, Delphine Gendre, Alexander Steiner, Melina Altmann, Stefan Altmann, Katarzyna Rybak, Holger Edelmann, Friederike Stephan, Marko Lampe, Eva Facher, Gerhard Wanner, Pascal Falter-Braun, Rishikesh P. Bhalerao, and Farhah F. Assaad The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions.
citation_standardnr 6356151
datenlieferant ipn_articles
feed_id 1748
feed_publisher The Company of Biologists
feed_publisher_url http://www.biologists.com/
insertion_date 2018-11-13
journaleissn 1477-9129
journalissn 0950-1991
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The Company of Biologists
quelle Development
relation http://dev.biologists.org/cgi/content/short/145/21/dev169201?rss=1
schlagwort Plant development
search_space articles
shingle_author_1 Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
shingle_author_2 Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
shingle_author_3 Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
shingle_author_4 Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
shingle_catch_all_1 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
Plant development
Raksha Ravikumar, Nils Kalbfuss, Delphine Gendre, Alexander Steiner, Melina Altmann, Stefan Altmann, Katarzyna Rybak, Holger Edelmann, Friederike Stephan, Marko Lampe, Eva Facher, Gerhard Wanner, Pascal Falter-Braun, Rishikesh P. Bhalerao, and Farhah F. Assaad The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions.
Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
The Company of Biologists
0950-1991
09501991
1477-9129
14779129
shingle_catch_all_2 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
Plant development
Raksha Ravikumar, Nils Kalbfuss, Delphine Gendre, Alexander Steiner, Melina Altmann, Stefan Altmann, Katarzyna Rybak, Holger Edelmann, Friederike Stephan, Marko Lampe, Eva Facher, Gerhard Wanner, Pascal Falter-Braun, Rishikesh P. Bhalerao, and Farhah F. Assaad The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions.
Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
The Company of Biologists
0950-1991
09501991
1477-9129
14779129
shingle_catch_all_3 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
Plant development
Raksha Ravikumar, Nils Kalbfuss, Delphine Gendre, Alexander Steiner, Melina Altmann, Stefan Altmann, Katarzyna Rybak, Holger Edelmann, Friederike Stephan, Marko Lampe, Eva Facher, Gerhard Wanner, Pascal Falter-Braun, Rishikesh P. Bhalerao, and Farhah F. Assaad The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions.
Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
The Company of Biologists
0950-1991
09501991
1477-9129
14779129
shingle_catch_all_4 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
Plant development
Raksha Ravikumar, Nils Kalbfuss, Delphine Gendre, Alexander Steiner, Melina Altmann, Stefan Altmann, Katarzyna Rybak, Holger Edelmann, Friederike Stephan, Marko Lampe, Eva Facher, Gerhard Wanner, Pascal Falter-Braun, Rishikesh P. Bhalerao, and Farhah F. Assaad The trans-Golgi-network (TGN) has essential housekeeping functions in secretion, endocytosis and protein sorting, but also more specialized functions in plant development. How the robustness of basal TGN function is ensured while specialized functions are differentially regulated is poorly understood. Here, we investigate two key regulators of TGN structure and function, ECHIDNA and the Transport Protein Particle II (TRAPPII) tethering complex. An analysis of physical, network and genetic interactions suggests that two network communities are implicated in TGN function and that ECHIDNA and TRAPPII belong to distinct yet overlapping pathways. Whereas ECHIDNA and TRAPPII colocalized at the TGN in interphase cells, their localization diverged in dividing cells. Moreover, ECHIDNA and TRAPPII localization patterns were mutually independent. TGN structure, endocytosis and sorting decisions were differentially impacted in echidna and trappii mutants. Our analyses point to a partitioning of specialized TGN functions, with ECHIDNA being required for cell elongation and TRAPPII for cytokinesis. Two independent pathways able to compensate for each other might contribute to the robustness of TGN housekeeping functions and to the responsiveness and fine tuning of its specialized functions.
Ravikumar, R., Kalbfuss, N., Gendre, D., Steiner, A., Altmann, M., Altmann, S., Rybak, K., Edelmann, H., Stephan, F., Lampe, M., Facher, E., Wanner, G., Falter-Braun, P., Bhalerao, R. P., Assaad, F. F.
The Company of Biologists
0950-1991
09501991
1477-9129
14779129
shingle_title_1 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
shingle_title_2 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
shingle_title_3 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
shingle_title_4 Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
timestamp 2025-07-31T23:47:27.884Z
titel Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
titel_suche Independent yet overlapping pathways ensure the robustness and responsiveness of trans-Golgi network functions in Arabidopsis [RESEARCH ARTICLE]
topic W
uid ipn_articles_6356151