Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma

Publication Date:
2018-11-09
Publisher:
American Society of Hematology (ASH)
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
Medicine
Keywords:
Immunobiology and Immunotherapy, Lymphoid Neoplasia
Published by:
http://www.hematology.org/
_version_ 1839208224428916736
autor Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
beschreibung To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 x 10 –10 ), 6q23.3 (rs1002658; P = 2.97 x 10 –8 ), 11q23.1 (rs7111520; P = 1.44 x 10 –11 ), 16p11.2 (rs6565176; P = 4.00 x 10 –8 ), and 20q13.12 (rs2425752; P = 2.01 x 10 –8 ). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-B activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
citation_standardnr 6354989
datenlieferant ipn_articles
feed_id 310
feed_publisher American Society of Hematology (ASH)
feed_publisher_url http://www.hematology.org/
insertion_date 2018-11-09
journaleissn 1528-0020
journalissn 0006-4971
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Society of Hematology (ASH)
quelle Blood
relation http://www.bloodjournal.org/cgi/content/short/132/19/2040?rss=1
schlagwort Immunobiology and Immunotherapy, Lymphoid Neoplasia
search_space articles
shingle_author_1 Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
shingle_author_2 Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
shingle_author_3 Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
shingle_author_4 Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
shingle_catch_all_1 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
Immunobiology and Immunotherapy, Lymphoid Neoplasia
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 x 10 –10 ), 6q23.3 (rs1002658; P = 2.97 x 10 –8 ), 11q23.1 (rs7111520; P = 1.44 x 10 –11 ), 16p11.2 (rs6565176; P = 4.00 x 10 –8 ), and 20q13.12 (rs2425752; P = 2.01 x 10 –8 ). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-B activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_catch_all_2 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
Immunobiology and Immunotherapy, Lymphoid Neoplasia
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 x 10 –10 ), 6q23.3 (rs1002658; P = 2.97 x 10 –8 ), 11q23.1 (rs7111520; P = 1.44 x 10 –11 ), 16p11.2 (rs6565176; P = 4.00 x 10 –8 ), and 20q13.12 (rs2425752; P = 2.01 x 10 –8 ). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-B activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_catch_all_3 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
Immunobiology and Immunotherapy, Lymphoid Neoplasia
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 x 10 –10 ), 6q23.3 (rs1002658; P = 2.97 x 10 –8 ), 11q23.1 (rs7111520; P = 1.44 x 10 –11 ), 16p11.2 (rs6565176; P = 4.00 x 10 –8 ), and 20q13.12 (rs2425752; P = 2.01 x 10 –8 ). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-B activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_catch_all_4 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
Immunobiology and Immunotherapy, Lymphoid Neoplasia
To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 x 10 –10 ), 6q23.3 (rs1002658; P = 2.97 x 10 –8 ), 11q23.1 (rs7111520; P = 1.44 x 10 –11 ), 16p11.2 (rs6565176; P = 4.00 x 10 –8 ), and 20q13.12 (rs2425752; P = 2.01 x 10 –8 ). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-B activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL.
Sud, A., Thomsen, H., Orlando, G., Försti, A., Law, P. J., Broderick, P., Cooke, R., Hariri, F., Pastinen, T., Easton, D. F., Pharoah, P. D. P., Dunning, A. M., Peto, J., Canzian, F., Eeles, R., Kote-Jarai, Z., Muir, K., Pashayan, N., Campa, D., the PRACTICAL Consortium, Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., von Strandmann, E. P., Swerdlow, A. J., Engert, A., Orr, N., Hemminki, K., Houlston, R. S.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_title_1 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
shingle_title_2 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
shingle_title_3 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
shingle_title_4 Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
timestamp 2025-07-31T23:47:25.782Z
titel Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
titel_suche Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma
topic W
WW-YZ
uid ipn_articles_6354989