Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression

Publication Date:
2018-10-17
Publisher:
Nature Publishing Group (NPG)
Electronic ISSN:
2041-1723
Topics:
Biology
Chemistry and Pharmacology
Natural Sciences in General
Physics
Published by:
http://www.nature.com/
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autor Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
beschreibung Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression Human breast tumor-infiltrating CD8〈sup〉+〈/sup〉 T cells retain polyfunctionality despite PD-1 expression, Published online: 16 October 2018; doi:10.1038/s41467-018-06653-9 Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.
citation_standardnr 6345341
datenlieferant ipn_articles
feed_id 134647
feed_publisher Nature Publishing Group (NPG)
feed_publisher_url http://www.nature.com/
insertion_date 2018-10-17
journaleissn 2041-1723
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Nature Publishing Group (NPG)
quelle Nature Communications
relation http://feeds.nature.com/~r/ncomms/rss/current/~3/3bJ9LfCP6Do/s41467-018-06653-9
search_space articles
shingle_author_1 Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
shingle_author_2 Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
shingle_author_3 Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
shingle_author_4 Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
shingle_catch_all_1 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression Human breast tumor-infiltrating CD8<sup>+</sup> T cells retain polyfunctionality despite PD-1 expression, Published online: 16 October 2018; doi:10.1038/s41467-018-06653-9 Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.
Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_2 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression Human breast tumor-infiltrating CD8<sup>+</sup> T cells retain polyfunctionality despite PD-1 expression, Published online: 16 October 2018; doi:10.1038/s41467-018-06653-9 Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.
Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_3 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression Human breast tumor-infiltrating CD8<sup>+</sup> T cells retain polyfunctionality despite PD-1 expression, Published online: 16 October 2018; doi:10.1038/s41467-018-06653-9 Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.
Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_4 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression Human breast tumor-infiltrating CD8<sup>+</sup> T cells retain polyfunctionality despite PD-1 expression, Published online: 16 October 2018; doi:10.1038/s41467-018-06653-9 Expression of the checkpoint molecule programmed cell death protein 1 (PD-1) is considered a marker of T cells exhaustion. Here the authors show that CD8T cells isolated from breast cancer patients are perfectly functional despite PD-1 expression while those isolated from melanoma patients are not.
Colt A. Egelston; Christian Avalos; Travis Y. Tu; Diana L. Simons; Grecia Jimenez; Jae Y. Jung; Laleh Melstrom; Kim Margolin; John H. Yim; Laura Kruper; Joanne Mortimer; Peter P. Lee
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_title_1 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
shingle_title_2 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
shingle_title_3 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
shingle_title_4 Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
timestamp 2025-06-30T23:37:06.792Z
titel Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
titel_suche Human breast tumor-infiltrating CD8 + T cells retain polyfunctionality despite PD-1 expression
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uid ipn_articles_6345341