The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]

Publication Date:
2018-10-02
Publisher:
Cold Spring Harbor Laboratory Press
Print ISSN:
0890-9369
Topics:
Biology
Published by:
http://www.cshlpress.com/
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autor Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
beschreibung MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.
citation_standardnr 6339451
datenlieferant ipn_articles
feed_id 1644
feed_publisher Cold Spring Harbor Laboratory Press
feed_publisher_url http://www.cshlpress.com/
insertion_date 2018-10-02
journalissn 0890-9369
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Cold Spring Harbor Laboratory Press
quelle Genes & Development
relation http://genesdev.cshlp.org/cgi/content/short/32/19-20/1303?rss=1
search_space articles
shingle_author_1 Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
shingle_author_2 Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
shingle_author_3 Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
shingle_author_4 Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
shingle_catch_all_1 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.
Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_catch_all_2 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.
Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_catch_all_3 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.
Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_catch_all_4 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.
Lafita-Navarro, M. C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R., Brabletz, T., Scaglioni, P. P., Shay, J. W., Conacci-Sorrell, M.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_title_1 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
shingle_title_2 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
shingle_title_3 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
shingle_title_4 The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
timestamp 2025-06-30T23:36:58.692Z
titel The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
titel_suche The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells [Research Communications]
topic W
uid ipn_articles_6339451