Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases

Publication Date:
2018-10-02
Publisher:
The American Association for Cancer Research (AACR)
Print ISSN:
1078-0432
Electronic ISSN:
1557-3265
Topics:
Medicine
Published by:
_version_ 1836399060763803648
autor Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
beschreibung Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and morphology in vivo . Experimental Design: Untreated preclinical tumors with different levels of vascularization were imaged sequentially using DCE-MRI and CT. Relationships between functional parameters from MR ( i AUC, K trans , and BAT frac ) and structural parameters from CT (vessel volume, radius, and tortuosity) were assessed using linear models. Tumors treated with anti-VEGFR2 antibody were then imaged to determine whether antiangiogenic therapy altered these relationships. Finally, functional–structural relationships were measured in 10 patients with liver metastases from colorectal cancer. Results: Functional parameters i AUC and K trans primarily reflected vessel volume in untreated preclinical tumors. The relationships varied spatially and with tumor vascularity, and were altered by antiangiogenic treatment. In human liver metastases, all three structural parameters were linearly correlated with i AUC and K trans . For i AUC, structural parameters also modified each other's effect. Conclusions: Our findings suggest that MR imaging biomarkers of vascular function are linked to structural changes in tumor vessels and that antiangiogenic therapy can affect this link. Our work also demonstrates the feasibility of three-dimensional functional–structural validation of MR biomarkers in vivo to improve their biological interpretation and clinical utility. Clin Cancer Res; 24(19); 4694–704. ©2018 AACR .
citation_standardnr 6339400
datenlieferant ipn_articles
feed_id 9363
feed_publisher The American Association for Cancer Research (AACR)
feed_publisher_url http://www.aacr.org/
insertion_date 2018-10-02
journaleissn 1557-3265
journalissn 1078-0432
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Association for Cancer Research (AACR)
quelle Clinical Cancer Research
relation http://clincancerres.aacrjournals.org/cgi/content/short/24/19/4694?rss=1
search_space articles
shingle_author_1 Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
shingle_author_2 Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
shingle_author_3 Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
shingle_author_4 Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
shingle_catch_all_1 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and morphology in vivo . Experimental Design: Untreated preclinical tumors with different levels of vascularization were imaged sequentially using DCE-MRI and CT. Relationships between functional parameters from MR ( i AUC, K trans , and BAT frac ) and structural parameters from CT (vessel volume, radius, and tortuosity) were assessed using linear models. Tumors treated with anti-VEGFR2 antibody were then imaged to determine whether antiangiogenic therapy altered these relationships. Finally, functional–structural relationships were measured in 10 patients with liver metastases from colorectal cancer. Results: Functional parameters i AUC and K trans primarily reflected vessel volume in untreated preclinical tumors. The relationships varied spatially and with tumor vascularity, and were altered by antiangiogenic treatment. In human liver metastases, all three structural parameters were linearly correlated with i AUC and K trans . For i AUC, structural parameters also modified each other's effect. Conclusions: Our findings suggest that MR imaging biomarkers of vascular function are linked to structural changes in tumor vessels and that antiangiogenic therapy can affect this link. Our work also demonstrates the feasibility of three-dimensional functional–structural validation of MR biomarkers in vivo to improve their biological interpretation and clinical utility. Clin Cancer Res; 24(19); 4694–704. ©2018 AACR .
Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
The American Association for Cancer Research (AACR)
1078-0432
10780432
1557-3265
15573265
shingle_catch_all_2 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and morphology in vivo . Experimental Design: Untreated preclinical tumors with different levels of vascularization were imaged sequentially using DCE-MRI and CT. Relationships between functional parameters from MR ( i AUC, K trans , and BAT frac ) and structural parameters from CT (vessel volume, radius, and tortuosity) were assessed using linear models. Tumors treated with anti-VEGFR2 antibody were then imaged to determine whether antiangiogenic therapy altered these relationships. Finally, functional–structural relationships were measured in 10 patients with liver metastases from colorectal cancer. Results: Functional parameters i AUC and K trans primarily reflected vessel volume in untreated preclinical tumors. The relationships varied spatially and with tumor vascularity, and were altered by antiangiogenic treatment. In human liver metastases, all three structural parameters were linearly correlated with i AUC and K trans . For i AUC, structural parameters also modified each other's effect. Conclusions: Our findings suggest that MR imaging biomarkers of vascular function are linked to structural changes in tumor vessels and that antiangiogenic therapy can affect this link. Our work also demonstrates the feasibility of three-dimensional functional–structural validation of MR biomarkers in vivo to improve their biological interpretation and clinical utility. Clin Cancer Res; 24(19); 4694–704. ©2018 AACR .
Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
The American Association for Cancer Research (AACR)
1078-0432
10780432
1557-3265
15573265
shingle_catch_all_3 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and morphology in vivo . Experimental Design: Untreated preclinical tumors with different levels of vascularization were imaged sequentially using DCE-MRI and CT. Relationships between functional parameters from MR ( i AUC, K trans , and BAT frac ) and structural parameters from CT (vessel volume, radius, and tortuosity) were assessed using linear models. Tumors treated with anti-VEGFR2 antibody were then imaged to determine whether antiangiogenic therapy altered these relationships. Finally, functional–structural relationships were measured in 10 patients with liver metastases from colorectal cancer. Results: Functional parameters i AUC and K trans primarily reflected vessel volume in untreated preclinical tumors. The relationships varied spatially and with tumor vascularity, and were altered by antiangiogenic treatment. In human liver metastases, all three structural parameters were linearly correlated with i AUC and K trans . For i AUC, structural parameters also modified each other's effect. Conclusions: Our findings suggest that MR imaging biomarkers of vascular function are linked to structural changes in tumor vessels and that antiangiogenic therapy can affect this link. Our work also demonstrates the feasibility of three-dimensional functional–structural validation of MR biomarkers in vivo to improve their biological interpretation and clinical utility. Clin Cancer Res; 24(19); 4694–704. ©2018 AACR .
Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
The American Association for Cancer Research (AACR)
1078-0432
10780432
1557-3265
15573265
shingle_catch_all_4 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
Purpose: Tumor vessels influence the growth and response of tumors to therapy. Imaging vascular changes in vivo using dynamic contrast-enhanced MRI (DCE-MRI) has shown potential to guide clinical decision making for treatment. However, quantitative MR imaging biomarkers of vascular function have not been widely adopted, partly because their relationship to structural changes in vessels remains unclear. We aimed to elucidate the relationships between vessel function and morphology in vivo . Experimental Design: Untreated preclinical tumors with different levels of vascularization were imaged sequentially using DCE-MRI and CT. Relationships between functional parameters from MR ( i AUC, K trans , and BAT frac ) and structural parameters from CT (vessel volume, radius, and tortuosity) were assessed using linear models. Tumors treated with anti-VEGFR2 antibody were then imaged to determine whether antiangiogenic therapy altered these relationships. Finally, functional–structural relationships were measured in 10 patients with liver metastases from colorectal cancer. Results: Functional parameters i AUC and K trans primarily reflected vessel volume in untreated preclinical tumors. The relationships varied spatially and with tumor vascularity, and were altered by antiangiogenic treatment. In human liver metastases, all three structural parameters were linearly correlated with i AUC and K trans . For i AUC, structural parameters also modified each other's effect. Conclusions: Our findings suggest that MR imaging biomarkers of vascular function are linked to structural changes in tumor vessels and that antiangiogenic therapy can affect this link. Our work also demonstrates the feasibility of three-dimensional functional–structural validation of MR biomarkers in vivo to improve their biological interpretation and clinical utility. Clin Cancer Res; 24(19); 4694–704. ©2018 AACR .
Kannan, P., Kretzschmar, W. W., Winter, H., Warren, D., Bates, R., Allen, P. D., Syed, N., Irving, B., Papiez, B. W., Kaeppler, J., Markelc, B., Kinchesh, P., Gilchrist, S., Smart, S., Schnabel, J. A., Maughan, T., Harris, A. L., Muschel, R. J., Partridge, M., Sharma, R. A., Kersemans, V.
The American Association for Cancer Research (AACR)
1078-0432
10780432
1557-3265
15573265
shingle_title_1 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
shingle_title_2 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
shingle_title_3 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
shingle_title_4 Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
timestamp 2025-06-30T23:36:58.692Z
titel Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
titel_suche Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases
topic WW-YZ
uid ipn_articles_6339400