Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis

Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
American Association for the Advancement of Science (AAAS)
Published 2018
Publication Date:
2018-09-20
Publisher:
American Association for the Advancement of Science (AAAS)
Electronic ISSN:
2375-2548
Topics:
Natural Sciences in General
Published by:
http://www.aaas.org/
_version_ 1836399054086471680
autor Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
beschreibung Supramolecular nanoassemblies that respond to multiple stimuli exhibit high therapeutic efficacy against malignant tumors. We report a new type of supramolecular nanofiber that integrates targeting peptide–coated magnetic nanoparticles with β-cyclodextrin–bearing polysaccharides in a complex held together by multivalent interactions. The nanofibers not only exhibited reversible photo-triggered association and disassociation depending on irradiation wavelength but also underwent magnetic field–controlled directional aggregation, even in the rather weak geomagnetic field. The nanofibers markedly suppressed invasion by and metastasis of cancer cells both in vitro and in vivo. Furthermore, compared with control mice, tumor-burdened mice treated with the nanofibers showed a lower rate of mortality from the metastatic spread of tumor cells. Our results suggest that these geomagnetism- and photo-controlled nanofibers may facilitate the rapid development of efficacious anticancer therapies.
citation_standardnr 6335026
datenlieferant ipn_articles
feed_id 228416
feed_publisher American Association for the Advancement of Science (AAAS)
feed_publisher_url http://www.aaas.org/
insertion_date 2018-09-20
journaleissn 2375-2548
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Association for the Advancement of Science (AAAS)
quelle Science Advances
relation http://advances.sciencemag.org/cgi/content/short/4/9/eaat2297?rss=1
search_space articles
shingle_author_1 Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
shingle_author_2 Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
shingle_author_3 Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
shingle_author_4 Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
shingle_catch_all_1 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
Supramolecular nanoassemblies that respond to multiple stimuli exhibit high therapeutic efficacy against malignant tumors. We report a new type of supramolecular nanofiber that integrates targeting peptide–coated magnetic nanoparticles with β-cyclodextrin–bearing polysaccharides in a complex held together by multivalent interactions. The nanofibers not only exhibited reversible photo-triggered association and disassociation depending on irradiation wavelength but also underwent magnetic field–controlled directional aggregation, even in the rather weak geomagnetic field. The nanofibers markedly suppressed invasion by and metastasis of cancer cells both in vitro and in vivo. Furthermore, compared with control mice, tumor-burdened mice treated with the nanofibers showed a lower rate of mortality from the metastatic spread of tumor cells. Our results suggest that these geomagnetism- and photo-controlled nanofibers may facilitate the rapid development of efficacious anticancer therapies.
Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_2 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
Supramolecular nanoassemblies that respond to multiple stimuli exhibit high therapeutic efficacy against malignant tumors. We report a new type of supramolecular nanofiber that integrates targeting peptide–coated magnetic nanoparticles with β-cyclodextrin–bearing polysaccharides in a complex held together by multivalent interactions. The nanofibers not only exhibited reversible photo-triggered association and disassociation depending on irradiation wavelength but also underwent magnetic field–controlled directional aggregation, even in the rather weak geomagnetic field. The nanofibers markedly suppressed invasion by and metastasis of cancer cells both in vitro and in vivo. Furthermore, compared with control mice, tumor-burdened mice treated with the nanofibers showed a lower rate of mortality from the metastatic spread of tumor cells. Our results suggest that these geomagnetism- and photo-controlled nanofibers may facilitate the rapid development of efficacious anticancer therapies.
Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_3 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
Supramolecular nanoassemblies that respond to multiple stimuli exhibit high therapeutic efficacy against malignant tumors. We report a new type of supramolecular nanofiber that integrates targeting peptide–coated magnetic nanoparticles with β-cyclodextrin–bearing polysaccharides in a complex held together by multivalent interactions. The nanofibers not only exhibited reversible photo-triggered association and disassociation depending on irradiation wavelength but also underwent magnetic field–controlled directional aggregation, even in the rather weak geomagnetic field. The nanofibers markedly suppressed invasion by and metastasis of cancer cells both in vitro and in vivo. Furthermore, compared with control mice, tumor-burdened mice treated with the nanofibers showed a lower rate of mortality from the metastatic spread of tumor cells. Our results suggest that these geomagnetism- and photo-controlled nanofibers may facilitate the rapid development of efficacious anticancer therapies.
Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_4 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
Supramolecular nanoassemblies that respond to multiple stimuli exhibit high therapeutic efficacy against malignant tumors. We report a new type of supramolecular nanofiber that integrates targeting peptide–coated magnetic nanoparticles with β-cyclodextrin–bearing polysaccharides in a complex held together by multivalent interactions. The nanofibers not only exhibited reversible photo-triggered association and disassociation depending on irradiation wavelength but also underwent magnetic field–controlled directional aggregation, even in the rather weak geomagnetic field. The nanofibers markedly suppressed invasion by and metastasis of cancer cells both in vitro and in vivo. Furthermore, compared with control mice, tumor-burdened mice treated with the nanofibers showed a lower rate of mortality from the metastatic spread of tumor cells. Our results suggest that these geomagnetism- and photo-controlled nanofibers may facilitate the rapid development of efficacious anticancer therapies.
Yu, Q., Zhang, Y.-M., Liu, Y.-H., Xu, X., Liu, Y.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_title_1 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
shingle_title_2 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
shingle_title_3 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
shingle_title_4 Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
timestamp 2025-06-30T23:36:52.160Z
titel Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
titel_suche Magnetism and photo dual-controlled supramolecular assembly for suppression of tumor invasion and metastasis
topic TA-TD
uid ipn_articles_6335026