The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE]
| Publication Date: |
2018-09-16
|
|---|---|
| Publisher: |
The Company of Biologists
|
| Print ISSN: |
0950-1991
|
| Electronic ISSN: |
1477-9129
|
| Topics: |
Biology
|
| Keywords: |
Neural development
|
| Published by: |
| _version_ | 1836399051261607936 |
|---|---|
| autor | Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. |
| beschreibung | Nobuhiro Kurabayashi, Aiki Tanaka, Minh Dang Nguyen, and Kamon Sanada Newborn neurons in the developing neocortex undergo radial migration, a process that is coupled with their precise passage from multipolar to bipolar shape. The cell-extrinsic signals that govern this transition are, however, poorly understood. Here, we find that lysophosphatidic acid (LPA) signaling contributes to the establishment of a bipolar shape in mouse migratory neurons through LPA receptor 4 (LPA4). LPA4 is robustly expressed in migratory neurons. LPA4-depleted neurons show impaired multipolar-to-bipolar transition and become arrested in their migration. Further, LPA4-mediated LPA signaling promotes formation of the pia-directed process in primary neurons overlaid on neocortical slices. In addition, LPA4 depletion is coupled with altered actin organization as well as with destabilization of the F-actin-binding protein filamin A (FlnA). Finally, overexpression of FlnA rescues the morphology and migration defects of LPA4-depleted neurons. Thus, the LPA-LPA4 axis regulates bipolar morphogenesis and radial migration of newborn cortical neurons via remodeling of the actin cytoskeleton. |
| citation_standardnr | 6333107 |
| datenlieferant | ipn_articles |
| feed_id | 1748 |
| feed_publisher | The Company of Biologists |
| feed_publisher_url | http://www.biologists.com/ |
| insertion_date | 2018-09-16 |
| journaleissn | 1477-9129 |
| journalissn | 0950-1991 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The Company of Biologists |
| quelle | Development |
| relation | http://dev.biologists.org/cgi/content/short/145/17/dev162529?rss=1 |
| schlagwort | Neural development |
| search_space | articles |
| shingle_author_1 | Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. |
| shingle_author_2 | Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. |
| shingle_author_3 | Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. |
| shingle_author_4 | Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. |
| shingle_catch_all_1 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] Neural development Nobuhiro Kurabayashi, Aiki Tanaka, Minh Dang Nguyen, and Kamon Sanada Newborn neurons in the developing neocortex undergo radial migration, a process that is coupled with their precise passage from multipolar to bipolar shape. The cell-extrinsic signals that govern this transition are, however, poorly understood. Here, we find that lysophosphatidic acid (LPA) signaling contributes to the establishment of a bipolar shape in mouse migratory neurons through LPA receptor 4 (LPA4). LPA4 is robustly expressed in migratory neurons. LPA4-depleted neurons show impaired multipolar-to-bipolar transition and become arrested in their migration. Further, LPA4-mediated LPA signaling promotes formation of the pia-directed process in primary neurons overlaid on neocortical slices. In addition, LPA4 depletion is coupled with altered actin organization as well as with destabilization of the F-actin-binding protein filamin A (FlnA). Finally, overexpression of FlnA rescues the morphology and migration defects of LPA4-depleted neurons. Thus, the LPA-LPA4 axis regulates bipolar morphogenesis and radial migration of newborn cortical neurons via remodeling of the actin cytoskeleton. Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. The Company of Biologists 0950-1991 09501991 1477-9129 14779129 |
| shingle_catch_all_2 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] Neural development Nobuhiro Kurabayashi, Aiki Tanaka, Minh Dang Nguyen, and Kamon Sanada Newborn neurons in the developing neocortex undergo radial migration, a process that is coupled with their precise passage from multipolar to bipolar shape. The cell-extrinsic signals that govern this transition are, however, poorly understood. Here, we find that lysophosphatidic acid (LPA) signaling contributes to the establishment of a bipolar shape in mouse migratory neurons through LPA receptor 4 (LPA4). LPA4 is robustly expressed in migratory neurons. LPA4-depleted neurons show impaired multipolar-to-bipolar transition and become arrested in their migration. Further, LPA4-mediated LPA signaling promotes formation of the pia-directed process in primary neurons overlaid on neocortical slices. In addition, LPA4 depletion is coupled with altered actin organization as well as with destabilization of the F-actin-binding protein filamin A (FlnA). Finally, overexpression of FlnA rescues the morphology and migration defects of LPA4-depleted neurons. Thus, the LPA-LPA4 axis regulates bipolar morphogenesis and radial migration of newborn cortical neurons via remodeling of the actin cytoskeleton. Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. The Company of Biologists 0950-1991 09501991 1477-9129 14779129 |
| shingle_catch_all_3 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] Neural development Nobuhiro Kurabayashi, Aiki Tanaka, Minh Dang Nguyen, and Kamon Sanada Newborn neurons in the developing neocortex undergo radial migration, a process that is coupled with their precise passage from multipolar to bipolar shape. The cell-extrinsic signals that govern this transition are, however, poorly understood. Here, we find that lysophosphatidic acid (LPA) signaling contributes to the establishment of a bipolar shape in mouse migratory neurons through LPA receptor 4 (LPA4). LPA4 is robustly expressed in migratory neurons. LPA4-depleted neurons show impaired multipolar-to-bipolar transition and become arrested in their migration. Further, LPA4-mediated LPA signaling promotes formation of the pia-directed process in primary neurons overlaid on neocortical slices. In addition, LPA4 depletion is coupled with altered actin organization as well as with destabilization of the F-actin-binding protein filamin A (FlnA). Finally, overexpression of FlnA rescues the morphology and migration defects of LPA4-depleted neurons. Thus, the LPA-LPA4 axis regulates bipolar morphogenesis and radial migration of newborn cortical neurons via remodeling of the actin cytoskeleton. Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. The Company of Biologists 0950-1991 09501991 1477-9129 14779129 |
| shingle_catch_all_4 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] Neural development Nobuhiro Kurabayashi, Aiki Tanaka, Minh Dang Nguyen, and Kamon Sanada Newborn neurons in the developing neocortex undergo radial migration, a process that is coupled with their precise passage from multipolar to bipolar shape. The cell-extrinsic signals that govern this transition are, however, poorly understood. Here, we find that lysophosphatidic acid (LPA) signaling contributes to the establishment of a bipolar shape in mouse migratory neurons through LPA receptor 4 (LPA4). LPA4 is robustly expressed in migratory neurons. LPA4-depleted neurons show impaired multipolar-to-bipolar transition and become arrested in their migration. Further, LPA4-mediated LPA signaling promotes formation of the pia-directed process in primary neurons overlaid on neocortical slices. In addition, LPA4 depletion is coupled with altered actin organization as well as with destabilization of the F-actin-binding protein filamin A (FlnA). Finally, overexpression of FlnA rescues the morphology and migration defects of LPA4-depleted neurons. Thus, the LPA-LPA4 axis regulates bipolar morphogenesis and radial migration of newborn cortical neurons via remodeling of the actin cytoskeleton. Kurabayashi, N., Tanaka, A., Nguyen, M. D., Sanada, K. The Company of Biologists 0950-1991 09501991 1477-9129 14779129 |
| shingle_title_1 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] |
| shingle_title_2 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] |
| shingle_title_3 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] |
| shingle_title_4 | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] |
| timestamp | 2025-06-30T23:36:49.411Z |
| titel | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] |
| titel_suche | The LPA-LPA4 axis is required for establishment of bipolar morphology and radial migration of newborn cortical neurons [RESEARCH ARTICLE] |
| topic | W |
| uid | ipn_articles_6333107 |