Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]

Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
National Academy of Sciences
Published 2018

Publication Date:	2018-09-12
Publisher:	National Academy of Sciences
Print ISSN:	0027-8424
Electronic ISSN:	1091-6490
Topics:	Biology Medicine Natural Sciences in General
Published by:	http://www.nasonline.org/

Staff View

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autor	Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
beschreibung	Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report the crystal structure of an antibody employing both modes of interaction simultaneously and binding two antigen molecules. This human antibody from an...
citation_standardnr	6331325
datenlieferant	ipn_articles
feed_id	113
feed_publisher	National Academy of Sciences
feed_publisher_url	http://www.nasonline.org/
insertion_date	2018-09-12
journaleissn	1091-6490
journalissn	0027-8424
publikationsjahr_anzeige	2018
publikationsjahr_facette	2018
publikationsjahr_intervall	7984:2015-2019
publikationsjahr_sort	2018
publisher	National Academy of Sciences
quelle	PNAS - Proceedings of the National Academy of Sciences
relation	http://www.pnas.org/content/115/37/E8707.short?rss=1
search_space	articles
shingle_author_1	Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
shingle_author_2	Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
shingle_author_3	Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
shingle_author_4	Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton
shingle_catch_all_1	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation] Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report the crystal structure of an antibody employing both modes of interaction simultaneously and binding two antigen molecules. This human antibody from an... Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton National Academy of Sciences 0027-8424 00278424 1091-6490 10916490
shingle_catch_all_2	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation] Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report the crystal structure of an antibody employing both modes of interaction simultaneously and binding two antigen molecules. This human antibody from an... Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton National Academy of Sciences 0027-8424 00278424 1091-6490 10916490
shingle_catch_all_3	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation] Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report the crystal structure of an antibody employing both modes of interaction simultaneously and binding two antigen molecules. This human antibody from an... Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton National Academy of Sciences 0027-8424 00278424 1091-6490 10916490
shingle_catch_all_4	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation] Antibodies classically bind antigens via their complementarity-determining regions, but an alternative mode of interaction involving V-domain framework regions has been observed for some B cell “superantigens.” We report the crystal structure of an antibody employing both modes of interaction simultaneously and binding two antigen molecules. This human antibody from an... Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, Brian J. Sutton National Academy of Sciences 0027-8424 00278424 1091-6490 10916490
shingle_title_1	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]
shingle_title_2	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]
shingle_title_3	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]
shingle_title_4	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]
timestamp	2025-06-30T23:36:46.088Z
titel	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]
titel_suche	Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition [Immunology and Inflammation]
topic	W WW-YZ TA-TD
uid	ipn_articles_6331325