B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation
Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J.
Rockefeller University Press
Published 2018
Rockefeller University Press
Published 2018
| Publication Date: |
2018-09-04
|
|---|---|
| Publisher: |
Rockefeller University Press
|
| Print ISSN: |
0022-1007
|
| Electronic ISSN: |
1540-9538
|
| Topics: |
Medicine
|
| Keywords: |
Infectious Disease and Host Defense
|
| Published by: |
| _version_ | 1836399042446229504 |
|---|---|
| autor | Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. |
| beschreibung | CD8 + T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8 + T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8 + T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes . Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8 + T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development. |
| citation_standardnr | 6327537 |
| datenlieferant | ipn_articles |
| feed_id | 96 |
| feed_publisher | Rockefeller University Press |
| feed_publisher_url | http://www.rupress.org/ |
| insertion_date | 2018-09-04 |
| journaleissn | 1540-9538 |
| journalissn | 0022-1007 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | Rockefeller University Press |
| quelle | Journal of Experimental Medicine |
| relation | http://jem.rupress.org/cgi/content/short/215/9/2429?rss=1 |
| schlagwort | Infectious Disease and Host Defense |
| search_space | articles |
| shingle_author_1 | Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. |
| shingle_author_2 | Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. |
| shingle_author_3 | Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. |
| shingle_author_4 | Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. |
| shingle_catch_all_1 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation Infectious Disease and Host Defense CD8 + T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8 + T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8 + T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes . Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8 + T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development. Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_2 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation Infectious Disease and Host Defense CD8 + T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8 + T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8 + T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes . Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8 + T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development. Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_3 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation Infectious Disease and Host Defense CD8 + T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8 + T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8 + T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes . Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8 + T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development. Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_catch_all_4 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation Infectious Disease and Host Defense CD8 + T cells respond to signals via the T cell receptor (TCR), costimulatory molecules, and immunoregulatory cytokines by developing into diverse populations of effector and memory cells. The relative strength of phosphoinositide 3-kinase (PI3K) signaling early in the T cell response can dramatically influence downstream effector and memory T cell differentiation. We show that initial PI3K signaling during T cell activation results in up-regulation of the signaling scaffold B cell adaptor for PI3K (BCAP), which further potentiates PI3K signaling and promotes the accumulation of CD8 + T cells with a terminally differentiated effector phenotype. Accordingly, BCAP-deficient CD8 + T cells have attenuated clonal expansion and altered effector and memory T cell development following infection with Listeria monocytogenes . Thus, induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8 + T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development. Singh, M. D., Ni, M., Sullivan, J. M., Hamerman, J. A., Campbell, D. J. Rockefeller University Press 0022-1007 00221007 1540-9538 15409538 |
| shingle_title_1 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation |
| shingle_title_2 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation |
| shingle_title_3 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation |
| shingle_title_4 | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation |
| timestamp | 2025-06-30T23:36:41.168Z |
| titel | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation |
| titel_suche | B cell adaptor for PI3-kinase (BCAP) modulates CD8+ effector and memory T cell differentiation |
| topic | WW-YZ |
| uid | ipn_articles_6327537 |