A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY]
Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L.
The American Association of Immunologists (AAI)
Published 2018
The American Association of Immunologists (AAI)
Published 2018
| Publication Date: |
2018-08-21
|
|---|---|
| Publisher: |
The American Association of Immunologists (AAI)
|
| Print ISSN: |
0022-1767
|
| Electronic ISSN: |
1550-6606
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836399034884947969 |
|---|---|
| autor | Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. |
| beschreibung | Tissue-resident CD8 + T cells (T rm ) can rapidly eliminate virally infected cells, but their heterogeneous spatial distribution may leave gaps in protection within tissues. Although T rm patrol prior sites of viral replication, murine studies suggest they do not redistribute to adjacent uninfected sites to provide wider protection. We perform mathematical modeling of HSV-2 shedding in Homo sapiens and predict that infection does not induce enough T rm in many genital tract regions to eliminate shedding; a strict spatial distribution pattern of mucosal CD8 + T cell density is maintained throughout chronic infection, and trafficking of T rm across wide genital tract areas is unlikely. These predictions are confirmed with spatial analysis of CD8 + T cell distribution in histopathologic specimens from human genital biopsies. Further simulations predict that the key mechanistic correlate of protection following therapeutic HSV-2 vaccination would be an increase in total T rm rather than spatial reassortment of these cells. The fixed spatial structure of T rm induced by HSV-2 is sufficient for rapid elimination of infected cells but only in a portion of genital tract microregions. |
| citation_standardnr | 6321762 |
| datenlieferant | ipn_articles |
| feed_id | 333 |
| feed_publisher | The American Association of Immunologists (AAI) |
| feed_publisher_url | http://www.aai.org/ |
| insertion_date | 2018-08-21 |
| journaleissn | 1550-6606 |
| journalissn | 0022-1767 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Association of Immunologists (AAI) |
| quelle | Journal of Immunology |
| relation | http://www.jimmunol.org/cgi/content/short/201/5/1522?rss=1 |
| search_space | articles |
| shingle_author_1 | Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. |
| shingle_author_2 | Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. |
| shingle_author_3 | Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. |
| shingle_author_4 | Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. |
| shingle_catch_all_1 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] Tissue-resident CD8 + T cells (T rm ) can rapidly eliminate virally infected cells, but their heterogeneous spatial distribution may leave gaps in protection within tissues. Although T rm patrol prior sites of viral replication, murine studies suggest they do not redistribute to adjacent uninfected sites to provide wider protection. We perform mathematical modeling of HSV-2 shedding in Homo sapiens and predict that infection does not induce enough T rm in many genital tract regions to eliminate shedding; a strict spatial distribution pattern of mucosal CD8 + T cell density is maintained throughout chronic infection, and trafficking of T rm across wide genital tract areas is unlikely. These predictions are confirmed with spatial analysis of CD8 + T cell distribution in histopathologic specimens from human genital biopsies. Further simulations predict that the key mechanistic correlate of protection following therapeutic HSV-2 vaccination would be an increase in total T rm rather than spatial reassortment of these cells. The fixed spatial structure of T rm induced by HSV-2 is sufficient for rapid elimination of infected cells but only in a portion of genital tract microregions. Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_2 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] Tissue-resident CD8 + T cells (T rm ) can rapidly eliminate virally infected cells, but their heterogeneous spatial distribution may leave gaps in protection within tissues. Although T rm patrol prior sites of viral replication, murine studies suggest they do not redistribute to adjacent uninfected sites to provide wider protection. We perform mathematical modeling of HSV-2 shedding in Homo sapiens and predict that infection does not induce enough T rm in many genital tract regions to eliminate shedding; a strict spatial distribution pattern of mucosal CD8 + T cell density is maintained throughout chronic infection, and trafficking of T rm across wide genital tract areas is unlikely. These predictions are confirmed with spatial analysis of CD8 + T cell distribution in histopathologic specimens from human genital biopsies. Further simulations predict that the key mechanistic correlate of protection following therapeutic HSV-2 vaccination would be an increase in total T rm rather than spatial reassortment of these cells. The fixed spatial structure of T rm induced by HSV-2 is sufficient for rapid elimination of infected cells but only in a portion of genital tract microregions. Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_3 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] Tissue-resident CD8 + T cells (T rm ) can rapidly eliminate virally infected cells, but their heterogeneous spatial distribution may leave gaps in protection within tissues. Although T rm patrol prior sites of viral replication, murine studies suggest they do not redistribute to adjacent uninfected sites to provide wider protection. We perform mathematical modeling of HSV-2 shedding in Homo sapiens and predict that infection does not induce enough T rm in many genital tract regions to eliminate shedding; a strict spatial distribution pattern of mucosal CD8 + T cell density is maintained throughout chronic infection, and trafficking of T rm across wide genital tract areas is unlikely. These predictions are confirmed with spatial analysis of CD8 + T cell distribution in histopathologic specimens from human genital biopsies. Further simulations predict that the key mechanistic correlate of protection following therapeutic HSV-2 vaccination would be an increase in total T rm rather than spatial reassortment of these cells. The fixed spatial structure of T rm induced by HSV-2 is sufficient for rapid elimination of infected cells but only in a portion of genital tract microregions. Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_4 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] Tissue-resident CD8 + T cells (T rm ) can rapidly eliminate virally infected cells, but their heterogeneous spatial distribution may leave gaps in protection within tissues. Although T rm patrol prior sites of viral replication, murine studies suggest they do not redistribute to adjacent uninfected sites to provide wider protection. We perform mathematical modeling of HSV-2 shedding in Homo sapiens and predict that infection does not induce enough T rm in many genital tract regions to eliminate shedding; a strict spatial distribution pattern of mucosal CD8 + T cell density is maintained throughout chronic infection, and trafficking of T rm across wide genital tract areas is unlikely. These predictions are confirmed with spatial analysis of CD8 + T cell distribution in histopathologic specimens from human genital biopsies. Further simulations predict that the key mechanistic correlate of protection following therapeutic HSV-2 vaccination would be an increase in total T rm rather than spatial reassortment of these cells. The fixed spatial structure of T rm induced by HSV-2 is sufficient for rapid elimination of infected cells but only in a portion of genital tract microregions. Schiffer, J. T., Swan, D. A., Roychoudhury, P., Lund, J. M., Prlic, M., Zhu, J., Wald, A., Corey, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_title_1 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] |
| shingle_title_2 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] |
| shingle_title_3 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] |
| shingle_title_4 | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] |
| timestamp | 2025-06-30T23:36:30.752Z |
| titel | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] |
| titel_suche | A Fixed Spatial Structure of CD8+ T Cells in Tissue during Chronic HSV-2 Infection [MUCOSAL IMMUNOLOGY] |
| topic | WW-YZ |
| uid | ipn_articles_6321762 |