Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION]
Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A.
The American Association of Immunologists (AAI)
Published 2018
The American Association of Immunologists (AAI)
Published 2018
| Publication Date: |
2018-08-21
|
|---|---|
| Publisher: |
The American Association of Immunologists (AAI)
|
| Print ISSN: |
0022-1767
|
| Electronic ISSN: |
1550-6606
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836399034859782144 |
|---|---|
| autor | Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. |
| beschreibung | Glucose-derived mannose is a common component of glycoproteins, and its deficiency leads to a severe defect in protein glycosylation and failure in basic cell functions. In this work, we show that mannose metabolism is essential for IFN- production by mouse Th1 cells. In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN- expression. This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions. |
| citation_standardnr | 6321750 |
| datenlieferant | ipn_articles |
| feed_id | 333 |
| feed_publisher | The American Association of Immunologists (AAI) |
| feed_publisher_url | http://www.aai.org/ |
| insertion_date | 2018-08-21 |
| journaleissn | 1550-6606 |
| journalissn | 0022-1767 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Association of Immunologists (AAI) |
| quelle | Journal of Immunology |
| relation | http://www.jimmunol.org/cgi/content/short/201/5/1400?rss=1 |
| search_space | articles |
| shingle_author_1 | Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. |
| shingle_author_2 | Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. |
| shingle_author_3 | Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. |
| shingle_author_4 | Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. |
| shingle_catch_all_1 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] Glucose-derived mannose is a common component of glycoproteins, and its deficiency leads to a severe defect in protein glycosylation and failure in basic cell functions. In this work, we show that mannose metabolism is essential for IFN- production by mouse Th1 cells. In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN- expression. This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions. Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_2 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] Glucose-derived mannose is a common component of glycoproteins, and its deficiency leads to a severe defect in protein glycosylation and failure in basic cell functions. In this work, we show that mannose metabolism is essential for IFN- production by mouse Th1 cells. In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN- expression. This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions. Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_3 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] Glucose-derived mannose is a common component of glycoproteins, and its deficiency leads to a severe defect in protein glycosylation and failure in basic cell functions. In this work, we show that mannose metabolism is essential for IFN- production by mouse Th1 cells. In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN- expression. This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions. Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_4 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] Glucose-derived mannose is a common component of glycoproteins, and its deficiency leads to a severe defect in protein glycosylation and failure in basic cell functions. In this work, we show that mannose metabolism is essential for IFN- production by mouse Th1 cells. In addition, we demonstrate that the susceptibility of Th1 cells to glycolysis restriction depends on the activation conditions and that under diminished glycolytic flux, mannose availability becomes the limiting factor for IFN- expression. This study unravels a new role for glucose metabolism in the differentiation process of Th1 cells, providing a mechanistic explanation for the importance of glycolysis in immune cell functions. Zygmunt, B. M., Wegrzyn, A., Gajska, W., Yevsa, T., Chodaczek, G., Guzman, C. A. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_title_1 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] |
| shingle_title_2 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] |
| shingle_title_3 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] |
| shingle_title_4 | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] |
| timestamp | 2025-06-30T23:36:30.752Z |
| titel | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] |
| titel_suche | Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-{gamma} Production [IMMUNE REGULATION] |
| topic | WW-YZ |
| uid | ipn_articles_6321750 |