Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat

Publication Date:
2018-08-18
Publisher:
American Association for the Advancement of Science (AAAS)
Electronic ISSN:
2375-2548
Topics:
Natural Sciences in General
Published by:
http://www.aaas.org/
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autor Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
beschreibung Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
citation_standardnr 6321356
datenlieferant ipn_articles
feed_id 228416
feed_publisher American Association for the Advancement of Science (AAAS)
feed_publisher_url http://www.aaas.org/
insertion_date 2018-08-18
journaleissn 2375-2548
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Association for the Advancement of Science (AAAS)
quelle Science Advances
relation http://advances.sciencemag.org/cgi/content/short/4/8/eaar8602?rss=1
search_space articles
shingle_author_1 Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
shingle_author_2 Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
shingle_author_3 Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
shingle_author_4 Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
shingle_catch_all_1 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_2 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_3 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_4 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
Wheat is an important staple grain for humankind globally because of its end-use quality and nutritional properties and its adaptability to diverse climates. For a small proportion of the population, specific wheat proteins can trigger adverse immune responses and clinical manifestations such as celiac disease, wheat allergy, baker’s asthma, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Establishing the content and distribution of the immunostimulatory regions in wheat has been hampered by the complexity of the wheat genome and the lack of complete genome sequence information. We provide novel insights into the wheat grain proteins based on a comprehensive analysis and annotation of the wheat prolamin Pfam clan grain proteins and other non-prolamin allergens implicated in these disorders using the new International Wheat Genome Sequencing Consortium bread wheat reference genome sequence, RefSeq v1.0. Celiac disease and WDEIA genes are primarily expressed in the starchy endosperm and show wide variation in protein- and transcript-level expression in response to temperature stress. Nonspecific lipid transfer proteins and α-amylase trypsin inhibitor gene families, implicated in baker’s asthma, are primarily expressed in the aleurone layer and transfer cells of grains and are more sensitive to cold temperature. The study establishes a new reference map for immunostimulatory wheat proteins and provides a fresh basis for selecting wheat lines and developing diagnostics for products with more favorable consumer attributes.
Juhasz, A., Belova, T., Florides, C. G., Maulis, C., Fischer, I., Gell, G., Birinyi, Z., Ong, J., Keeble-Gagnere, G., Maharajan, A., Ma, W., Gibson, P., Jia, J., Lang, D., Mayer, K. F. X., Spannagl, M., International Wheat Genome Sequencing Consortium, Tye-Din, J. A., Appels, R., Olsen, O.-A.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_title_1 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
shingle_title_2 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
shingle_title_3 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
shingle_title_4 Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
timestamp 2025-06-30T23:36:30.752Z
titel Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
titel_suche Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
topic TA-TD
uid ipn_articles_6321356