The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]

Publication Date:
2018-08-02
Publisher:
Cold Spring Harbor Laboratory Press
Print ISSN:
0890-9369
Topics:
Biology
Published by:
http://www.cshlpress.com/
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autor Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
beschreibung RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. Ribosome profiling and RNA sequencing identified IMP1 as a principle node for gene expression regulation downstream from LIN28B . In vitro and in vivo data demonstrate that epithelial IMP1 loss increases expression of WNT target genes and enhances LIN28B-mediated intestinal tumorigenesis, which was reversed when we overexpressed IMP1 independently in vivo. Furthermore, IMP1 loss in wild-type or LIN28B-overexpressing mice enhances the regenerative response to irradiation. Together, our data provide new evidence for the opposing effects of the LIN28B–IMP1 axis on post-transcriptional regulation of canonical WNT signaling, with implications in intestinal homeostasis, regeneration and tumorigenesis.
citation_standardnr 6313013
datenlieferant ipn_articles
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feed_publisher Cold Spring Harbor Laboratory Press
feed_publisher_url http://www.cshlpress.com/
insertion_date 2018-08-02
journalissn 0890-9369
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Cold Spring Harbor Laboratory Press
quelle Genes & Development
relation http://genesdev.cshlp.org/cgi/content/short/32/15-16/1020?rss=1
search_space articles
shingle_author_1 Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
shingle_author_2 Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
shingle_author_3 Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
shingle_author_4 Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
shingle_catch_all_1 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. Ribosome profiling and RNA sequencing identified IMP1 as a principle node for gene expression regulation downstream from LIN28B . In vitro and in vivo data demonstrate that epithelial IMP1 loss increases expression of WNT target genes and enhances LIN28B-mediated intestinal tumorigenesis, which was reversed when we overexpressed IMP1 independently in vivo. Furthermore, IMP1 loss in wild-type or LIN28B-overexpressing mice enhances the regenerative response to irradiation. Together, our data provide new evidence for the opposing effects of the LIN28B–IMP1 axis on post-transcriptional regulation of canonical WNT signaling, with implications in intestinal homeostasis, regeneration and tumorigenesis.
Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_catch_all_2 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. Ribosome profiling and RNA sequencing identified IMP1 as a principle node for gene expression regulation downstream from LIN28B . In vitro and in vivo data demonstrate that epithelial IMP1 loss increases expression of WNT target genes and enhances LIN28B-mediated intestinal tumorigenesis, which was reversed when we overexpressed IMP1 independently in vivo. Furthermore, IMP1 loss in wild-type or LIN28B-overexpressing mice enhances the regenerative response to irradiation. Together, our data provide new evidence for the opposing effects of the LIN28B–IMP1 axis on post-transcriptional regulation of canonical WNT signaling, with implications in intestinal homeostasis, regeneration and tumorigenesis.
Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_catch_all_3 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. Ribosome profiling and RNA sequencing identified IMP1 as a principle node for gene expression regulation downstream from LIN28B . In vitro and in vivo data demonstrate that epithelial IMP1 loss increases expression of WNT target genes and enhances LIN28B-mediated intestinal tumorigenesis, which was reversed when we overexpressed IMP1 independently in vivo. Furthermore, IMP1 loss in wild-type or LIN28B-overexpressing mice enhances the regenerative response to irradiation. Together, our data provide new evidence for the opposing effects of the LIN28B–IMP1 axis on post-transcriptional regulation of canonical WNT signaling, with implications in intestinal homeostasis, regeneration and tumorigenesis.
Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_catch_all_4 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. Ribosome profiling and RNA sequencing identified IMP1 as a principle node for gene expression regulation downstream from LIN28B . In vitro and in vivo data demonstrate that epithelial IMP1 loss increases expression of WNT target genes and enhances LIN28B-mediated intestinal tumorigenesis, which was reversed when we overexpressed IMP1 independently in vivo. Furthermore, IMP1 loss in wild-type or LIN28B-overexpressing mice enhances the regenerative response to irradiation. Together, our data provide new evidence for the opposing effects of the LIN28B–IMP1 axis on post-transcriptional regulation of canonical WNT signaling, with implications in intestinal homeostasis, regeneration and tumorigenesis.
Chatterji, P., Hamilton, K. E., Liang, S., Andres, S. F., Wijeratne, H. R. S., Mizuno, R., Simon, L. A., Hicks, P. D., Foley, S. W., Pitarresi, J. R., Klein-Szanto, A. J., Mah, A. T., Van Landeghem, L., Gregory, B. D., Lengner, C. J., Madison, B. B., Shah, P., Rustgi, A. K.
Cold Spring Harbor Laboratory Press
0890-9369
08909369
shingle_title_1 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
shingle_title_2 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
shingle_title_3 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
shingle_title_4 The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
timestamp 2025-06-30T23:36:19.830Z
titel The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
titel_suche The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine [Research Papers]
topic W
uid ipn_articles_6313013