Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]

Publication Date:
2018-07-18
Publisher:
American Heart Association (AHA)
Print ISSN:
1941-9651
Electronic ISSN:
1942-0080
Topics:
Medicine
Keywords:
Computerized Tomography (CT), Prognosis
Published by:
http://www.americanheart.org/
_version_ 1836399007178424320
autor Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
beschreibung Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and Results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography 〉2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P 〈0.05). After risk adjustment, addition of baseline PB improved prediction of rapid progression to each angiographic assessment of coronary artery disease, and the presence of high-risk plaque further improved the predictive performance (all P 〈0.001). For prediction of adverse outcomes, adding both baseline PB and PB/y showed best predictive performance (C statistics, 0.763; P 〈0.001). Conclusions: Direct quantification of atherosclerotic PB in addition to conventional angiographic assessment of coronary artery disease might be beneficial for improving risk stratification of coronary artery disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02803411.
citation_standardnr 6305274
datenlieferant ipn_articles
feed_id 109339
feed_publisher American Heart Association (AHA)
feed_publisher_url http://www.americanheart.org/
insertion_date 2018-07-18
journaleissn 1942-0080
journalissn 1941-9651
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Heart Association (AHA)
quelle Circulation: Cardiovascular Imaging
relation http://circimaging.ahajournals.org/cgi/content/short/11/7/e007562?rss=1
schlagwort Computerized Tomography (CT), Prognosis
search_space articles
shingle_author_1 Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
shingle_author_2 Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
shingle_author_3 Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
shingle_author_4 Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
shingle_catch_all_1 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
Computerized Tomography (CT), Prognosis
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and Results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P <0.05). After risk adjustment, addition of baseline PB improved prediction of rapid progression to each angiographic assessment of coronary artery disease, and the presence of high-risk plaque further improved the predictive performance (all P <0.001). For prediction of adverse outcomes, adding both baseline PB and PB/y showed best predictive performance (C statistics, 0.763; P <0.001). Conclusions: Direct quantification of atherosclerotic PB in addition to conventional angiographic assessment of coronary artery disease might be beneficial for improving risk stratification of coronary artery disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02803411.
Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_2 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
Computerized Tomography (CT), Prognosis
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and Results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P <0.05). After risk adjustment, addition of baseline PB improved prediction of rapid progression to each angiographic assessment of coronary artery disease, and the presence of high-risk plaque further improved the predictive performance (all P <0.001). For prediction of adverse outcomes, adding both baseline PB and PB/y showed best predictive performance (C statistics, 0.763; P <0.001). Conclusions: Direct quantification of atherosclerotic PB in addition to conventional angiographic assessment of coronary artery disease might be beneficial for improving risk stratification of coronary artery disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02803411.
Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_3 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
Computerized Tomography (CT), Prognosis
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and Results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P <0.05). After risk adjustment, addition of baseline PB improved prediction of rapid progression to each angiographic assessment of coronary artery disease, and the presence of high-risk plaque further improved the predictive performance (all P <0.001). For prediction of adverse outcomes, adding both baseline PB and PB/y showed best predictive performance (C statistics, 0.763; P <0.001). Conclusions: Direct quantification of atherosclerotic PB in addition to conventional angiographic assessment of coronary artery disease might be beneficial for improving risk stratification of coronary artery disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02803411.
Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_4 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
Computerized Tomography (CT), Prognosis
Background: Diagnosis of coronary artery disease and management strategies have relied solely on the presence of diameter stenosis ≥50%. We assessed whether direct quantification of plaque burden (PB) and plaque characteristics assessed by coronary computed tomography angiography could provide additional value in terms of predicting rapid plaque progression. Methods and Results: From a 13-center, 7-country prospective observational registry, 1345 patients (60.4±9.4 years old; 57.1% male) who underwent repeated coronary computed tomography angiography >2 years apart were enrolled. For conventional angiographic analysis, the presence of stenosis ≥50%, number of vessel involved, segment involvement score, and the presence of high-risk plaque feature were determined. For quantitative analyses, PB and annual change in PB (PB/y) in the entire coronary tree were assessed. Clinical outcomes (cardiac death, nonfatal myocardial infarction, and coronary revascularization) were recorded. Rapid progressors, defined as a patient with ≥median value of PB/y (0.33%/y), were older, more frequently male, and had more clinical risk factors than nonrapid progressors (all P <0.05). After risk adjustment, addition of baseline PB improved prediction of rapid progression to each angiographic assessment of coronary artery disease, and the presence of high-risk plaque further improved the predictive performance (all P <0.001). For prediction of adverse outcomes, adding both baseline PB and PB/y showed best predictive performance (C statistics, 0.763; P <0.001). Conclusions: Direct quantification of atherosclerotic PB in addition to conventional angiographic assessment of coronary artery disease might be beneficial for improving risk stratification of coronary artery disease. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02803411.
Lee, S.-E., Sung, J. M., Rizvi, A., Lin, F. Y., Kumar, A., Hadamitzky, M., Kim, Y.-J., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Lee, B. K., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., Leipsic, J. A., Shin, S., Hyun Choi, J., Chinnaiyan, K., Raff, G., Virmani, R., Samady, H., Stone, P. H., Berman, D. S., Narula, J., Shaw, L. J., Bax, J. J., Min, J. K., Chang, H.-J.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_title_1 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
shingle_title_2 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
shingle_title_3 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
shingle_title_4 Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
timestamp 2025-06-30T23:36:07.579Z
titel Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
titel_suche Quantification of Coronary Atherosclerosis in the Assessment of Coronary Artery Disease [Coronary Artery Disease]
topic WW-YZ
uid ipn_articles_6305274