Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview]
Solanki, M., Pointon, A., Jones, B., Herbert, K.
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
Published 2018
| Publication Date: |
2018-06-30
|
|---|---|
| Publisher: |
The American Society for Pharmacology and Experimental Therapeutics (ASPET)
|
| Print ISSN: |
0090-9556
|
| Electronic ISSN: |
1521-009X
|
| Topics: |
Chemistry and Pharmacology
Medicine
|
| Published by: |
| _version_ | 1836398990990508032 |
|---|---|
| autor | Solanki, M., Pointon, A., Jones, B., Herbert, K. |
| beschreibung | Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). The biologic effects of EETs, including their protective effects on inflammation and vasodilation, are diverse because, in part, of their ability to act on a variety of cell types. In addition, CYP2J2 metabolizes both exogenous and endogenous substrates and is involved in phase 1 metabolism of a variety of structurally diverse compounds, including some antihistamines, anticancer agents, and immunosuppressants. This review addresses current understanding of the role of CYP2J2 in the metabolism of xenobiotics and endogenous AA, focusing on the effects on the cardiovascular system. In particular, we have promoted here the hypothesis that CYP2J2 influences drug-induced cardiotoxicity through potentially conflicting effects on the production of protective EETs and the metabolism of drugs. |
| citation_standardnr | 6295467 |
| datenlieferant | ipn_articles |
| feed_id | 1915 |
| feed_publisher | The American Society for Pharmacology and Experimental Therapeutics (ASPET) |
| feed_publisher_url | http://www.aspet.org/ |
| insertion_date | 2018-06-30 |
| journaleissn | 1521-009X |
| journalissn | 0090-9556 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Society for Pharmacology and Experimental Therapeutics (ASPET) |
| quelle | Drug Metabolism and Disposition |
| relation | http://dmd.aspetjournals.org/cgi/content/short/46/8/1053?rss=1 |
| search_space | articles |
| shingle_author_1 | Solanki, M., Pointon, A., Jones, B., Herbert, K. |
| shingle_author_2 | Solanki, M., Pointon, A., Jones, B., Herbert, K. |
| shingle_author_3 | Solanki, M., Pointon, A., Jones, B., Herbert, K. |
| shingle_author_4 | Solanki, M., Pointon, A., Jones, B., Herbert, K. |
| shingle_catch_all_1 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). The biologic effects of EETs, including their protective effects on inflammation and vasodilation, are diverse because, in part, of their ability to act on a variety of cell types. In addition, CYP2J2 metabolizes both exogenous and endogenous substrates and is involved in phase 1 metabolism of a variety of structurally diverse compounds, including some antihistamines, anticancer agents, and immunosuppressants. This review addresses current understanding of the role of CYP2J2 in the metabolism of xenobiotics and endogenous AA, focusing on the effects on the cardiovascular system. In particular, we have promoted here the hypothesis that CYP2J2 influences drug-induced cardiotoxicity through potentially conflicting effects on the production of protective EETs and the metabolism of drugs. Solanki, M., Pointon, A., Jones, B., Herbert, K. The American Society for Pharmacology and Experimental Therapeutics (ASPET) 0090-9556 00909556 1521-009X 1521009X |
| shingle_catch_all_2 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). The biologic effects of EETs, including their protective effects on inflammation and vasodilation, are diverse because, in part, of their ability to act on a variety of cell types. In addition, CYP2J2 metabolizes both exogenous and endogenous substrates and is involved in phase 1 metabolism of a variety of structurally diverse compounds, including some antihistamines, anticancer agents, and immunosuppressants. This review addresses current understanding of the role of CYP2J2 in the metabolism of xenobiotics and endogenous AA, focusing on the effects on the cardiovascular system. In particular, we have promoted here the hypothesis that CYP2J2 influences drug-induced cardiotoxicity through potentially conflicting effects on the production of protective EETs and the metabolism of drugs. Solanki, M., Pointon, A., Jones, B., Herbert, K. The American Society for Pharmacology and Experimental Therapeutics (ASPET) 0090-9556 00909556 1521-009X 1521009X |
| shingle_catch_all_3 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). The biologic effects of EETs, including their protective effects on inflammation and vasodilation, are diverse because, in part, of their ability to act on a variety of cell types. In addition, CYP2J2 metabolizes both exogenous and endogenous substrates and is involved in phase 1 metabolism of a variety of structurally diverse compounds, including some antihistamines, anticancer agents, and immunosuppressants. This review addresses current understanding of the role of CYP2J2 in the metabolism of xenobiotics and endogenous AA, focusing on the effects on the cardiovascular system. In particular, we have promoted here the hypothesis that CYP2J2 influences drug-induced cardiotoxicity through potentially conflicting effects on the production of protective EETs and the metabolism of drugs. Solanki, M., Pointon, A., Jones, B., Herbert, K. The American Society for Pharmacology and Experimental Therapeutics (ASPET) 0090-9556 00909556 1521-009X 1521009X |
| shingle_catch_all_4 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)–derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). The biologic effects of EETs, including their protective effects on inflammation and vasodilation, are diverse because, in part, of their ability to act on a variety of cell types. In addition, CYP2J2 metabolizes both exogenous and endogenous substrates and is involved in phase 1 metabolism of a variety of structurally diverse compounds, including some antihistamines, anticancer agents, and immunosuppressants. This review addresses current understanding of the role of CYP2J2 in the metabolism of xenobiotics and endogenous AA, focusing on the effects on the cardiovascular system. In particular, we have promoted here the hypothesis that CYP2J2 influences drug-induced cardiotoxicity through potentially conflicting effects on the production of protective EETs and the metabolism of drugs. Solanki, M., Pointon, A., Jones, B., Herbert, K. The American Society for Pharmacology and Experimental Therapeutics (ASPET) 0090-9556 00909556 1521-009X 1521009X |
| shingle_title_1 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] |
| shingle_title_2 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] |
| shingle_title_3 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] |
| shingle_title_4 | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] |
| timestamp | 2025-06-30T23:35:51.966Z |
| titel | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] |
| titel_suche | Cytochrome P450 2J2: Potential Role in Drug Metabolism and Cardiotoxicity [Minireview] |
| topic | V WW-YZ |
| uid | ipn_articles_6295467 |