MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD
Publication Date: |
2018-06-22
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Publisher: |
American Society of Hematology (ASH)
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Print ISSN: |
0006-4971
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Electronic ISSN: |
1528-0020
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Topics: |
Biology
Medicine
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Keywords: |
Transplantation, Free Research Articles, CME article, Clinical Trials and Observations
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Published by: |
_version_ | 1836398981243994112 |
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autor | Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. |
beschreibung | Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immunosuppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate predictive tests are urgently needed. We analyzed clinical data and blood samples taken 1 week after systemic treatment of GVHD from 507 patients from 17 centers of the Mount Sinai Acute GVHD International Consortium (MAGIC), dividing them into a test cohort (n = 236) and 2 validation cohorts separated in time (n = 142 and n = 129). Initial response to systemic steroids correlated with response at 4 weeks, 1-year nonrelapse mortality (NRM), and overall survival (OS). A previously validated algorithm of 2 MAGIC biomarkers (ST2 and REG3α) consistently separated steroid-resistant patients into 2 groups with dramatically different NRM and OS ( P 〈 .001 for all 3 cohorts). High biomarker probability, resistance to steroids, and GVHD severity (Minnesota risk) were all significant predictors of NRM in multivariate analysis. A direct comparison of receiver operating characteristic curves showed that the area under the curve for biomarker probability (0.82) was significantly greater than that for steroid response (0.68, P = .004) and for Minnesota risk (0.72, P = .005). In conclusion, MAGIC biomarker probabilities generated after 1 week of systemic treatment of GVHD predict long-term outcomes in steroid-resistant GVHD better than clinical criteria and should prove useful in developing better treatment strategies. |
citation_standardnr | 6289603 |
datenlieferant | ipn_articles |
feed_id | 310 |
feed_publisher | American Society of Hematology (ASH) |
feed_publisher_url | http://www.hematology.org/ |
insertion_date | 2018-06-22 |
journaleissn | 1528-0020 |
journalissn | 0006-4971 |
publikationsjahr_anzeige | 2018 |
publikationsjahr_facette | 2018 |
publikationsjahr_intervall | 7984:2015-2019 |
publikationsjahr_sort | 2018 |
publisher | American Society of Hematology (ASH) |
quelle | Blood |
relation | http://www.bloodjournal.org/cgi/content/short/131/25/2846?rss=1 |
schlagwort | Transplantation, Free Research Articles, CME article, Clinical Trials and Observations |
search_space | articles |
shingle_author_1 | Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. |
shingle_author_2 | Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. |
shingle_author_3 | Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. |
shingle_author_4 | Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. |
shingle_catch_all_1 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD Transplantation, Free Research Articles, CME article, Clinical Trials and Observations Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immunosuppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate predictive tests are urgently needed. We analyzed clinical data and blood samples taken 1 week after systemic treatment of GVHD from 507 patients from 17 centers of the Mount Sinai Acute GVHD International Consortium (MAGIC), dividing them into a test cohort (n = 236) and 2 validation cohorts separated in time (n = 142 and n = 129). Initial response to systemic steroids correlated with response at 4 weeks, 1-year nonrelapse mortality (NRM), and overall survival (OS). A previously validated algorithm of 2 MAGIC biomarkers (ST2 and REG3α) consistently separated steroid-resistant patients into 2 groups with dramatically different NRM and OS ( P < .001 for all 3 cohorts). High biomarker probability, resistance to steroids, and GVHD severity (Minnesota risk) were all significant predictors of NRM in multivariate analysis. A direct comparison of receiver operating characteristic curves showed that the area under the curve for biomarker probability (0.82) was significantly greater than that for steroid response (0.68, P = .004) and for Minnesota risk (0.72, P = .005). In conclusion, MAGIC biomarker probabilities generated after 1 week of systemic treatment of GVHD predict long-term outcomes in steroid-resistant GVHD better than clinical criteria and should prove useful in developing better treatment strategies. Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
shingle_catch_all_2 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD Transplantation, Free Research Articles, CME article, Clinical Trials and Observations Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immunosuppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate predictive tests are urgently needed. We analyzed clinical data and blood samples taken 1 week after systemic treatment of GVHD from 507 patients from 17 centers of the Mount Sinai Acute GVHD International Consortium (MAGIC), dividing them into a test cohort (n = 236) and 2 validation cohorts separated in time (n = 142 and n = 129). Initial response to systemic steroids correlated with response at 4 weeks, 1-year nonrelapse mortality (NRM), and overall survival (OS). A previously validated algorithm of 2 MAGIC biomarkers (ST2 and REG3α) consistently separated steroid-resistant patients into 2 groups with dramatically different NRM and OS ( P < .001 for all 3 cohorts). High biomarker probability, resistance to steroids, and GVHD severity (Minnesota risk) were all significant predictors of NRM in multivariate analysis. A direct comparison of receiver operating characteristic curves showed that the area under the curve for biomarker probability (0.82) was significantly greater than that for steroid response (0.68, P = .004) and for Minnesota risk (0.72, P = .005). In conclusion, MAGIC biomarker probabilities generated after 1 week of systemic treatment of GVHD predict long-term outcomes in steroid-resistant GVHD better than clinical criteria and should prove useful in developing better treatment strategies. Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
shingle_catch_all_3 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD Transplantation, Free Research Articles, CME article, Clinical Trials and Observations Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immunosuppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate predictive tests are urgently needed. We analyzed clinical data and blood samples taken 1 week after systemic treatment of GVHD from 507 patients from 17 centers of the Mount Sinai Acute GVHD International Consortium (MAGIC), dividing them into a test cohort (n = 236) and 2 validation cohorts separated in time (n = 142 and n = 129). Initial response to systemic steroids correlated with response at 4 weeks, 1-year nonrelapse mortality (NRM), and overall survival (OS). A previously validated algorithm of 2 MAGIC biomarkers (ST2 and REG3α) consistently separated steroid-resistant patients into 2 groups with dramatically different NRM and OS ( P < .001 for all 3 cohorts). High biomarker probability, resistance to steroids, and GVHD severity (Minnesota risk) were all significant predictors of NRM in multivariate analysis. A direct comparison of receiver operating characteristic curves showed that the area under the curve for biomarker probability (0.82) was significantly greater than that for steroid response (0.68, P = .004) and for Minnesota risk (0.72, P = .005). In conclusion, MAGIC biomarker probabilities generated after 1 week of systemic treatment of GVHD predict long-term outcomes in steroid-resistant GVHD better than clinical criteria and should prove useful in developing better treatment strategies. Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
shingle_catch_all_4 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD Transplantation, Free Research Articles, CME article, Clinical Trials and Observations Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid immunosuppression. Clinical response after 1 week of therapy often guides further treatment decisions, but long-term outcomes vary widely among centers, and more accurate predictive tests are urgently needed. We analyzed clinical data and blood samples taken 1 week after systemic treatment of GVHD from 507 patients from 17 centers of the Mount Sinai Acute GVHD International Consortium (MAGIC), dividing them into a test cohort (n = 236) and 2 validation cohorts separated in time (n = 142 and n = 129). Initial response to systemic steroids correlated with response at 4 weeks, 1-year nonrelapse mortality (NRM), and overall survival (OS). A previously validated algorithm of 2 MAGIC biomarkers (ST2 and REG3α) consistently separated steroid-resistant patients into 2 groups with dramatically different NRM and OS ( P < .001 for all 3 cohorts). High biomarker probability, resistance to steroids, and GVHD severity (Minnesota risk) were all significant predictors of NRM in multivariate analysis. A direct comparison of receiver operating characteristic curves showed that the area under the curve for biomarker probability (0.82) was significantly greater than that for steroid response (0.68, P = .004) and for Minnesota risk (0.72, P = .005). In conclusion, MAGIC biomarker probabilities generated after 1 week of systemic treatment of GVHD predict long-term outcomes in steroid-resistant GVHD better than clinical criteria and should prove useful in developing better treatment strategies. Major-Monfried, H., Renteria, A. S., Pawarode, A., Reddy, P., Ayuk, F., Holler, E., Efebera, Y. A., Hogan, W. J., Wölfl, M., Qayed, M., Hexner, E. O., Wudhikarn, K., Ordemann, R., Young, R., Shah, J., Hartwell, M. J., Chaudhry, M. S., Aziz, M., Etra, A., Yanik, G. A., Kröger, N., Weber, D., Chen, Y.-B., Nakamura, R., Rösler, W., Kitko, C. L., Harris, A. C., Pulsipher, M., Reshef, R., Kowalyk, S., Morales, G., Torres, I., Özbek, U., Ferrara, J. L. M., Levine, J. E. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
shingle_title_1 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD |
shingle_title_2 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD |
shingle_title_3 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD |
shingle_title_4 | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD |
timestamp | 2025-06-30T23:35:42.902Z |
titel | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD |
titel_suche | MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD |
topic | W WW-YZ |
uid | ipn_articles_6289603 |