Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES]
Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E.
The American Association of Immunologists (AAI)
Published 2018
The American Association of Immunologists (AAI)
Published 2018
| Publication Date: |
2018-06-05
|
|---|---|
| Publisher: |
The American Association of Immunologists (AAI)
|
| Print ISSN: |
0022-1767
|
| Electronic ISSN: |
1550-6606
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398960449683456 |
|---|---|
| autor | Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. |
| beschreibung | Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. |
| citation_standardnr | 6276285 |
| datenlieferant | ipn_articles |
| feed_id | 333 |
| feed_publisher | The American Association of Immunologists (AAI) |
| feed_publisher_url | http://www.aai.org/ |
| insertion_date | 2018-06-05 |
| journaleissn | 1550-6606 |
| journalissn | 0022-1767 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Association of Immunologists (AAI) |
| quelle | Journal of Immunology |
| relation | http://www.jimmunol.org/cgi/content/short/200/12/4068?rss=1 |
| search_space | articles |
| shingle_author_1 | Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. |
| shingle_author_2 | Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. |
| shingle_author_3 | Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. |
| shingle_author_4 | Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. |
| shingle_catch_all_1 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_2 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_3 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_4 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] Influenza is a major health threat, and a broadly protective influenza vaccine would be a significant advance. Signal Minus FLU (S-FLU) is a candidate broadly protective influenza vaccine that is limited to a single cycle of replication, which induces a strong cross-reactive T cell response but a minimal Ab response to hemagglutinin after intranasal or aerosol administration. We tested whether an H3N2 S-FLU can protect pigs and ferrets from heterosubtypic H1N1 influenza challenge. Aerosol administration of S-FLU to pigs induced lung tissue-resident memory T cells and reduced lung pathology but not the viral load. In contrast, in ferrets, S-FLU reduced viral replication and aerosol transmission. Our data show that S-FLU has different protective efficacy in pigs and ferrets, and that in the absence of Ab, lung T cell immunity can reduce disease severity without reducing challenge viral replication. Holzer, B., Morgan, S. B., Matsuoka, Y., Edmans, M., Salguero, F. J., Everett, H., Brookes, S. M., Porter, E., Mac; Loughlin, R., Charleston, B., Subbarao, K., Townsend, A., Tchilian, E. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_title_1 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] |
| shingle_title_2 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] |
| shingle_title_3 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] |
| shingle_title_4 | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] |
| timestamp | 2025-06-30T23:35:22.819Z |
| titel | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] |
| titel_suche | Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine [IMMUNOTHERAPY AND VACCINES] |
| topic | WW-YZ |
| uid | ipn_articles_6276285 |