Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION]
Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T.
The American Association of Immunologists (AAI)
Published 2018
The American Association of Immunologists (AAI)
Published 2018
| Publication Date: |
2018-06-05
|
|---|---|
| Publisher: |
The American Association of Immunologists (AAI)
|
| Print ISSN: |
0022-1767
|
| Electronic ISSN: |
1550-6606
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398960582852608 |
|---|---|
| autor | Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. |
| beschreibung | Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellular matrix interactions, play an important role in facilitating Treg cell contact–mediated suppression. In this article, we show that integrin activation plays an essential, previously unappreciated role in maintaining murine Treg cell function. Treg cell–specific loss of talin, a β integrin–binding protein, or expression of talin(L325R), a mutant that selectively abrogates integrin activation, resulted in lethal systemic autoimmunity. This dysfunction could be attributed, in part, to a global dysregulation of the Treg cell transcriptome. Activation of integrin α 4 β 1 led to increased suppressive capacity of the Treg cell pool, suggesting that modulating integrin activation on Treg cells may be a useful therapeutic strategy for autoimmune and inflammatory disorders. Taken together, these results reveal a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function. |
| citation_standardnr | 6276280 |
| datenlieferant | ipn_articles |
| feed_id | 333 |
| feed_publisher | The American Association of Immunologists (AAI) |
| feed_publisher_url | http://www.aai.org/ |
| insertion_date | 2018-06-05 |
| journaleissn | 1550-6606 |
| journalissn | 0022-1767 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Association of Immunologists (AAI) |
| quelle | Journal of Immunology |
| relation | http://www.jimmunol.org/cgi/content/short/200/12/4012?rss=1 |
| search_space | articles |
| shingle_author_1 | Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. |
| shingle_author_2 | Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. |
| shingle_author_3 | Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. |
| shingle_author_4 | Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. |
| shingle_catch_all_1 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellular matrix interactions, play an important role in facilitating Treg cell contact–mediated suppression. In this article, we show that integrin activation plays an essential, previously unappreciated role in maintaining murine Treg cell function. Treg cell–specific loss of talin, a β integrin–binding protein, or expression of talin(L325R), a mutant that selectively abrogates integrin activation, resulted in lethal systemic autoimmunity. This dysfunction could be attributed, in part, to a global dysregulation of the Treg cell transcriptome. Activation of integrin α 4 β 1 led to increased suppressive capacity of the Treg cell pool, suggesting that modulating integrin activation on Treg cells may be a useful therapeutic strategy for autoimmune and inflammatory disorders. Taken together, these results reveal a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function. Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_2 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellular matrix interactions, play an important role in facilitating Treg cell contact–mediated suppression. In this article, we show that integrin activation plays an essential, previously unappreciated role in maintaining murine Treg cell function. Treg cell–specific loss of talin, a β integrin–binding protein, or expression of talin(L325R), a mutant that selectively abrogates integrin activation, resulted in lethal systemic autoimmunity. This dysfunction could be attributed, in part, to a global dysregulation of the Treg cell transcriptome. Activation of integrin α 4 β 1 led to increased suppressive capacity of the Treg cell pool, suggesting that modulating integrin activation on Treg cells may be a useful therapeutic strategy for autoimmune and inflammatory disorders. Taken together, these results reveal a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function. Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_3 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellular matrix interactions, play an important role in facilitating Treg cell contact–mediated suppression. In this article, we show that integrin activation plays an essential, previously unappreciated role in maintaining murine Treg cell function. Treg cell–specific loss of talin, a β integrin–binding protein, or expression of talin(L325R), a mutant that selectively abrogates integrin activation, resulted in lethal systemic autoimmunity. This dysfunction could be attributed, in part, to a global dysregulation of the Treg cell transcriptome. Activation of integrin α 4 β 1 led to increased suppressive capacity of the Treg cell pool, suggesting that modulating integrin activation on Treg cells may be a useful therapeutic strategy for autoimmune and inflammatory disorders. Taken together, these results reveal a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function. Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_4 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] Maintenance of the regulatory T (Treg) cell pool is essential for peripheral tolerance and prevention of autoimmunity. Integrins, heterodimeric transmembrane proteins consisting of α and β subunits that mediate cell-to-cell and cell-to-extracellular matrix interactions, play an important role in facilitating Treg cell contact–mediated suppression. In this article, we show that integrin activation plays an essential, previously unappreciated role in maintaining murine Treg cell function. Treg cell–specific loss of talin, a β integrin–binding protein, or expression of talin(L325R), a mutant that selectively abrogates integrin activation, resulted in lethal systemic autoimmunity. This dysfunction could be attributed, in part, to a global dysregulation of the Treg cell transcriptome. Activation of integrin α 4 β 1 led to increased suppressive capacity of the Treg cell pool, suggesting that modulating integrin activation on Treg cells may be a useful therapeutic strategy for autoimmune and inflammatory disorders. Taken together, these results reveal a critical role for integrin-mediated signals in controlling peripheral tolerance by virtue of maintaining Treg cell function. Klann, J. E., Kim, S. H., Remedios, K. A., He, Z., Metz, P. J., Lopez, J., Tysl, T., Olvera, J. G., Ablack, J. N., Cantor, J. M., Boland, B. S., Yeo, G., Zheng, Y., Lu, L.-F., Bui, J. D., Ginsberg, M. H., Petrich, B. G., Chang, J. T. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_title_1 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] |
| shingle_title_2 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] |
| shingle_title_3 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] |
| shingle_title_4 | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] |
| timestamp | 2025-06-30T23:35:19.981Z |
| titel | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] |
| titel_suche | Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance [IMMUNE REGULATION] |
| topic | WW-YZ |
| uid | ipn_articles_6276280 |