Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]

Publication Date:
2018-05-30
Publisher:
Genetics Society of America (GSA)
Print ISSN:
0016-6731
Topics:
Biology
Published by:
http://www.genetics-gsa.org/
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autor Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
beschreibung Sterility in hybrid animals is widely known to be due to a cytological mechanism of aberrant homologous chromosome pairing during meiosis in hybrid germ cells. In this study, the gametes of four marine fish species belonging to the Sciaenid family were artificially fertilized, and germ cell development was examined at the cellular and molecular levels. One of the intergeneric hybrids had gonads that were testis-like in structure, small in size, and lacked germ cells. Specification of primordial germ cells (PGCs) and their migration toward genital ridges occurred normally in hybrid embryos, but these PGCs did not proliferate in the hybrid gonads. By germ cell transplantation assay, we showed that the gonadal microenvironment in hybrid recipients produced functional donor-derived gametes, suggesting that the germ cell-less phenotype was caused by cell autonomous proliferative defects of hybrid PGCs. This is the first evidence of mitotic arrest of germ cells causing hybrid sterility in animals.
citation_standardnr 6270738
datenlieferant ipn_articles
feed_id 2584
feed_publisher Genetics Society of America (GSA)
feed_publisher_url http://www.genetics-gsa.org/
insertion_date 2018-05-30
journalissn 0016-6731
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Genetics Society of America (GSA)
quelle Genetics
relation http://www.genetics.org/cgi/content/short/209/2/507?rss=1
search_space articles
shingle_author_1 Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
shingle_author_2 Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
shingle_author_3 Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
shingle_author_4 Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
shingle_catch_all_1 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
Sterility in hybrid animals is widely known to be due to a cytological mechanism of aberrant homologous chromosome pairing during meiosis in hybrid germ cells. In this study, the gametes of four marine fish species belonging to the Sciaenid family were artificially fertilized, and germ cell development was examined at the cellular and molecular levels. One of the intergeneric hybrids had gonads that were testis-like in structure, small in size, and lacked germ cells. Specification of primordial germ cells (PGCs) and their migration toward genital ridges occurred normally in hybrid embryos, but these PGCs did not proliferate in the hybrid gonads. By germ cell transplantation assay, we showed that the gonadal microenvironment in hybrid recipients produced functional donor-derived gametes, suggesting that the germ cell-less phenotype was caused by cell autonomous proliferative defects of hybrid PGCs. This is the first evidence of mitotic arrest of germ cells causing hybrid sterility in animals.
Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_catch_all_2 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
Sterility in hybrid animals is widely known to be due to a cytological mechanism of aberrant homologous chromosome pairing during meiosis in hybrid germ cells. In this study, the gametes of four marine fish species belonging to the Sciaenid family were artificially fertilized, and germ cell development was examined at the cellular and molecular levels. One of the intergeneric hybrids had gonads that were testis-like in structure, small in size, and lacked germ cells. Specification of primordial germ cells (PGCs) and their migration toward genital ridges occurred normally in hybrid embryos, but these PGCs did not proliferate in the hybrid gonads. By germ cell transplantation assay, we showed that the gonadal microenvironment in hybrid recipients produced functional donor-derived gametes, suggesting that the germ cell-less phenotype was caused by cell autonomous proliferative defects of hybrid PGCs. This is the first evidence of mitotic arrest of germ cells causing hybrid sterility in animals.
Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_catch_all_3 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
Sterility in hybrid animals is widely known to be due to a cytological mechanism of aberrant homologous chromosome pairing during meiosis in hybrid germ cells. In this study, the gametes of four marine fish species belonging to the Sciaenid family were artificially fertilized, and germ cell development was examined at the cellular and molecular levels. One of the intergeneric hybrids had gonads that were testis-like in structure, small in size, and lacked germ cells. Specification of primordial germ cells (PGCs) and their migration toward genital ridges occurred normally in hybrid embryos, but these PGCs did not proliferate in the hybrid gonads. By germ cell transplantation assay, we showed that the gonadal microenvironment in hybrid recipients produced functional donor-derived gametes, suggesting that the germ cell-less phenotype was caused by cell autonomous proliferative defects of hybrid PGCs. This is the first evidence of mitotic arrest of germ cells causing hybrid sterility in animals.
Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_catch_all_4 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
Sterility in hybrid animals is widely known to be due to a cytological mechanism of aberrant homologous chromosome pairing during meiosis in hybrid germ cells. In this study, the gametes of four marine fish species belonging to the Sciaenid family were artificially fertilized, and germ cell development was examined at the cellular and molecular levels. One of the intergeneric hybrids had gonads that were testis-like in structure, small in size, and lacked germ cells. Specification of primordial germ cells (PGCs) and their migration toward genital ridges occurred normally in hybrid embryos, but these PGCs did not proliferate in the hybrid gonads. By germ cell transplantation assay, we showed that the gonadal microenvironment in hybrid recipients produced functional donor-derived gametes, suggesting that the germ cell-less phenotype was caused by cell autonomous proliferative defects of hybrid PGCs. This is the first evidence of mitotic arrest of germ cells causing hybrid sterility in animals.
Yoshikawa, H., Xu, D., Ino, Y., Yoshino, T., Hayashida, T., Wang, J., Yazawa, R., Yoshizaki, G., Takeuchi, Y.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_title_1 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
shingle_title_2 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
shingle_title_3 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
shingle_title_4 Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
timestamp 2025-06-30T23:35:12.238Z
titel Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
titel_suche Hybrid Sterility in Fish Caused by Mitotic Arrest of Primordial Germ Cells [Genetics of Sex]
topic W
uid ipn_articles_6270738