Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow

Publication Date:
2018-05-24
Publisher:
American Association for the Advancement of Science (AAAS)
Electronic ISSN:
2375-2548
Topics:
Natural Sciences in General
Published by:
http://www.aaas.org/
_version_ 1836398941907714049
autor De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
beschreibung Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum gametocytes are present in circulation, whereas immature forms accumulate in the hematopoietic environment of the bone marrow. We used the rodent model Plasmodium berghei to study gametocyte behavior through time under physiological conditions. Intravital microscopy demonstrated preferential homing of early gametocyte forms across the intact vascular barrier of the bone marrow and the spleen early during infection and subsequent development in the extravascular environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering and exiting the intact vascular barrier. We suggest that extravascular gametocyte localization and mobility are essential for gametocytogenesis and transmission of Plasmodium to the mosquito.
citation_standardnr 6265983
datenlieferant ipn_articles
feed_id 228416
feed_publisher American Association for the Advancement of Science (AAAS)
feed_publisher_url http://www.aaas.org/
insertion_date 2018-05-24
journaleissn 2375-2548
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Association for the Advancement of Science (AAAS)
quelle Science Advances
relation http://advances.sciencemag.org/cgi/content/short/4/5/eaat3775?rss=1
search_space articles
shingle_author_1 De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
shingle_author_2 De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
shingle_author_3 De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
shingle_author_4 De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
shingle_catch_all_1 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum gametocytes are present in circulation, whereas immature forms accumulate in the hematopoietic environment of the bone marrow. We used the rodent model Plasmodium berghei to study gametocyte behavior through time under physiological conditions. Intravital microscopy demonstrated preferential homing of early gametocyte forms across the intact vascular barrier of the bone marrow and the spleen early during infection and subsequent development in the extravascular environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering and exiting the intact vascular barrier. We suggest that extravascular gametocyte localization and mobility are essential for gametocytogenesis and transmission of Plasmodium to the mosquito.
De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_2 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum gametocytes are present in circulation, whereas immature forms accumulate in the hematopoietic environment of the bone marrow. We used the rodent model Plasmodium berghei to study gametocyte behavior through time under physiological conditions. Intravital microscopy demonstrated preferential homing of early gametocyte forms across the intact vascular barrier of the bone marrow and the spleen early during infection and subsequent development in the extravascular environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering and exiting the intact vascular barrier. We suggest that extravascular gametocyte localization and mobility are essential for gametocytogenesis and transmission of Plasmodium to the mosquito.
De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_3 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum gametocytes are present in circulation, whereas immature forms accumulate in the hematopoietic environment of the bone marrow. We used the rodent model Plasmodium berghei to study gametocyte behavior through time under physiological conditions. Intravital microscopy demonstrated preferential homing of early gametocyte forms across the intact vascular barrier of the bone marrow and the spleen early during infection and subsequent development in the extravascular environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering and exiting the intact vascular barrier. We suggest that extravascular gametocyte localization and mobility are essential for gametocytogenesis and transmission of Plasmodium to the mosquito.
De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_catch_all_4 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falciparum gametocytes are present in circulation, whereas immature forms accumulate in the hematopoietic environment of the bone marrow. We used the rodent model Plasmodium berghei to study gametocyte behavior through time under physiological conditions. Intravital microscopy demonstrated preferential homing of early gametocyte forms across the intact vascular barrier of the bone marrow and the spleen early during infection and subsequent development in the extravascular environment. During the acute phase of infection, we observed vascular leakage resulting in further parasite accumulation in this environment. Mature gametocytes showed high deformability and were found entering and exiting the intact vascular barrier. We suggest that extravascular gametocyte localization and mobility are essential for gametocytogenesis and transmission of Plasmodium to the mosquito.
De Niz, M., Meibalan, E., Mejia, P., Ma, S., Brancucci, N. M. B., Agop-Nersesian, C., Mandt, R., Ngotho, P., Hughes, K. R., Waters, A. P., Huttenhower, C., Mitchell, J. R., Martinelli, R., Frischknecht, F., Seydel, K. B., Taylor, T., Milner, D., Heussler, V. T., Marti, M.
American Association for the Advancement of Science (AAAS)
2375-2548
23752548
shingle_title_1 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
shingle_title_2 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
shingle_title_3 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
shingle_title_4 Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
timestamp 2025-06-30T23:35:05.469Z
titel Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
titel_suche Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow
topic TA-TD
uid ipn_articles_6265983