SOX11 augments BCR signaling to drive MCL-like tumor development
Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S.
American Society of Hematology (ASH)
Published 2018
American Society of Hematology (ASH)
Published 2018
| Publication Date: |
2018-05-18
|
|---|---|
| Publisher: |
American Society of Hematology (ASH)
|
| Print ISSN: |
0006-4971
|
| Electronic ISSN: |
1528-0020
|
| Topics: |
Biology
Medicine
|
| Keywords: |
Lymphoid Neoplasia
|
| Published by: |
| _version_ | 1836398932809220098 |
|---|---|
| autor | Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. |
| beschreibung | Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling, and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is overexpressed in the majority (78% to 93%) of MCL patients and is considered an MCL-specific oncogene. So far, attempts to understand SOX11 function in vivo have been hampered by the lack of appropriate animal models, because germline deletion of SOX11 is embryonically lethal. We have developed a transgenic mouse model (Eμ-SOX11-EGFP) in the C57BL/6 background expressing murine SOX11 and EGFP under the control of a B-cell–specific IgH-Eμ enhancer. The overexpression of SOX11 exclusively in B cells exhibits oligoclonal B-cell hyperplasia in the spleen, bone marrow, and peripheral blood, with an immunophenotype (CD5 + CD19 + CD23 – ) identical to human MCL. Furthermore, phosphocytometric time-of-flight analysis of the splenocytes from these mice shows hyperactivation of pBTK and other molecules in the BCR signaling pathway, and serial bone marrow transplant from transgenic donors produces lethality with decreasing latency. We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL. |
| citation_standardnr | 6260882 |
| datenlieferant | ipn_articles |
| feed_id | 310 |
| feed_publisher | American Society of Hematology (ASH) |
| feed_publisher_url | http://www.hematology.org/ |
| insertion_date | 2018-05-18 |
| journaleissn | 1528-0020 |
| journalissn | 0006-4971 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | American Society of Hematology (ASH) |
| quelle | Blood |
| relation | http://www.bloodjournal.org/cgi/content/short/131/20/2247?rss=1 |
| schlagwort | Lymphoid Neoplasia |
| search_space | articles |
| shingle_author_1 | Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. |
| shingle_author_2 | Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. |
| shingle_author_3 | Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. |
| shingle_author_4 | Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. |
| shingle_catch_all_1 | SOX11 augments BCR signaling to drive MCL-like tumor development Lymphoid Neoplasia Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling, and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is overexpressed in the majority (78% to 93%) of MCL patients and is considered an MCL-specific oncogene. So far, attempts to understand SOX11 function in vivo have been hampered by the lack of appropriate animal models, because germline deletion of SOX11 is embryonically lethal. We have developed a transgenic mouse model (Eμ-SOX11-EGFP) in the C57BL/6 background expressing murine SOX11 and EGFP under the control of a B-cell–specific IgH-Eμ enhancer. The overexpression of SOX11 exclusively in B cells exhibits oligoclonal B-cell hyperplasia in the spleen, bone marrow, and peripheral blood, with an immunophenotype (CD5 + CD19 + CD23 – ) identical to human MCL. Furthermore, phosphocytometric time-of-flight analysis of the splenocytes from these mice shows hyperactivation of pBTK and other molecules in the BCR signaling pathway, and serial bone marrow transplant from transgenic donors produces lethality with decreasing latency. We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL. Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_catch_all_2 | SOX11 augments BCR signaling to drive MCL-like tumor development Lymphoid Neoplasia Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling, and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is overexpressed in the majority (78% to 93%) of MCL patients and is considered an MCL-specific oncogene. So far, attempts to understand SOX11 function in vivo have been hampered by the lack of appropriate animal models, because germline deletion of SOX11 is embryonically lethal. We have developed a transgenic mouse model (Eμ-SOX11-EGFP) in the C57BL/6 background expressing murine SOX11 and EGFP under the control of a B-cell–specific IgH-Eμ enhancer. The overexpression of SOX11 exclusively in B cells exhibits oligoclonal B-cell hyperplasia in the spleen, bone marrow, and peripheral blood, with an immunophenotype (CD5 + CD19 + CD23 – ) identical to human MCL. Furthermore, phosphocytometric time-of-flight analysis of the splenocytes from these mice shows hyperactivation of pBTK and other molecules in the BCR signaling pathway, and serial bone marrow transplant from transgenic donors produces lethality with decreasing latency. We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL. Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_catch_all_3 | SOX11 augments BCR signaling to drive MCL-like tumor development Lymphoid Neoplasia Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling, and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is overexpressed in the majority (78% to 93%) of MCL patients and is considered an MCL-specific oncogene. So far, attempts to understand SOX11 function in vivo have been hampered by the lack of appropriate animal models, because germline deletion of SOX11 is embryonically lethal. We have developed a transgenic mouse model (Eμ-SOX11-EGFP) in the C57BL/6 background expressing murine SOX11 and EGFP under the control of a B-cell–specific IgH-Eμ enhancer. The overexpression of SOX11 exclusively in B cells exhibits oligoclonal B-cell hyperplasia in the spleen, bone marrow, and peripheral blood, with an immunophenotype (CD5 + CD19 + CD23 – ) identical to human MCL. Furthermore, phosphocytometric time-of-flight analysis of the splenocytes from these mice shows hyperactivation of pBTK and other molecules in the BCR signaling pathway, and serial bone marrow transplant from transgenic donors produces lethality with decreasing latency. We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL. Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_catch_all_4 | SOX11 augments BCR signaling to drive MCL-like tumor development Lymphoid Neoplasia Mantle cell lymphoma (MCL) is characterized by increased B-cell receptor (BCR) signaling, and BTK inhibition is an effective therapeutic intervention in MCL patients. The mechanisms leading to increased BCR signaling in MCL are poorly understood, as mutations in upstream regulators of BCR signaling such as CD79A, commonly observed in other lymphomas, are rare in MCL. The transcription factor SOX11 is overexpressed in the majority (78% to 93%) of MCL patients and is considered an MCL-specific oncogene. So far, attempts to understand SOX11 function in vivo have been hampered by the lack of appropriate animal models, because germline deletion of SOX11 is embryonically lethal. We have developed a transgenic mouse model (Eμ-SOX11-EGFP) in the C57BL/6 background expressing murine SOX11 and EGFP under the control of a B-cell–specific IgH-Eμ enhancer. The overexpression of SOX11 exclusively in B cells exhibits oligoclonal B-cell hyperplasia in the spleen, bone marrow, and peripheral blood, with an immunophenotype (CD5 + CD19 + CD23 – ) identical to human MCL. Furthermore, phosphocytometric time-of-flight analysis of the splenocytes from these mice shows hyperactivation of pBTK and other molecules in the BCR signaling pathway, and serial bone marrow transplant from transgenic donors produces lethality with decreasing latency. We report here that overexpression of SOX11 in B cells promotes BCR signaling and a disease phenotype that mimics human MCL. Kuo, P.-Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H., Parekh, S. American Society of Hematology (ASH) 0006-4971 00064971 1528-0020 15280020 |
| shingle_title_1 | SOX11 augments BCR signaling to drive MCL-like tumor development |
| shingle_title_2 | SOX11 augments BCR signaling to drive MCL-like tumor development |
| shingle_title_3 | SOX11 augments BCR signaling to drive MCL-like tumor development |
| shingle_title_4 | SOX11 augments BCR signaling to drive MCL-like tumor development |
| timestamp | 2025-06-30T23:34:56.614Z |
| titel | SOX11 augments BCR signaling to drive MCL-like tumor development |
| titel_suche | SOX11 augments BCR signaling to drive MCL-like tumor development |
| topic | W WW-YZ |
| uid | ipn_articles_6260882 |