Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions
Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T.
BMJ Publishing Group
Published 2018
BMJ Publishing Group
Published 2018
| Publication Date: |
2018-05-17
|
|---|---|
| Publisher: |
BMJ Publishing Group
|
| Print ISSN: |
0021-9746
|
| Electronic ISSN: |
1472-4146
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1839208052589330433 |
|---|---|
| autor | Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. |
| beschreibung | Aims To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). Methods Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. Results Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misinterpreted as in situ carcinomas, whereas 4 ductal carcinoma in situ (DCIS) cases were overdiagnosed as invasive carcinoma. Microscopically, 163 tumours were in situ, including 136 DCIS, 19 lobular carcinomas in situ (LCIS) and 8 mixed DCIS/LCIS; of these carcinomas in situ (CIS), 37 had microinvasion. The DCIS group exhibited low, intermediate and high grades in 53.7%, 34.6% and 11.8% of cases, respectively, mostly with solid (43.4%) or cribriform (41.9%) pattern. Forty out of 43 invasive cases were invasive ductal carcinoma (IDC), mostly DCIS predominant. Immunophenotypically, luminal A phenotype was identified in 55.1%, 63.2% and 45.0% of DCIS, LCIS and IDC cases, respectively. Topographical type A group (carcinoma being entirely confined to SA, n=176) was characterised by smaller size, less invasiveness, lower grade and more frequency of luminal A immunophenotype compared with type B group (≥ 50% but not all of the carcinomatous lesion being located in SA, n=30) (all P〈0.05). Conclusions CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality. |
| citation_standardnr | 6260229 |
| datenlieferant | ipn_articles |
| feed_id | 8759 |
| feed_publisher | BMJ Publishing Group |
| feed_publisher_url | http://www.bmj.com/ |
| insertion_date | 2018-05-17 |
| journaleissn | 1472-4146 |
| journalissn | 0021-9746 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | BMJ Publishing Group |
| quelle | Journal of Clinical Pathology |
| relation | http://jcp.bmj.com/cgi/content/short/71/6/546?rss=1 |
| search_space | articles |
| shingle_author_1 | Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. |
| shingle_author_2 | Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. |
| shingle_author_3 | Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. |
| shingle_author_4 | Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. |
| shingle_catch_all_1 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions Aims To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). Methods Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. Results Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misinterpreted as in situ carcinomas, whereas 4 ductal carcinoma in situ (DCIS) cases were overdiagnosed as invasive carcinoma. Microscopically, 163 tumours were in situ, including 136 DCIS, 19 lobular carcinomas in situ (LCIS) and 8 mixed DCIS/LCIS; of these carcinomas in situ (CIS), 37 had microinvasion. The DCIS group exhibited low, intermediate and high grades in 53.7%, 34.6% and 11.8% of cases, respectively, mostly with solid (43.4%) or cribriform (41.9%) pattern. Forty out of 43 invasive cases were invasive ductal carcinoma (IDC), mostly DCIS predominant. Immunophenotypically, luminal A phenotype was identified in 55.1%, 63.2% and 45.0% of DCIS, LCIS and IDC cases, respectively. Topographical type A group (carcinoma being entirely confined to SA, n=176) was characterised by smaller size, less invasiveness, lower grade and more frequency of luminal A immunophenotype compared with type B group (≥ 50% but not all of the carcinomatous lesion being located in SA, n=30) (all P<0.05). Conclusions CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality. Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. BMJ Publishing Group 0021-9746 00219746 1472-4146 14724146 |
| shingle_catch_all_2 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions Aims To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). Methods Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. Results Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misinterpreted as in situ carcinomas, whereas 4 ductal carcinoma in situ (DCIS) cases were overdiagnosed as invasive carcinoma. Microscopically, 163 tumours were in situ, including 136 DCIS, 19 lobular carcinomas in situ (LCIS) and 8 mixed DCIS/LCIS; of these carcinomas in situ (CIS), 37 had microinvasion. The DCIS group exhibited low, intermediate and high grades in 53.7%, 34.6% and 11.8% of cases, respectively, mostly with solid (43.4%) or cribriform (41.9%) pattern. Forty out of 43 invasive cases were invasive ductal carcinoma (IDC), mostly DCIS predominant. Immunophenotypically, luminal A phenotype was identified in 55.1%, 63.2% and 45.0% of DCIS, LCIS and IDC cases, respectively. Topographical type A group (carcinoma being entirely confined to SA, n=176) was characterised by smaller size, less invasiveness, lower grade and more frequency of luminal A immunophenotype compared with type B group (≥ 50% but not all of the carcinomatous lesion being located in SA, n=30) (all P<0.05). Conclusions CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality. Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. BMJ Publishing Group 0021-9746 00219746 1472-4146 14724146 |
| shingle_catch_all_3 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions Aims To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). Methods Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. Results Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misinterpreted as in situ carcinomas, whereas 4 ductal carcinoma in situ (DCIS) cases were overdiagnosed as invasive carcinoma. Microscopically, 163 tumours were in situ, including 136 DCIS, 19 lobular carcinomas in situ (LCIS) and 8 mixed DCIS/LCIS; of these carcinomas in situ (CIS), 37 had microinvasion. The DCIS group exhibited low, intermediate and high grades in 53.7%, 34.6% and 11.8% of cases, respectively, mostly with solid (43.4%) or cribriform (41.9%) pattern. Forty out of 43 invasive cases were invasive ductal carcinoma (IDC), mostly DCIS predominant. Immunophenotypically, luminal A phenotype was identified in 55.1%, 63.2% and 45.0% of DCIS, LCIS and IDC cases, respectively. Topographical type A group (carcinoma being entirely confined to SA, n=176) was characterised by smaller size, less invasiveness, lower grade and more frequency of luminal A immunophenotype compared with type B group (≥ 50% but not all of the carcinomatous lesion being located in SA, n=30) (all P<0.05). Conclusions CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality. Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. BMJ Publishing Group 0021-9746 00219746 1472-4146 14724146 |
| shingle_catch_all_4 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions Aims To fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC). Methods Clinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed. Results Overall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misinterpreted as in situ carcinomas, whereas 4 ductal carcinoma in situ (DCIS) cases were overdiagnosed as invasive carcinoma. Microscopically, 163 tumours were in situ, including 136 DCIS, 19 lobular carcinomas in situ (LCIS) and 8 mixed DCIS/LCIS; of these carcinomas in situ (CIS), 37 had microinvasion. The DCIS group exhibited low, intermediate and high grades in 53.7%, 34.6% and 11.8% of cases, respectively, mostly with solid (43.4%) or cribriform (41.9%) pattern. Forty out of 43 invasive cases were invasive ductal carcinoma (IDC), mostly DCIS predominant. Immunophenotypically, luminal A phenotype was identified in 55.1%, 63.2% and 45.0% of DCIS, LCIS and IDC cases, respectively. Topographical type A group (carcinoma being entirely confined to SA, n=176) was characterised by smaller size, less invasiveness, lower grade and more frequency of luminal A immunophenotype compared with type B group (≥ 50% but not all of the carcinomatous lesion being located in SA, n=30) (all P<0.05). Conclusions CIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality. Yu, B.-H., Tang, S.-X., Xu, X.-L., Cheng, Y.-F., Bi, R., Shui, R.-H., Tu, X.-Y., Lu, H.-F., Zhou, X.-Y., Yang, W.-T. BMJ Publishing Group 0021-9746 00219746 1472-4146 14724146 |
| shingle_title_1 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions |
| shingle_title_2 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions |
| shingle_title_3 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions |
| shingle_title_4 | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions |
| timestamp | 2025-07-31T23:44:40.606Z |
| titel | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions |
| titel_suche | Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions |
| topic | WW-YZ |
| uid | ipn_articles_6260229 |