Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]

Publication Date:
2018-05-13
Publisher:
American Heart Association (AHA)
Print ISSN:
1941-9651
Electronic ISSN:
1942-0080
Topics:
Medicine
Keywords:
Biomarkers, Contractile Function, Cardiovascular Disease, Diabetes, Type 2, Echocardiography
Published by:
http://www.americanheart.org/
_version_ 1836398928411492352
autor Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
beschreibung Background: Diabetes mellitus and pre–diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. Methods and Results: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24.3±3.5 kg/m 2 ) with comprehensive echocardiography including speckle tracking for left ventricular global longitudinal strain/torsion, with plasma sugar, glycosylated hemoglobin (HbA1c), and insulin resistance (homeostasis model assessment of insulin resistance) obtained. Participants were classified as (1) nondiabetic (fasting glucose 〈100 mg/mL; HbA1c 〈5.7%; n=1416), prediabetic (fasting glucose 100–126 mg/dL; HbA1c 5.7%–6.4%; n=2029), or diabetic (n=505) and (2) lean (body mass index 〈23 kg/m 2 ; n=1445) or nonlean (n=2505). Higher sugar, HbA1c, and homeostasis model assessment of insulin resistance were independently associated with higher left ventricular mass, greater mass-to-volume ratio, more impaired diastolic indices, and worse global longitudinal strain even after adjusting for clinical covariates (adjusted coefficient value: 0.28/0.12 for global longitudinal strain per 1 U HbA1c/homeostasis model assessment of insulin resistance increment; both P 〈0.001), with a consistent trend toward greater torsion (all trend P 〈0.001). The optimal cutoffs in identifying subclinical systolic dysfunction (global longitudinal strain more impaired than –18%) for lean versus nonlean individuals were 97 versus 106 mg/dL for fasting sugar, 130 versus 135 mg/mL for postprandial sugar, 5.62% versus 6.28% for HbA1c, and 1.81 versus 2.40 for homeostasis model assessment of insulin resistance, respectively. Conclusions: These data demonstrate the presence of preclinical cardiac remodeling and systolic dysfunction in prediabetic and diabetic Chinese adults, occurring at lower thresholds of glycemic indices than defined by international standards, particularly in lean individuals.
citation_standardnr 6257430
datenlieferant ipn_articles
feed_id 109339
feed_publisher American Heart Association (AHA)
feed_publisher_url http://www.americanheart.org/
insertion_date 2018-05-13
journaleissn 1942-0080
journalissn 1941-9651
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Heart Association (AHA)
quelle Circulation: Cardiovascular Imaging
relation http://circimaging.ahajournals.org/cgi/content/short/11/5/e007047?rss=1
schlagwort Biomarkers, Contractile Function, Cardiovascular Disease, Diabetes, Type 2, Echocardiography
search_space articles
shingle_author_1 Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
shingle_author_2 Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
shingle_author_3 Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
shingle_author_4 Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
shingle_catch_all_1 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
Biomarkers, Contractile Function, Cardiovascular Disease, Diabetes, Type 2, Echocardiography
Background: Diabetes mellitus and pre–diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. Methods and Results: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24.3±3.5 kg/m 2 ) with comprehensive echocardiography including speckle tracking for left ventricular global longitudinal strain/torsion, with plasma sugar, glycosylated hemoglobin (HbA1c), and insulin resistance (homeostasis model assessment of insulin resistance) obtained. Participants were classified as (1) nondiabetic (fasting glucose <100 mg/mL; HbA1c <5.7%; n=1416), prediabetic (fasting glucose 100–126 mg/dL; HbA1c 5.7%–6.4%; n=2029), or diabetic (n=505) and (2) lean (body mass index <23 kg/m 2 ; n=1445) or nonlean (n=2505). Higher sugar, HbA1c, and homeostasis model assessment of insulin resistance were independently associated with higher left ventricular mass, greater mass-to-volume ratio, more impaired diastolic indices, and worse global longitudinal strain even after adjusting for clinical covariates (adjusted coefficient value: 0.28/0.12 for global longitudinal strain per 1 U HbA1c/homeostasis model assessment of insulin resistance increment; both P <0.001), with a consistent trend toward greater torsion (all trend P <0.001). The optimal cutoffs in identifying subclinical systolic dysfunction (global longitudinal strain more impaired than –18%) for lean versus nonlean individuals were 97 versus 106 mg/dL for fasting sugar, 130 versus 135 mg/mL for postprandial sugar, 5.62% versus 6.28% for HbA1c, and 1.81 versus 2.40 for homeostasis model assessment of insulin resistance, respectively. Conclusions: These data demonstrate the presence of preclinical cardiac remodeling and systolic dysfunction in prediabetic and diabetic Chinese adults, occurring at lower thresholds of glycemic indices than defined by international standards, particularly in lean individuals.
Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_2 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
Biomarkers, Contractile Function, Cardiovascular Disease, Diabetes, Type 2, Echocardiography
Background: Diabetes mellitus and pre–diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. Methods and Results: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24.3±3.5 kg/m 2 ) with comprehensive echocardiography including speckle tracking for left ventricular global longitudinal strain/torsion, with plasma sugar, glycosylated hemoglobin (HbA1c), and insulin resistance (homeostasis model assessment of insulin resistance) obtained. Participants were classified as (1) nondiabetic (fasting glucose <100 mg/mL; HbA1c <5.7%; n=1416), prediabetic (fasting glucose 100–126 mg/dL; HbA1c 5.7%–6.4%; n=2029), or diabetic (n=505) and (2) lean (body mass index <23 kg/m 2 ; n=1445) or nonlean (n=2505). Higher sugar, HbA1c, and homeostasis model assessment of insulin resistance were independently associated with higher left ventricular mass, greater mass-to-volume ratio, more impaired diastolic indices, and worse global longitudinal strain even after adjusting for clinical covariates (adjusted coefficient value: 0.28/0.12 for global longitudinal strain per 1 U HbA1c/homeostasis model assessment of insulin resistance increment; both P <0.001), with a consistent trend toward greater torsion (all trend P <0.001). The optimal cutoffs in identifying subclinical systolic dysfunction (global longitudinal strain more impaired than –18%) for lean versus nonlean individuals were 97 versus 106 mg/dL for fasting sugar, 130 versus 135 mg/mL for postprandial sugar, 5.62% versus 6.28% for HbA1c, and 1.81 versus 2.40 for homeostasis model assessment of insulin resistance, respectively. Conclusions: These data demonstrate the presence of preclinical cardiac remodeling and systolic dysfunction in prediabetic and diabetic Chinese adults, occurring at lower thresholds of glycemic indices than defined by international standards, particularly in lean individuals.
Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_3 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
Biomarkers, Contractile Function, Cardiovascular Disease, Diabetes, Type 2, Echocardiography
Background: Diabetes mellitus and pre–diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. Methods and Results: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24.3±3.5 kg/m 2 ) with comprehensive echocardiography including speckle tracking for left ventricular global longitudinal strain/torsion, with plasma sugar, glycosylated hemoglobin (HbA1c), and insulin resistance (homeostasis model assessment of insulin resistance) obtained. Participants were classified as (1) nondiabetic (fasting glucose <100 mg/mL; HbA1c <5.7%; n=1416), prediabetic (fasting glucose 100–126 mg/dL; HbA1c 5.7%–6.4%; n=2029), or diabetic (n=505) and (2) lean (body mass index <23 kg/m 2 ; n=1445) or nonlean (n=2505). Higher sugar, HbA1c, and homeostasis model assessment of insulin resistance were independently associated with higher left ventricular mass, greater mass-to-volume ratio, more impaired diastolic indices, and worse global longitudinal strain even after adjusting for clinical covariates (adjusted coefficient value: 0.28/0.12 for global longitudinal strain per 1 U HbA1c/homeostasis model assessment of insulin resistance increment; both P <0.001), with a consistent trend toward greater torsion (all trend P <0.001). The optimal cutoffs in identifying subclinical systolic dysfunction (global longitudinal strain more impaired than –18%) for lean versus nonlean individuals were 97 versus 106 mg/dL for fasting sugar, 130 versus 135 mg/mL for postprandial sugar, 5.62% versus 6.28% for HbA1c, and 1.81 versus 2.40 for homeostasis model assessment of insulin resistance, respectively. Conclusions: These data demonstrate the presence of preclinical cardiac remodeling and systolic dysfunction in prediabetic and diabetic Chinese adults, occurring at lower thresholds of glycemic indices than defined by international standards, particularly in lean individuals.
Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_4 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
Biomarkers, Contractile Function, Cardiovascular Disease, Diabetes, Type 2, Echocardiography
Background: Diabetes mellitus and pre–diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. Methods and Results: We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24.3±3.5 kg/m 2 ) with comprehensive echocardiography including speckle tracking for left ventricular global longitudinal strain/torsion, with plasma sugar, glycosylated hemoglobin (HbA1c), and insulin resistance (homeostasis model assessment of insulin resistance) obtained. Participants were classified as (1) nondiabetic (fasting glucose <100 mg/mL; HbA1c <5.7%; n=1416), prediabetic (fasting glucose 100–126 mg/dL; HbA1c 5.7%–6.4%; n=2029), or diabetic (n=505) and (2) lean (body mass index <23 kg/m 2 ; n=1445) or nonlean (n=2505). Higher sugar, HbA1c, and homeostasis model assessment of insulin resistance were independently associated with higher left ventricular mass, greater mass-to-volume ratio, more impaired diastolic indices, and worse global longitudinal strain even after adjusting for clinical covariates (adjusted coefficient value: 0.28/0.12 for global longitudinal strain per 1 U HbA1c/homeostasis model assessment of insulin resistance increment; both P <0.001), with a consistent trend toward greater torsion (all trend P <0.001). The optimal cutoffs in identifying subclinical systolic dysfunction (global longitudinal strain more impaired than –18%) for lean versus nonlean individuals were 97 versus 106 mg/dL for fasting sugar, 130 versus 135 mg/mL for postprandial sugar, 5.62% versus 6.28% for HbA1c, and 1.81 versus 2.40 for homeostasis model assessment of insulin resistance, respectively. Conclusions: These data demonstrate the presence of preclinical cardiac remodeling and systolic dysfunction in prediabetic and diabetic Chinese adults, occurring at lower thresholds of glycemic indices than defined by international standards, particularly in lean individuals.
Lin, J.-L., Sung, K.-T., Su, C.-H., Chou, T.-H., Lo, C.-I., Tsai, J.-P., Chang, S.-C., Lai, Y.-H., Hu, K.-C., Liu, C.-Y., Yun, C.-H., Hung, C.-L., Yeh, H.-I., Lam, C. S. P.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_title_1 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
shingle_title_2 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
shingle_title_3 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
shingle_title_4 Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
timestamp 2025-06-30T23:34:51.625Z
titel Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
titel_suche Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults [Ventricular Structure and Function]
topic WW-YZ
uid ipn_articles_6257430