Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]

Publication Date:
2018-05-13
Publisher:
American Heart Association (AHA)
Print ISSN:
1941-9651
Electronic ISSN:
1942-0080
Topics:
Medicine
Keywords:
Cardiomyopathy, Heart Failure, Echocardiography
Published by:
http://www.americanheart.org/
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autor Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
beschreibung Background: Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. Methods and Results: We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system. Reproducibility of SV, myocardial contraction fraction, and left ventricular strain was assessed in a separate, yet comparable, study cohort of 150 patients from the Pavia Amyloidosis Center. The echocardiographic measures most predictive for overall survival were SV index 〈33 mL/min, myocardial contraction fraction 〈34%, and cardiac index 〈2.4 L/min/m 2 with respective hazard ratios (95% confidence intervals) of 2.95 (2.37–3.66), 2.36 (1.96–2.85), and 2.32 (1.91–2.80). For the subset that had left ventricular strain performed, the prognostic cut point was –14% (hazard ratios, 2.70; 95% confidence intervals, 1.84–3.96). Each parameter was independent of systolic blood pressure, Mayo staging system (NT-proBNP [N-terminal pro-B-type natriuretic peptide] and troponin), and ejection fraction on multivariable analysis. Simple predictive models for survival, including biomarker staging along with SV index or left ventricular strain, were generated. Conclusions: SV index prognostic performance was similar to left ventricular strain in predicting survival in AL amyloidosis, independently of biomarker staging. Because SV index is routinely calculated and widely available, it could serve as the preferred echocardiographic measure to predict outcomes in AL amyloidosis patients.
citation_standardnr 6257428
datenlieferant ipn_articles
feed_id 109339
feed_publisher American Heart Association (AHA)
feed_publisher_url http://www.americanheart.org/
insertion_date 2018-05-13
journaleissn 1942-0080
journalissn 1941-9651
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Heart Association (AHA)
quelle Circulation: Cardiovascular Imaging
relation http://circimaging.ahajournals.org/cgi/content/short/11/5/e006588?rss=1
schlagwort Cardiomyopathy, Heart Failure, Echocardiography
search_space articles
shingle_author_1 Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
shingle_author_2 Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
shingle_author_3 Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
shingle_author_4 Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
shingle_catch_all_1 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
Cardiomyopathy, Heart Failure, Echocardiography
Background: Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. Methods and Results: We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system. Reproducibility of SV, myocardial contraction fraction, and left ventricular strain was assessed in a separate, yet comparable, study cohort of 150 patients from the Pavia Amyloidosis Center. The echocardiographic measures most predictive for overall survival were SV index <33 mL/min, myocardial contraction fraction <34%, and cardiac index <2.4 L/min/m 2 with respective hazard ratios (95% confidence intervals) of 2.95 (2.37–3.66), 2.36 (1.96–2.85), and 2.32 (1.91–2.80). For the subset that had left ventricular strain performed, the prognostic cut point was –14% (hazard ratios, 2.70; 95% confidence intervals, 1.84–3.96). Each parameter was independent of systolic blood pressure, Mayo staging system (NT-proBNP [N-terminal pro-B-type natriuretic peptide] and troponin), and ejection fraction on multivariable analysis. Simple predictive models for survival, including biomarker staging along with SV index or left ventricular strain, were generated. Conclusions: SV index prognostic performance was similar to left ventricular strain in predicting survival in AL amyloidosis, independently of biomarker staging. Because SV index is routinely calculated and widely available, it could serve as the preferred echocardiographic measure to predict outcomes in AL amyloidosis patients.
Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_2 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
Cardiomyopathy, Heart Failure, Echocardiography
Background: Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. Methods and Results: We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system. Reproducibility of SV, myocardial contraction fraction, and left ventricular strain was assessed in a separate, yet comparable, study cohort of 150 patients from the Pavia Amyloidosis Center. The echocardiographic measures most predictive for overall survival were SV index <33 mL/min, myocardial contraction fraction <34%, and cardiac index <2.4 L/min/m 2 with respective hazard ratios (95% confidence intervals) of 2.95 (2.37–3.66), 2.36 (1.96–2.85), and 2.32 (1.91–2.80). For the subset that had left ventricular strain performed, the prognostic cut point was –14% (hazard ratios, 2.70; 95% confidence intervals, 1.84–3.96). Each parameter was independent of systolic blood pressure, Mayo staging system (NT-proBNP [N-terminal pro-B-type natriuretic peptide] and troponin), and ejection fraction on multivariable analysis. Simple predictive models for survival, including biomarker staging along with SV index or left ventricular strain, were generated. Conclusions: SV index prognostic performance was similar to left ventricular strain in predicting survival in AL amyloidosis, independently of biomarker staging. Because SV index is routinely calculated and widely available, it could serve as the preferred echocardiographic measure to predict outcomes in AL amyloidosis patients.
Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_3 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
Cardiomyopathy, Heart Failure, Echocardiography
Background: Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. Methods and Results: We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system. Reproducibility of SV, myocardial contraction fraction, and left ventricular strain was assessed in a separate, yet comparable, study cohort of 150 patients from the Pavia Amyloidosis Center. The echocardiographic measures most predictive for overall survival were SV index <33 mL/min, myocardial contraction fraction <34%, and cardiac index <2.4 L/min/m 2 with respective hazard ratios (95% confidence intervals) of 2.95 (2.37–3.66), 2.36 (1.96–2.85), and 2.32 (1.91–2.80). For the subset that had left ventricular strain performed, the prognostic cut point was –14% (hazard ratios, 2.70; 95% confidence intervals, 1.84–3.96). Each parameter was independent of systolic blood pressure, Mayo staging system (NT-proBNP [N-terminal pro-B-type natriuretic peptide] and troponin), and ejection fraction on multivariable analysis. Simple predictive models for survival, including biomarker staging along with SV index or left ventricular strain, were generated. Conclusions: SV index prognostic performance was similar to left ventricular strain in predicting survival in AL amyloidosis, independently of biomarker staging. Because SV index is routinely calculated and widely available, it could serve as the preferred echocardiographic measure to predict outcomes in AL amyloidosis patients.
Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_catch_all_4 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
Cardiomyopathy, Heart Failure, Echocardiography
Background: Heart involvement is the most important prognostic determinant in AL amyloidosis patients. Echocardiography is a cornerstone for the diagnosis and provides important prognostic information. Methods and Results: We studied 754 patients with AL amyloidosis who underwent echocardiographic assessment at the Mayo Clinic, including a Doppler-derived measurement of stroke volume (SV) within 30 days of their diagnosis to explore the prognostic role of echocardiographic variables in the context of a well-established soluble cardiac biomarker staging system. Reproducibility of SV, myocardial contraction fraction, and left ventricular strain was assessed in a separate, yet comparable, study cohort of 150 patients from the Pavia Amyloidosis Center. The echocardiographic measures most predictive for overall survival were SV index <33 mL/min, myocardial contraction fraction <34%, and cardiac index <2.4 L/min/m 2 with respective hazard ratios (95% confidence intervals) of 2.95 (2.37–3.66), 2.36 (1.96–2.85), and 2.32 (1.91–2.80). For the subset that had left ventricular strain performed, the prognostic cut point was –14% (hazard ratios, 2.70; 95% confidence intervals, 1.84–3.96). Each parameter was independent of systolic blood pressure, Mayo staging system (NT-proBNP [N-terminal pro-B-type natriuretic peptide] and troponin), and ejection fraction on multivariable analysis. Simple predictive models for survival, including biomarker staging along with SV index or left ventricular strain, were generated. Conclusions: SV index prognostic performance was similar to left ventricular strain in predicting survival in AL amyloidosis, independently of biomarker staging. Because SV index is routinely calculated and widely available, it could serve as the preferred echocardiographic measure to predict outcomes in AL amyloidosis patients.
Milani, P., Dispenzieri, A., Scott, C. G., Gertz, M. A., Perlini, S., Mussinelli, R., Lacy, M. Q., Buadi, F. K., Kumar, S., Maurer, M. S., Merlini, G., Hayman, S. R., Leung, N., Dingli, D., Klarich, K. W., Lust, J. A., Lin, Y., Kapoor, P., Go, R. S., Pellikka, P. A., Hwa, Y. L., Zeldenrust, S. R., Kyle, R. A., Rajkumar, S. V., Grogan, M.
American Heart Association (AHA)
1941-9651
19419651
1942-0080
19420080
shingle_title_1 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
shingle_title_2 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
shingle_title_3 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
shingle_title_4 Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
timestamp 2025-06-30T23:34:51.625Z
titel Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
titel_suche Independent Prognostic Value of Stroke Volume Index in Patients With Immunoglobulin Light Chain Amyloidosis [Cardio-Oncology]
topic WW-YZ
uid ipn_articles_6257428