Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism

Publication Date:
2018-05-11
Publisher:
American Society of Hematology (ASH)
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
Medicine
Keywords:
Thrombosis and Hemostasis, Clinical Trials and Observations
Published by:
http://www.hematology.org/
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autor Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
beschreibung It is uncertain whether antiphospholipid antibodies (APAs) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin antibodies, anti–β2 glycoprotein 1 antibodies, and lupus anticoagulant on 2 occasions ~6 months apart in 307 patients with a first unprovoked VTE who were part of a prospective cohort study. We then determined if APAs were associated with recurrent thrombosis in the 290 patients who stopped anticoagulant therapy in response to negative D-dimer results. Compared with those without an APA, the hazard ratios for recurrent VTE were 1.8 (95% confidence interval [CI], 0.9-3.7; P = .09) in the 25.9% of patients with an APA on ≥1 occasions, 2.7 (95% CI, 1.1-.7; P = .03) in the 9.0% of patients with the same APA on 2 occasions, and 4.5 (95% CI, 1.5-13.0; P = .006) in the 3.8% of patients with 2 or 3 different APA types on either the same or different occasions. There was no association between having an APA and D-dimer levels. We conclude that having the same type of APA on 2 occasions or having 〉1 type of APA on the same or different occasions is associated with recurrent thrombosis in patients with a first unprovoked VTE who stop anticoagulant therapy in response to negative D-dimer tests. APA and D-dimer levels seem to be independent predictors of recurrence in patients with an unprovoked VTE. This trial was registered at www.clinicaltrials.gov as #NCT00720915.
citation_standardnr 6255536
datenlieferant ipn_articles
feed_id 310
feed_publisher American Society of Hematology (ASH)
feed_publisher_url http://www.hematology.org/
insertion_date 2018-05-11
journaleissn 1528-0020
journalissn 0006-4971
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Society of Hematology (ASH)
quelle Blood
relation http://www.bloodjournal.org/cgi/content/short/131/19/2151?rss=1
schlagwort Thrombosis and Hemostasis, Clinical Trials and Observations
search_space articles
shingle_author_1 Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
shingle_author_2 Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
shingle_author_3 Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
shingle_author_4 Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
shingle_catch_all_1 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
Thrombosis and Hemostasis, Clinical Trials and Observations
It is uncertain whether antiphospholipid antibodies (APAs) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin antibodies, anti–β2 glycoprotein 1 antibodies, and lupus anticoagulant on 2 occasions ~6 months apart in 307 patients with a first unprovoked VTE who were part of a prospective cohort study. We then determined if APAs were associated with recurrent thrombosis in the 290 patients who stopped anticoagulant therapy in response to negative D-dimer results. Compared with those without an APA, the hazard ratios for recurrent VTE were 1.8 (95% confidence interval [CI], 0.9-3.7; P = .09) in the 25.9% of patients with an APA on ≥1 occasions, 2.7 (95% CI, 1.1-.7; P = .03) in the 9.0% of patients with the same APA on 2 occasions, and 4.5 (95% CI, 1.5-13.0; P = .006) in the 3.8% of patients with 2 or 3 different APA types on either the same or different occasions. There was no association between having an APA and D-dimer levels. We conclude that having the same type of APA on 2 occasions or having >1 type of APA on the same or different occasions is associated with recurrent thrombosis in patients with a first unprovoked VTE who stop anticoagulant therapy in response to negative D-dimer tests. APA and D-dimer levels seem to be independent predictors of recurrence in patients with an unprovoked VTE. This trial was registered at www.clinicaltrials.gov as #NCT00720915.
Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_catch_all_2 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
Thrombosis and Hemostasis, Clinical Trials and Observations
It is uncertain whether antiphospholipid antibodies (APAs) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin antibodies, anti–β2 glycoprotein 1 antibodies, and lupus anticoagulant on 2 occasions ~6 months apart in 307 patients with a first unprovoked VTE who were part of a prospective cohort study. We then determined if APAs were associated with recurrent thrombosis in the 290 patients who stopped anticoagulant therapy in response to negative D-dimer results. Compared with those without an APA, the hazard ratios for recurrent VTE were 1.8 (95% confidence interval [CI], 0.9-3.7; P = .09) in the 25.9% of patients with an APA on ≥1 occasions, 2.7 (95% CI, 1.1-.7; P = .03) in the 9.0% of patients with the same APA on 2 occasions, and 4.5 (95% CI, 1.5-13.0; P = .006) in the 3.8% of patients with 2 or 3 different APA types on either the same or different occasions. There was no association between having an APA and D-dimer levels. We conclude that having the same type of APA on 2 occasions or having >1 type of APA on the same or different occasions is associated with recurrent thrombosis in patients with a first unprovoked VTE who stop anticoagulant therapy in response to negative D-dimer tests. APA and D-dimer levels seem to be independent predictors of recurrence in patients with an unprovoked VTE. This trial was registered at www.clinicaltrials.gov as #NCT00720915.
Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_catch_all_3 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
Thrombosis and Hemostasis, Clinical Trials and Observations
It is uncertain whether antiphospholipid antibodies (APAs) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin antibodies, anti–β2 glycoprotein 1 antibodies, and lupus anticoagulant on 2 occasions ~6 months apart in 307 patients with a first unprovoked VTE who were part of a prospective cohort study. We then determined if APAs were associated with recurrent thrombosis in the 290 patients who stopped anticoagulant therapy in response to negative D-dimer results. Compared with those without an APA, the hazard ratios for recurrent VTE were 1.8 (95% confidence interval [CI], 0.9-3.7; P = .09) in the 25.9% of patients with an APA on ≥1 occasions, 2.7 (95% CI, 1.1-.7; P = .03) in the 9.0% of patients with the same APA on 2 occasions, and 4.5 (95% CI, 1.5-13.0; P = .006) in the 3.8% of patients with 2 or 3 different APA types on either the same or different occasions. There was no association between having an APA and D-dimer levels. We conclude that having the same type of APA on 2 occasions or having >1 type of APA on the same or different occasions is associated with recurrent thrombosis in patients with a first unprovoked VTE who stop anticoagulant therapy in response to negative D-dimer tests. APA and D-dimer levels seem to be independent predictors of recurrence in patients with an unprovoked VTE. This trial was registered at www.clinicaltrials.gov as #NCT00720915.
Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_catch_all_4 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
Thrombosis and Hemostasis, Clinical Trials and Observations
It is uncertain whether antiphospholipid antibodies (APAs) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin antibodies, anti–β2 glycoprotein 1 antibodies, and lupus anticoagulant on 2 occasions ~6 months apart in 307 patients with a first unprovoked VTE who were part of a prospective cohort study. We then determined if APAs were associated with recurrent thrombosis in the 290 patients who stopped anticoagulant therapy in response to negative D-dimer results. Compared with those without an APA, the hazard ratios for recurrent VTE were 1.8 (95% confidence interval [CI], 0.9-3.7; P = .09) in the 25.9% of patients with an APA on ≥1 occasions, 2.7 (95% CI, 1.1-.7; P = .03) in the 9.0% of patients with the same APA on 2 occasions, and 4.5 (95% CI, 1.5-13.0; P = .006) in the 3.8% of patients with 2 or 3 different APA types on either the same or different occasions. There was no association between having an APA and D-dimer levels. We conclude that having the same type of APA on 2 occasions or having >1 type of APA on the same or different occasions is associated with recurrent thrombosis in patients with a first unprovoked VTE who stop anticoagulant therapy in response to negative D-dimer tests. APA and D-dimer levels seem to be independent predictors of recurrence in patients with an unprovoked VTE. This trial was registered at www.clinicaltrials.gov as #NCT00720915.
Kearon, C., Parpia, S., Spencer, F. A., Baglin, T., Stevens, S. M., Bauer, K. A., Lentz, S. R., Kessler, C. M., Douketis, J. D., Moll, S., Kaatz, S., Schulman, S., Connors, J. M., Ginsberg, J. S., Spadafora, L., Bhagirath, V., Liaw, P. C., Weitz, J. I., Julian, J. A.
American Society of Hematology (ASH)
0006-4971
00064971
1528-0020
15280020
shingle_title_1 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
shingle_title_2 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
shingle_title_3 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
shingle_title_4 Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
timestamp 2025-06-30T23:34:49.415Z
titel Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
titel_suche Antiphospholipid antibodies and recurrent thrombosis after a first unprovoked venous thromboembolism
topic W
WW-YZ
uid ipn_articles_6255536