Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

Publication Date:
2018-04-25
Publisher:
Nature Publishing Group (NPG)
Electronic ISSN:
2041-1723
Topics:
Biology
Chemistry and Pharmacology
Natural Sciences in General
Physics
Published by:
http://www.nature.com/
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autor Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
beschreibung Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease, Published online: 24 April 2018; doi:10.1038/s41467-018-03911-8 Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.
citation_standardnr 6243705
datenlieferant ipn_articles
feed_id 134647
feed_publisher Nature Publishing Group (NPG)
feed_publisher_url http://www.nature.com/
insertion_date 2018-04-25
journaleissn 2041-1723
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Nature Publishing Group (NPG)
quelle Nature Communications
relation http://feeds.nature.com/~r/ncomms/rss/current/~3/IyWLUUIXNKw/s41467-018-03911-8
search_space articles
shingle_author_1 Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
shingle_author_2 Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
shingle_author_3 Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
shingle_author_4 Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
shingle_catch_all_1 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease, Published online: 24 April 2018; doi:10.1038/s41467-018-03911-8 Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.
Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_2 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease, Published online: 24 April 2018; doi:10.1038/s41467-018-03911-8 Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.
Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_3 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease, Published online: 24 April 2018; doi:10.1038/s41467-018-03911-8 Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.
Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_catch_all_4 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease, Published online: 24 April 2018; doi:10.1038/s41467-018-03911-8 Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes.
Connor A. Emdin; Amit V. Khera; Mark Chaffin; Derek Klarin; Pradeep Natarajan; Krishna Aragam; Mary Haas; Alexander Bick; Seyedeh M. Zekavat; Akihiro Nomura; Diego Ardissino; James G. Wilson; Heribert Schunkert; Ruth McPherson; Hugh Watkins; Roberto Elosua; Matthew J. Bown; Nilesh J. Samani; Usman Baber; Jeanette Erdmann; Namrata Gupta; John Danesh; Daniel Chasman; Paul Ridker; Joshua Denny; Lisa Bastarache; Judith H. Lichtman; Gail D’Onofrio; Jennifer Mattera; John A. Spertus; Wayne H.-H. Sheu; Kent D. Taylor; Bruce M. Psaty; Stephen S. Rich; Wendy Post; Jerome I. Rotter; Yii-Der Ida Chen; Harlan Krumholz; Danish Saleheen; Stacey Gabriel; Sekar Kathiresan
Nature Publishing Group (NPG)
2041-1723
20411723
shingle_title_1 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
shingle_title_2 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
shingle_title_3 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
shingle_title_4 Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
timestamp 2025-06-30T23:34:32.888Z
titel Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
titel_suche Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease
topic W
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uid ipn_articles_6243705