Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews]
| Publication Date: |
2018-04-25
|
|---|---|
| Publisher: |
Cold Spring Harbor Laboratory Press
|
| Print ISSN: |
0890-9369
|
| Topics: |
Biology
|
| Keywords: |
Cell Biology, Neurobiology
|
| Published by: |
| _version_ | 1836398907664367616 |
|---|---|
| autor | O'Brown, N. M., Pfau, S. J., Gu, C. |
| beschreibung | The blood–brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases. |
| citation_standardnr | 6243538 |
| datenlieferant | ipn_articles |
| feed_id | 1644 |
| feed_publisher | Cold Spring Harbor Laboratory Press |
| feed_publisher_url | http://www.cshlpress.com/ |
| insertion_date | 2018-04-25 |
| journalissn | 0890-9369 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | Cold Spring Harbor Laboratory Press |
| quelle | Genes & Development |
| relation | http://genesdev.cshlp.org/cgi/content/short/32/7-8/466?rss=1 |
| schlagwort | Cell Biology, Neurobiology |
| search_space | articles |
| shingle_author_1 | O'Brown, N. M., Pfau, S. J., Gu, C. |
| shingle_author_2 | O'Brown, N. M., Pfau, S. J., Gu, C. |
| shingle_author_3 | O'Brown, N. M., Pfau, S. J., Gu, C. |
| shingle_author_4 | O'Brown, N. M., Pfau, S. J., Gu, C. |
| shingle_catch_all_1 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] Cell Biology, Neurobiology The blood–brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases. O'Brown, N. M., Pfau, S. J., Gu, C. Cold Spring Harbor Laboratory Press 0890-9369 08909369 |
| shingle_catch_all_2 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] Cell Biology, Neurobiology The blood–brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases. O'Brown, N. M., Pfau, S. J., Gu, C. Cold Spring Harbor Laboratory Press 0890-9369 08909369 |
| shingle_catch_all_3 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] Cell Biology, Neurobiology The blood–brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases. O'Brown, N. M., Pfau, S. J., Gu, C. Cold Spring Harbor Laboratory Press 0890-9369 08909369 |
| shingle_catch_all_4 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] Cell Biology, Neurobiology The blood–brain barrier (BBB) restricts free access of molecules between the blood and the brain and is essential for regulating the neural microenvironment. Here, we describe how the BBB was initially characterized and how the current field evaluates barrier properties. We next detail the cellular nature of the BBB and discuss both the conservation and variation of BBB function across taxa. Finally, we examine our current understanding of mouse and zebrafish model systems, as we expect that comparison of the BBB across organisms will provide insight into the human BBB under normal physiological conditions and in neurological diseases. O'Brown, N. M., Pfau, S. J., Gu, C. Cold Spring Harbor Laboratory Press 0890-9369 08909369 |
| shingle_title_1 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] |
| shingle_title_2 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] |
| shingle_title_3 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] |
| shingle_title_4 | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] |
| timestamp | 2025-06-30T23:34:32.888Z |
| titel | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] |
| titel_suche | Bridging barriers: a comparative look at the blood-brain barrier across organisms [Reviews] |
| topic | W |
| uid | ipn_articles_6243538 |