Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
The American Association of Immunologists (AAI)
Published 2018
The American Association of Immunologists (AAI)
Published 2018
| Publication Date: |
2018-04-24
|
|---|---|
| Publisher: |
The American Association of Immunologists (AAI)
|
| Print ISSN: |
0022-1767
|
| Electronic ISSN: |
1550-6606
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398906788806656 |
|---|---|
| autor | Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. |
| beschreibung | Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags. |
| citation_standardnr | 6242842 |
| datenlieferant | ipn_articles |
| feed_id | 333 |
| feed_publisher | The American Association of Immunologists (AAI) |
| feed_publisher_url | http://www.aai.org/ |
| insertion_date | 2018-04-24 |
| journaleissn | 1550-6606 |
| journalissn | 0022-1767 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Association of Immunologists (AAI) |
| quelle | Journal of Immunology |
| relation | http://www.jimmunol.org/cgi/content/short/200/9/3117?rss=1 |
| search_space | articles |
| shingle_author_1 | Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. |
| shingle_author_2 | Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. |
| shingle_author_3 | Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. |
| shingle_author_4 | Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. |
| shingle_catch_all_1 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags. Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_2 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags. Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_3 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags. Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_catch_all_4 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags. Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L. The American Association of Immunologists (AAI) 0022-1767 00221767 1550-6606 15506606 |
| shingle_title_1 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] |
| shingle_title_2 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] |
| shingle_title_3 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] |
| shingle_title_4 | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] |
| timestamp | 2025-06-30T23:34:30.739Z |
| titel | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] |
| titel_suche | Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION] |
| topic | WW-YZ |
| uid | ipn_articles_6242842 |