Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]

Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
The American Association of Immunologists (AAI)
Published 2018
Publication Date:
2018-04-24
Publisher:
The American Association of Immunologists (AAI)
Print ISSN:
0022-1767
Electronic ISSN:
1550-6606
Topics:
Medicine
Published by:
_version_ 1836398906788806656
autor Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
beschreibung Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags.
citation_standardnr 6242842
datenlieferant ipn_articles
feed_id 333
feed_publisher The American Association of Immunologists (AAI)
feed_publisher_url http://www.aai.org/
insertion_date 2018-04-24
journaleissn 1550-6606
journalissn 0022-1767
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Association of Immunologists (AAI)
quelle Journal of Immunology
relation http://www.jimmunol.org/cgi/content/short/200/9/3117?rss=1
search_space articles
shingle_author_1 Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
shingle_author_2 Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
shingle_author_3 Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
shingle_author_4 Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
shingle_catch_all_1 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags.
Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_2 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags.
Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_3 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags.
Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_4 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
Invariant NKT (iNKT) cells have been shown to help B cells in a cognate or noncognate manner; however, whether cognate iNKT cell help induces B cell memory responses remains controversial, and the underlying mechanisms are still unclear. In this study, we demonstrated that, in the absence of follicular helper T cells, cognate iNKT cell help could promote B cell memory responses in mice that were dependent on the formation of memory follicular helper iNKT (iNKT FH ) cells and their interactions with memory B cells in recall responses. Generation of memory iNKT FH cells required lipid Ag presentation by dendritic cells but not by B cells. Upon rechallenge, memory iNKT FH cells recognized lipid Ags presented by memory B cells, which recalled iNKT FH effector cells and elicited B cell memory responses. However, LPS, which promoted the synthesis of self-lipids, failed to elicit recall responses in the absence of exogenous lipid Ags.
Chen, Z., Zhu, S., Wang, L., Xie, D., Zhang, H., Li, X., Zheng, X., Du, Z., Li, J., Bai, L.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_title_1 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
shingle_title_2 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
shingle_title_3 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
shingle_title_4 Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
timestamp 2025-06-30T23:34:30.739Z
titel Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
titel_suche Memory Follicular Helper Invariant NKT Cells Recognize Lipid Antigens on Memory B Cells and Elicit Antibody Recall Responses [IMMUNE REGULATION]
topic WW-YZ
uid ipn_articles_6242842