Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]

Publication Date:
2018-04-24
Publisher:
The American Society for Microbiology (ASM)
Print ISSN:
0019-9567
Electronic ISSN:
1098-5522
Topics:
Medicine
Published by:
http://www.asm.org/
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autor Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
beschreibung Coccidiosis, caused by different species of Eimeria parasites, is an economically important disease of poultry and livestock worldwide. Here we report previously unknown alterations in the gut microbes and metabolism of BALB/c mice infected with Eimeria falciformis . Specifically, we observed a significant shift in the abundance of cecal bacteria and disrupted metabolism in parasitized animals. The relative abundances of Lachnospiraceae bacterium NK4A136, Ruminiclostridium , Alistipes , and Lactobacillus declined in response to E. falciformis infection, whereas Escherichia , Shigella , Helicobacter , Klebsiella , and Bacteroides were increased. Carbohydrate and amino acid metabolites in the serum samples of infected mice were significantly altered compared to naïve controls. Levels of amino acids, including asparagine, histidine, l -cysteine, tryptophan, lysine, glycine, serine, alanine, proline, ornithine, methionine, and valine, decreased on day 7 postinfection before returning to baseline on day 14. In addition, increased levels of indolelactate and mannitol and a reduced amount of oxalic acid indicated impaired carbon metabolism upon parasitic infection. These data demonstrate that intestinal coccidial infection perturbs the microbiota and disrupts carbon and nitrogen metabolism.
citation_standardnr 6242767
datenlieferant ipn_articles
feed_id 519
feed_publisher The American Society for Microbiology (ASM)
feed_publisher_url http://www.asm.org/
insertion_date 2018-04-24
journaleissn 1098-5522
journalissn 0019-9567
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Society for Microbiology (ASM)
quelle Infection and Immunity
relation http://iai.asm.org/cgi/content/short/86/5/e00073-18?rss=1
search_space articles
shingle_author_1 Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
shingle_author_2 Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
shingle_author_3 Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
shingle_author_4 Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
shingle_catch_all_1 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
Coccidiosis, caused by different species of Eimeria parasites, is an economically important disease of poultry and livestock worldwide. Here we report previously unknown alterations in the gut microbes and metabolism of BALB/c mice infected with Eimeria falciformis . Specifically, we observed a significant shift in the abundance of cecal bacteria and disrupted metabolism in parasitized animals. The relative abundances of Lachnospiraceae bacterium NK4A136, Ruminiclostridium , Alistipes , and Lactobacillus declined in response to E. falciformis infection, whereas Escherichia , Shigella , Helicobacter , Klebsiella , and Bacteroides were increased. Carbohydrate and amino acid metabolites in the serum samples of infected mice were significantly altered compared to naïve controls. Levels of amino acids, including asparagine, histidine, l -cysteine, tryptophan, lysine, glycine, serine, alanine, proline, ornithine, methionine, and valine, decreased on day 7 postinfection before returning to baseline on day 14. In addition, increased levels of indolelactate and mannitol and a reduced amount of oxalic acid indicated impaired carbon metabolism upon parasitic infection. These data demonstrate that intestinal coccidial infection perturbs the microbiota and disrupts carbon and nitrogen metabolism.
Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
The American Society for Microbiology (ASM)
0019-9567
00199567
1098-5522
10985522
shingle_catch_all_2 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
Coccidiosis, caused by different species of Eimeria parasites, is an economically important disease of poultry and livestock worldwide. Here we report previously unknown alterations in the gut microbes and metabolism of BALB/c mice infected with Eimeria falciformis . Specifically, we observed a significant shift in the abundance of cecal bacteria and disrupted metabolism in parasitized animals. The relative abundances of Lachnospiraceae bacterium NK4A136, Ruminiclostridium , Alistipes , and Lactobacillus declined in response to E. falciformis infection, whereas Escherichia , Shigella , Helicobacter , Klebsiella , and Bacteroides were increased. Carbohydrate and amino acid metabolites in the serum samples of infected mice were significantly altered compared to naïve controls. Levels of amino acids, including asparagine, histidine, l -cysteine, tryptophan, lysine, glycine, serine, alanine, proline, ornithine, methionine, and valine, decreased on day 7 postinfection before returning to baseline on day 14. In addition, increased levels of indolelactate and mannitol and a reduced amount of oxalic acid indicated impaired carbon metabolism upon parasitic infection. These data demonstrate that intestinal coccidial infection perturbs the microbiota and disrupts carbon and nitrogen metabolism.
Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
The American Society for Microbiology (ASM)
0019-9567
00199567
1098-5522
10985522
shingle_catch_all_3 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
Coccidiosis, caused by different species of Eimeria parasites, is an economically important disease of poultry and livestock worldwide. Here we report previously unknown alterations in the gut microbes and metabolism of BALB/c mice infected with Eimeria falciformis . Specifically, we observed a significant shift in the abundance of cecal bacteria and disrupted metabolism in parasitized animals. The relative abundances of Lachnospiraceae bacterium NK4A136, Ruminiclostridium , Alistipes , and Lactobacillus declined in response to E. falciformis infection, whereas Escherichia , Shigella , Helicobacter , Klebsiella , and Bacteroides were increased. Carbohydrate and amino acid metabolites in the serum samples of infected mice were significantly altered compared to naïve controls. Levels of amino acids, including asparagine, histidine, l -cysteine, tryptophan, lysine, glycine, serine, alanine, proline, ornithine, methionine, and valine, decreased on day 7 postinfection before returning to baseline on day 14. In addition, increased levels of indolelactate and mannitol and a reduced amount of oxalic acid indicated impaired carbon metabolism upon parasitic infection. These data demonstrate that intestinal coccidial infection perturbs the microbiota and disrupts carbon and nitrogen metabolism.
Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
The American Society for Microbiology (ASM)
0019-9567
00199567
1098-5522
10985522
shingle_catch_all_4 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
Coccidiosis, caused by different species of Eimeria parasites, is an economically important disease of poultry and livestock worldwide. Here we report previously unknown alterations in the gut microbes and metabolism of BALB/c mice infected with Eimeria falciformis . Specifically, we observed a significant shift in the abundance of cecal bacteria and disrupted metabolism in parasitized animals. The relative abundances of Lachnospiraceae bacterium NK4A136, Ruminiclostridium , Alistipes , and Lactobacillus declined in response to E. falciformis infection, whereas Escherichia , Shigella , Helicobacter , Klebsiella , and Bacteroides were increased. Carbohydrate and amino acid metabolites in the serum samples of infected mice were significantly altered compared to naïve controls. Levels of amino acids, including asparagine, histidine, l -cysteine, tryptophan, lysine, glycine, serine, alanine, proline, ornithine, methionine, and valine, decreased on day 7 postinfection before returning to baseline on day 14. In addition, increased levels of indolelactate and mannitol and a reduced amount of oxalic acid indicated impaired carbon metabolism upon parasitic infection. These data demonstrate that intestinal coccidial infection perturbs the microbiota and disrupts carbon and nitrogen metabolism.
Huang, G., Zhang, S., Zhou, C., Tang, X., Li, C., Wang, C., Tang, X., Suo, J., Jia, Y., El-Ashram, S., Yu, Z., Cai, J., Gupta, N., Suo, X., Liu, X.
The American Society for Microbiology (ASM)
0019-9567
00199567
1098-5522
10985522
shingle_title_1 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
shingle_title_2 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
shingle_title_3 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
shingle_title_4 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
timestamp 2025-06-30T23:34:30.739Z
titel Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
titel_suche Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice [Fungal and Parasitic Infections]
topic WW-YZ
uid ipn_articles_6242767