[ASAP] Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation

Brian T. O’Neill, Elizabeth M. Beck, Christopher R. Butler, Charles E. Nolan, Cathleen Gonzales, Lei Zhang, Shawn D. Doran, Kimberly Lapham, Leanne M. Buzon, Jason K. Dutra, Gabriela Barreiro, Xinjun Hou, Luis A. Martinez-Alsina, Bruce N. Rogers, Anabella Villalobos, John C. Murray, Kevin Ogilvie, Erik A. La; Chapelle, Cheng Chang, Lorraine F. Lanyon, Claire M. Steppan, Ashley Robshaw, Katherine Hales, Germaine G. Boucher, Karamjeet Pandher, Christopher Houle, Claude W. Ambroise, David Karanian, David Riddell, Kelly R. Bales, Michael A. Brodney
American Chemical Society (ACS)
Published 2018