Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]

Publication Date:
2018-04-13
Publisher:
American Heart Association (AHA)
Print ISSN:
0009-7330
Electronic ISSN:
1524-4571
Topics:
Medicine
Keywords:
Angiogenesis, Inflammation, Nephrology and Kidney, Vascular Biology, Hypertension
Published by:
http://www.americanheart.org/
_version_ 1836398889572237314
autor Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
beschreibung Rationale:Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown.Objective:We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation.Methods and Results:Mice with salt-sensitive hypertension or nitric oxide synthase inhibition–induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension.Conclusions:These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.
citation_standardnr 6232904
datenlieferant ipn_articles
feed_id 321
feed_publisher American Heart Association (AHA)
feed_publisher_url http://www.americanheart.org/
insertion_date 2018-04-13
journaleissn 1524-4571
journalissn 0009-7330
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher American Heart Association (AHA)
quelle Circulation Research
relation http://circres.ahajournals.org/content/122/8/1094.short?rss=1
schlagwort Angiogenesis, Inflammation, Nephrology and Kidney, Vascular Biology, Hypertension
search_space articles
shingle_author_1 Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
shingle_author_2 Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
shingle_author_3 Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
shingle_author_4 Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
shingle_catch_all_1 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
Angiogenesis, Inflammation, Nephrology and Kidney, Vascular Biology, Hypertension
Rationale:Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown.Objective:We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation.Methods and Results:Mice with salt-sensitive hypertension or nitric oxide synthase inhibition–induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension.Conclusions:These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.
Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
American Heart Association (AHA)
0009-7330
00097330
1524-4571
15244571
shingle_catch_all_2 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
Angiogenesis, Inflammation, Nephrology and Kidney, Vascular Biology, Hypertension
Rationale:Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown.Objective:We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation.Methods and Results:Mice with salt-sensitive hypertension or nitric oxide synthase inhibition–induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension.Conclusions:These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.
Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
American Heart Association (AHA)
0009-7330
00097330
1524-4571
15244571
shingle_catch_all_3 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
Angiogenesis, Inflammation, Nephrology and Kidney, Vascular Biology, Hypertension
Rationale:Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown.Objective:We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation.Methods and Results:Mice with salt-sensitive hypertension or nitric oxide synthase inhibition–induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension.Conclusions:These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.
Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
American Heart Association (AHA)
0009-7330
00097330
1524-4571
15244571
shingle_catch_all_4 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
Angiogenesis, Inflammation, Nephrology and Kidney, Vascular Biology, Hypertension
Rationale:Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown.Objective:We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation.Methods and Results:Mice with salt-sensitive hypertension or nitric oxide synthase inhibition–induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension.Conclusions:These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.
Catalina A. Lopez Gelston, Dakshnapriya Balasubbramanian, Gabriella R. Abouelkheir, Alexandra H. Lopez, Kayla R. Hudson, Eric R. Johnson, Mariappan Muthuchamy, Brett M. Mitchell, Joseph M. Rutkowski
American Heart Association (AHA)
0009-7330
00097330
1524-4571
15244571
shingle_title_1 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
shingle_title_2 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
shingle_title_3 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
shingle_title_4 Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
timestamp 2025-06-30T23:34:15.517Z
titel Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
titel_suche Enhancing Renal Lymphatic Expansion Prevents Hypertension in MiceNovelty and Significance [Integrative Physiology]
topic WW-YZ
uid ipn_articles_6232904