Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]

Publication Date:
2018-04-05
Publisher:
Genetics Society of America (GSA)
Print ISSN:
0016-6731
Topics:
Biology
Published by:
http://www.genetics-gsa.org/
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autor Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
beschreibung Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
citation_standardnr 6225904
datenlieferant ipn_articles
feed_id 2584
feed_publisher Genetics Society of America (GSA)
feed_publisher_url http://www.genetics-gsa.org/
insertion_date 2018-04-05
journalissn 0016-6731
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Genetics Society of America (GSA)
quelle Genetics
relation http://www.genetics.org/cgi/content/short/208/4/1657?rss=1
search_space articles
shingle_author_1 Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
shingle_author_2 Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
shingle_author_3 Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
shingle_author_4 Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
shingle_catch_all_1 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_catch_all_2 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_catch_all_3 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_catch_all_4 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
Dermatophytes include fungal species that infect humans, as well as those that also infect other animals or only grow in the environment. The dermatophyte species Trichophyton rubrum is a frequent cause of skin infection in immunocompetent individuals. While members of the T. rubrum species complex have been further categorized based on various morphologies, their population structure and ability to undergo sexual reproduction are not well understood. In this study, we analyze a large set of T. rubrum and T. interdigitale isolates to examine mating types, evidence of mating, and genetic variation. We find that nearly all isolates of T. rubrum are of a single mating type, and that incubation with T. rubrum "morphotype" megninii isolates of the other mating type failed to induce sexual development. While the region around the mating type locus is characterized by a higher frequency of SNPs compared to other genomic regions, we find that the population is remarkably clonal, with highly conserved gene content, low levels of variation, and little evidence of recombination. These results support a model of recent transition to asexual growth when this species specialized to growth on human hosts.
Persinoti, G. F., Martinez, D. A., Li, W., Do F;en, A., Billmyre, R. B., Averette, A., Goldberg, J. M., Shea, T., Young, S., Zeng, Q., Oliver, B. G., Barton, R., Metin, B., Hilmio F;lu-Polat, S., Ilkit, M., Graser, Y., Martinez-Rossi, N. M., White, T. C., Heitman, J., Cuomo, C. A.
Genetics Society of America (GSA)
0016-6731
00166731
shingle_title_1 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
shingle_title_2 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
shingle_title_3 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
shingle_title_4 Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
timestamp 2025-06-30T23:34:03.633Z
titel Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
titel_suche Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum [Genome and Systems Biology]
topic W
uid ipn_articles_6225904