Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
The American Society for Microbiology (ASM)
Published 2018
The American Society for Microbiology (ASM)
Published 2018
| Publication Date: |
2018-03-28
|
|---|---|
| Publisher: |
The American Society for Microbiology (ASM)
|
| Print ISSN: |
0066-4804
|
| Electronic ISSN: |
1098-6596
|
| Topics: |
Biology
Medicine
|
| Published by: |
| _version_ | 1836398866538168320 |
|---|---|
| autor | Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. |
| beschreibung | Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of 〉4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was 〉50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii . |
| citation_standardnr | 6218927 |
| datenlieferant | ipn_articles |
| feed_id | 515 |
| feed_publisher | The American Society for Microbiology (ASM) |
| feed_publisher_url | http://www.asm.org/ |
| insertion_date | 2018-03-28 |
| journaleissn | 1098-6596 |
| journalissn | 0066-4804 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Society for Microbiology (ASM) |
| quelle | Antimicrobial Agents and Chemotherapy |
| relation | http://aac.asm.org/cgi/content/short/62/4/e02585-17?rss=1 |
| search_space | articles |
| shingle_author_1 | Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. |
| shingle_author_2 | Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. |
| shingle_author_3 | Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. |
| shingle_author_4 | Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. |
| shingle_catch_all_1 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii . Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. The American Society for Microbiology (ASM) 0066-4804 00664804 1098-6596 10986596 |
| shingle_catch_all_2 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii . Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. The American Society for Microbiology (ASM) 0066-4804 00664804 1098-6596 10986596 |
| shingle_catch_all_3 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii . Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. The American Society for Microbiology (ASM) 0066-4804 00664804 1098-6596 10986596 |
| shingle_catch_all_4 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii . Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E. The American Society for Microbiology (ASM) 0066-4804 00664804 1098-6596 10986596 |
| shingle_title_1 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] |
| shingle_title_2 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] |
| shingle_title_3 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] |
| shingle_title_4 | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] |
| timestamp | 2025-06-30T23:33:52.711Z |
| titel | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] |
| titel_suche | Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics] |
| topic | W WW-YZ |
| uid | ipn_articles_6218927 |