Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]

Publication Date:
2018-03-28
Publisher:
The American Society for Microbiology (ASM)
Print ISSN:
0066-4804
Electronic ISSN:
1098-6596
Topics:
Biology
Medicine
Published by:
_version_ 1836398866538168320
autor Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
beschreibung Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of 〉4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was 〉50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii .
citation_standardnr 6218927
datenlieferant ipn_articles
feed_id 515
feed_publisher The American Society for Microbiology (ASM)
feed_publisher_url http://www.asm.org/
insertion_date 2018-03-28
journaleissn 1098-6596
journalissn 0066-4804
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Society for Microbiology (ASM)
quelle Antimicrobial Agents and Chemotherapy
relation http://aac.asm.org/cgi/content/short/62/4/e02585-17?rss=1
search_space articles
shingle_author_1 Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
shingle_author_2 Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
shingle_author_3 Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
shingle_author_4 Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
shingle_catch_all_1 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii .
Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
The American Society for Microbiology (ASM)
0066-4804
00664804
1098-6596
10986596
shingle_catch_all_2 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii .
Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
The American Society for Microbiology (ASM)
0066-4804
00664804
1098-6596
10986596
shingle_catch_all_3 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii .
Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
The American Society for Microbiology (ASM)
0066-4804
00664804
1098-6596
10986596
shingle_catch_all_4 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii . In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log 10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum ( C max )/MIC was 10 or higher. Based on these findings, we suggest that apramycin deserves further preclinical exploration as a repurposed therapeutic for multidrug-resistant Gram-negative pathogens, including A. baumannii .
Kang, A. D., Smith, K. P., Berg, A. H., Truelson, K. A., Eliopoulos, G. M., McCoy, C., Kirby, J. E.
The American Society for Microbiology (ASM)
0066-4804
00664804
1098-6596
10986596
shingle_title_1 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
shingle_title_2 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
shingle_title_3 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
shingle_title_4 Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
timestamp 2025-06-30T23:33:52.711Z
titel Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
titel_suche Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model [Experimental Therapeutics]
topic W
WW-YZ
uid ipn_articles_6218927