Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

Laura A. McAllister, Christopher R. Butler, Scot Mente, Steven V. O’Neil, Kari R. Fonseca, Justin R. Piro, Julie A. Cianfrogna, Timothy L. Foley, Adam M. Gilbert, Anthony R. Harris, Christopher J. Helal, Douglas S. Johnson, Justin I. Montgomery, Deane M. Nason, Stephen Noell, Jayvardhan Pandit, Bruce N. Rogers, Tarek A. Samad, Christopher L. Shaffer, Rafael G. da Silva, Daniel P. Uccello, Damien Webb and Michael A. Brodney
American Chemical Society (ACS)
Published 2018