Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine
| Publication Date: |
2018-03-14
|
|---|---|
| Publisher: |
Oxford University Press
|
| Print ISSN: |
0022-1899
|
| Electronic ISSN: |
1537-6613
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398846910922752 |
|---|---|
| autor | Levin M, Cai G, Lee K, et al. |
| beschreibung | We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. |
| citation_standardnr | 6206596 |
| datenlieferant | ipn_articles |
| feed_copyright | The Infectious Diseases Society of America (IDSA) |
| feed_copyright_url | http://www.idsociety.org/ |
| feed_id | 3041 |
| feed_publisher | Oxford University Press |
| feed_publisher_url | http://global.oup.com/ |
| insertion_date | 2018-03-14 |
| journaleissn | 1537-6613 |
| journalissn | 0022-1899 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | Oxford University Press |
| quelle | Journal of Infectious Diseases |
| relation | https://academic.oup.com/jid/article/217/7/1055/4835758?rss=1 |
| search_space | articles |
| shingle_author_1 | Levin M, Cai G, Lee K, et al. |
| shingle_author_2 | Levin M, Cai G, Lee K, et al. |
| shingle_author_3 | Levin M, Cai G, Lee K, et al. |
| shingle_author_4 | Levin M, Cai G, Lee K, et al. |
| shingle_catch_all_1 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. Levin M, Cai G, Lee K, et al. Oxford University Press 0022-1899 00221899 1537-6613 15376613 |
| shingle_catch_all_2 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. Levin M, Cai G, Lee K, et al. Oxford University Press 0022-1899 00221899 1537-6613 15376613 |
| shingle_catch_all_3 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. Levin M, Cai G, Lee K, et al. Oxford University Press 0022-1899 00221899 1537-6613 15376613 |
| shingle_catch_all_4 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Teff progressively increased in direct-PCR-positive vaccinees up to day 30, but Tmem did not. Conversely, Tmem, but not Teff, increased in direct-PCR-negative vaccinees on day 7. The kinetics of these immune responses and VZV DNAemia suggested that direct-PCR sample positive represented viremia. Levin M, Cai G, Lee K, et al. Oxford University Press 0022-1899 00221899 1537-6613 15376613 |
| shingle_title_1 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine |
| shingle_title_2 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine |
| shingle_title_3 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine |
| shingle_title_4 | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine |
| timestamp | 2025-06-30T23:33:33.388Z |
| titel | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine |
| titel_suche | Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine |
| topic | WW-YZ |
| uid | ipn_articles_6206596 |