Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans

Publication Date:
2018-03-06
Publisher:
The Society of Nuclear Medicine (SNM)
Print ISSN:
0022-3123
Topics:
Medicine
Published by:
http://www.snm.org/
_version_ 1836398825749610496
autor Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
beschreibung Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilizes glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by the current standard method of assessing BAT—PET/CT—as it requires exposure to high doses of ionizing radiation. Infrared thermography (IRT) is a potential noninvasive, safe alternative, although direct corroboration with PET/CT has not been established. Methods: IRT and 18 F-FDG PET/CT data from 8 healthy men subjected to water-jacket cooling were directly compared. Thermal images were geometrically transformed to overlay PET/CT-derived maximum intensity projection (MIP) images from each subject, and the areas with the most intense temperature and glucose uptake within the supraclavicular regions were compared. Relationships between supraclavicular temperatures (T SCR ) from IRT and the metabolic rate of glucose uptake (MR(gluc)) from PET/CT were determined. Results: Glucose uptake on MR(gluc) MIP was found to correlate positively with a change in T SCR relative to a reference region ( r 2 = 0.721; P = 0.008). Spatial overlap between areas of maximal MR(gluc) MIP and maximal T SCR was 29.5% ± 5.1%. Prolonged cooling, for 60 min, was associated with a further T SCR rise, compared with cooling for 10 min. Conclusion: The supraclavicular hotspot identified on IRT closely corresponded to the area of maximal uptake on PET/CT-derived MR(gluc) MIP images. Greater increases in relative T SCR were associated with raised glucose uptake. IRT should now be considered a suitable method for measuring BAT activation, especially in populations for whom PET/CT is not feasible, practical, or repeatable.
citation_standardnr 6190029
datenlieferant ipn_articles
feed_id 9585
feed_publisher The Society of Nuclear Medicine (SNM)
feed_publisher_url http://www.snm.org/
insertion_date 2018-03-06
journalissn 0022-3123
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The Society of Nuclear Medicine (SNM)
quelle Journal of Nuclear Medicine
relation http://jnm.snmjournals.org/cgi/content/short/59/3/516?rss=1
search_space articles
shingle_author_1 Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
shingle_author_2 Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
shingle_author_3 Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
shingle_author_4 Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
shingle_catch_all_1 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilizes glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by the current standard method of assessing BAT—PET/CT—as it requires exposure to high doses of ionizing radiation. Infrared thermography (IRT) is a potential noninvasive, safe alternative, although direct corroboration with PET/CT has not been established. Methods: IRT and 18 F-FDG PET/CT data from 8 healthy men subjected to water-jacket cooling were directly compared. Thermal images were geometrically transformed to overlay PET/CT-derived maximum intensity projection (MIP) images from each subject, and the areas with the most intense temperature and glucose uptake within the supraclavicular regions were compared. Relationships between supraclavicular temperatures (T SCR ) from IRT and the metabolic rate of glucose uptake (MR(gluc)) from PET/CT were determined. Results: Glucose uptake on MR(gluc) MIP was found to correlate positively with a change in T SCR relative to a reference region ( r 2 = 0.721; P = 0.008). Spatial overlap between areas of maximal MR(gluc) MIP and maximal T SCR was 29.5% ± 5.1%. Prolonged cooling, for 60 min, was associated with a further T SCR rise, compared with cooling for 10 min. Conclusion: The supraclavicular hotspot identified on IRT closely corresponded to the area of maximal uptake on PET/CT-derived MR(gluc) MIP images. Greater increases in relative T SCR were associated with raised glucose uptake. IRT should now be considered a suitable method for measuring BAT activation, especially in populations for whom PET/CT is not feasible, practical, or repeatable.
Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
The Society of Nuclear Medicine (SNM)
0022-3123
00223123
shingle_catch_all_2 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilizes glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by the current standard method of assessing BAT—PET/CT—as it requires exposure to high doses of ionizing radiation. Infrared thermography (IRT) is a potential noninvasive, safe alternative, although direct corroboration with PET/CT has not been established. Methods: IRT and 18 F-FDG PET/CT data from 8 healthy men subjected to water-jacket cooling were directly compared. Thermal images were geometrically transformed to overlay PET/CT-derived maximum intensity projection (MIP) images from each subject, and the areas with the most intense temperature and glucose uptake within the supraclavicular regions were compared. Relationships between supraclavicular temperatures (T SCR ) from IRT and the metabolic rate of glucose uptake (MR(gluc)) from PET/CT were determined. Results: Glucose uptake on MR(gluc) MIP was found to correlate positively with a change in T SCR relative to a reference region ( r 2 = 0.721; P = 0.008). Spatial overlap between areas of maximal MR(gluc) MIP and maximal T SCR was 29.5% ± 5.1%. Prolonged cooling, for 60 min, was associated with a further T SCR rise, compared with cooling for 10 min. Conclusion: The supraclavicular hotspot identified on IRT closely corresponded to the area of maximal uptake on PET/CT-derived MR(gluc) MIP images. Greater increases in relative T SCR were associated with raised glucose uptake. IRT should now be considered a suitable method for measuring BAT activation, especially in populations for whom PET/CT is not feasible, practical, or repeatable.
Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
The Society of Nuclear Medicine (SNM)
0022-3123
00223123
shingle_catch_all_3 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilizes glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by the current standard method of assessing BAT—PET/CT—as it requires exposure to high doses of ionizing radiation. Infrared thermography (IRT) is a potential noninvasive, safe alternative, although direct corroboration with PET/CT has not been established. Methods: IRT and 18 F-FDG PET/CT data from 8 healthy men subjected to water-jacket cooling were directly compared. Thermal images were geometrically transformed to overlay PET/CT-derived maximum intensity projection (MIP) images from each subject, and the areas with the most intense temperature and glucose uptake within the supraclavicular regions were compared. Relationships between supraclavicular temperatures (T SCR ) from IRT and the metabolic rate of glucose uptake (MR(gluc)) from PET/CT were determined. Results: Glucose uptake on MR(gluc) MIP was found to correlate positively with a change in T SCR relative to a reference region ( r 2 = 0.721; P = 0.008). Spatial overlap between areas of maximal MR(gluc) MIP and maximal T SCR was 29.5% ± 5.1%. Prolonged cooling, for 60 min, was associated with a further T SCR rise, compared with cooling for 10 min. Conclusion: The supraclavicular hotspot identified on IRT closely corresponded to the area of maximal uptake on PET/CT-derived MR(gluc) MIP images. Greater increases in relative T SCR were associated with raised glucose uptake. IRT should now be considered a suitable method for measuring BAT activation, especially in populations for whom PET/CT is not feasible, practical, or repeatable.
Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
The Society of Nuclear Medicine (SNM)
0022-3123
00223123
shingle_catch_all_4 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
Obesity and its metabolic consequences are a major cause of morbidity and mortality. Brown adipose tissue (BAT) utilizes glucose and free fatty acids to produce heat, thereby increasing energy expenditure. Effective evaluation of human BAT stimulators is constrained by the current standard method of assessing BAT—PET/CT—as it requires exposure to high doses of ionizing radiation. Infrared thermography (IRT) is a potential noninvasive, safe alternative, although direct corroboration with PET/CT has not been established. Methods: IRT and 18 F-FDG PET/CT data from 8 healthy men subjected to water-jacket cooling were directly compared. Thermal images were geometrically transformed to overlay PET/CT-derived maximum intensity projection (MIP) images from each subject, and the areas with the most intense temperature and glucose uptake within the supraclavicular regions were compared. Relationships between supraclavicular temperatures (T SCR ) from IRT and the metabolic rate of glucose uptake (MR(gluc)) from PET/CT were determined. Results: Glucose uptake on MR(gluc) MIP was found to correlate positively with a change in T SCR relative to a reference region ( r 2 = 0.721; P = 0.008). Spatial overlap between areas of maximal MR(gluc) MIP and maximal T SCR was 29.5% ± 5.1%. Prolonged cooling, for 60 min, was associated with a further T SCR rise, compared with cooling for 10 min. Conclusion: The supraclavicular hotspot identified on IRT closely corresponded to the area of maximal uptake on PET/CT-derived MR(gluc) MIP images. Greater increases in relative T SCR were associated with raised glucose uptake. IRT should now be considered a suitable method for measuring BAT activation, especially in populations for whom PET/CT is not feasible, practical, or repeatable.
Law, J., Morris, D. E., Izzi-Engbeaya, C., Salem, V., Coello, C., Robinson, L., Jayasinghe, M., Scott, R., Gunn, R., Rabiner, E., Tan, T., Dhillo, W. S., Bloom, S., Budge, H., Symonds, M. E.
The Society of Nuclear Medicine (SNM)
0022-3123
00223123
shingle_title_1 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
shingle_title_2 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
shingle_title_3 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
shingle_title_4 Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
timestamp 2025-06-30T23:33:14.739Z
titel Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
titel_suche Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans
topic WW-YZ
uid ipn_articles_6190029