Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women

Publication Date:
2018-03-06
Publisher:
Wiley-Blackwell
Print ISSN:
0020-7136
Electronic ISSN:
1097-0215
Topics:
Biology
Medicine
Published by:
http://www.wiley.com/wiley-blackwell
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autor Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
beschreibung Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes, and homeostasis model-insulin resistance (HOMA-IR – a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-〈25.0, 25.0-〈30.0, and ≥30.0 kg/m 2 ) and presence of the metabolic syndrome into 6 phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Neither BMI nor presence of the metabolic syndrome was associated with risk of colorectal cancer, whereas waist circumference showed a robust positive association. Relative to the MHNW phenotype, the MUNW phenotype was associated with increased risk, whereas no other phenotype showed an association. Furthermore, HOMA-IR was not associated with increased risk. Overall, our results do not support a direct role of metabolic dysregulation in the development of colorectal cancer; however, they do suggest that higher waist circumference is a risk factor, possibly reflecting the effects of increased levels of cytokines and hormones in visceral abdominal fat on colorectal carcinogenesis. This article is protected by copyright. All rights reserved.
citation_standardnr 6187767
datenlieferant ipn_articles
feed_id 1959
feed_publisher Wiley-Blackwell
feed_publisher_url http://www.wiley.com/wiley-blackwell
insertion_date 2018-03-06
journaleissn 1097-0215
journalissn 0020-7136
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Wiley-Blackwell
quelle International Journal of Cancer
relation http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fijc.31345
search_space articles
shingle_author_1 Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
shingle_author_2 Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
shingle_author_3 Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
shingle_author_4 Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
shingle_catch_all_1 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes, and homeostasis model-insulin resistance (HOMA-IR – a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-<25.0, 25.0-<30.0, and ≥30.0 kg/m 2 ) and presence of the metabolic syndrome into 6 phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Neither BMI nor presence of the metabolic syndrome was associated with risk of colorectal cancer, whereas waist circumference showed a robust positive association. Relative to the MHNW phenotype, the MUNW phenotype was associated with increased risk, whereas no other phenotype showed an association. Furthermore, HOMA-IR was not associated with increased risk. Overall, our results do not support a direct role of metabolic dysregulation in the development of colorectal cancer; however, they do suggest that higher waist circumference is a risk factor, possibly reflecting the effects of increased levels of cytokines and hormones in visceral abdominal fat on colorectal carcinogenesis. This article is protected by copyright. All rights reserved.
Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
Wiley-Blackwell
0020-7136
00207136
1097-0215
10970215
shingle_catch_all_2 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes, and homeostasis model-insulin resistance (HOMA-IR – a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-<25.0, 25.0-<30.0, and ≥30.0 kg/m 2 ) and presence of the metabolic syndrome into 6 phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Neither BMI nor presence of the metabolic syndrome was associated with risk of colorectal cancer, whereas waist circumference showed a robust positive association. Relative to the MHNW phenotype, the MUNW phenotype was associated with increased risk, whereas no other phenotype showed an association. Furthermore, HOMA-IR was not associated with increased risk. Overall, our results do not support a direct role of metabolic dysregulation in the development of colorectal cancer; however, they do suggest that higher waist circumference is a risk factor, possibly reflecting the effects of increased levels of cytokines and hormones in visceral abdominal fat on colorectal carcinogenesis. This article is protected by copyright. All rights reserved.
Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
Wiley-Blackwell
0020-7136
00207136
1097-0215
10970215
shingle_catch_all_3 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes, and homeostasis model-insulin resistance (HOMA-IR – a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-<25.0, 25.0-<30.0, and ≥30.0 kg/m 2 ) and presence of the metabolic syndrome into 6 phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Neither BMI nor presence of the metabolic syndrome was associated with risk of colorectal cancer, whereas waist circumference showed a robust positive association. Relative to the MHNW phenotype, the MUNW phenotype was associated with increased risk, whereas no other phenotype showed an association. Furthermore, HOMA-IR was not associated with increased risk. Overall, our results do not support a direct role of metabolic dysregulation in the development of colorectal cancer; however, they do suggest that higher waist circumference is a risk factor, possibly reflecting the effects of increased levels of cytokines and hormones in visceral abdominal fat on colorectal carcinogenesis. This article is protected by copyright. All rights reserved.
Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
Wiley-Blackwell
0020-7136
00207136
1097-0215
10970215
shingle_catch_all_4 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes, and homeostasis model-insulin resistance (HOMA-IR – a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-<25.0, 25.0-<30.0, and ≥30.0 kg/m 2 ) and presence of the metabolic syndrome into 6 phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). Neither BMI nor presence of the metabolic syndrome was associated with risk of colorectal cancer, whereas waist circumference showed a robust positive association. Relative to the MHNW phenotype, the MUNW phenotype was associated with increased risk, whereas no other phenotype showed an association. Furthermore, HOMA-IR was not associated with increased risk. Overall, our results do not support a direct role of metabolic dysregulation in the development of colorectal cancer; however, they do suggest that higher waist circumference is a risk factor, possibly reflecting the effects of increased levels of cytokines and hormones in visceral abdominal fat on colorectal carcinogenesis. This article is protected by copyright. All rights reserved.
Geoffrey C. Kabat, Mimi Y. Kim, Marcia Stefanick, Gloria Y.F. Ho, Dorothy S. Lane, Andrew O. Odegaard, Michael S. Simon, Jennifer W. Bea, Juhua Luo, Sylvia Wassertheil-Smoller, Thomas E. Rohan
Wiley-Blackwell
0020-7136
00207136
1097-0215
10970215
shingle_title_1 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
shingle_title_2 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
shingle_title_3 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
shingle_title_4 Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
timestamp 2025-07-31T23:42:47.465Z
titel Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
titel_suche Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women
topic W
WW-YZ
uid ipn_articles_6187767