Precancer in ulcerative colitis: the role of the field effect and its clinical implications
| Publication Date: |
2018-03-06
|
|---|---|
| Publisher: |
Oxford University Press
|
| Print ISSN: |
0143-3334
|
| Electronic ISSN: |
1460-2180
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398817647263745 |
|---|---|
| autor | Baker K, Salk J, Brentnall T, et al. |
| beschreibung | Cumulative evidence indicates that a significant proportion of cancer evolution may occur before the development of histological abnormalities. While recent improvements in DNA sequencing technology have begun to reveal the presence of these early preneoplastic clones, the concept of ‘premalignant field’ was already introduced by Slaughter more than half a century ago. Also referred to as ‘field effect’, ‘field defect’ or ‘field cancerization’, these terms describe the phenomenon by which molecular alterations develop in normal-appearing tissue and expand to form premalignant patches with the potential to progress to dysplasia and cancer. Field effects have been well-characterized in ulcerative colitis, an inflammatory bowel disease that increases the risk of colorectal cancer. The study of the molecular alterations that define these fields is informative of mechanisms of tumor initiation and progression and has provided potential targets for early cancer detection. Herein, we summarize the current knowledge about the molecular alterations that comprise the field effect in ulcerative colitis and the clinical utility of these fields for cancer screening and prevention. |
| citation_standardnr | 6181566 |
| datenlieferant | ipn_articles |
| feed_id | 2588 |
| feed_publisher | Oxford University Press |
| feed_publisher_url | http://global.oup.com/ |
| insertion_date | 2018-03-06 |
| journaleissn | 1460-2180 |
| journalissn | 0143-3334 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | Oxford University Press |
| quelle | Carcinogenesis |
| relation | https://academic.oup.com/carcin/article/39/1/11/4566276?rss=1 |
| search_space | articles |
| shingle_author_1 | Baker K, Salk J, Brentnall T, et al. |
| shingle_author_2 | Baker K, Salk J, Brentnall T, et al. |
| shingle_author_3 | Baker K, Salk J, Brentnall T, et al. |
| shingle_author_4 | Baker K, Salk J, Brentnall T, et al. |
| shingle_catch_all_1 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications Cumulative evidence indicates that a significant proportion of cancer evolution may occur before the development of histological abnormalities. While recent improvements in DNA sequencing technology have begun to reveal the presence of these early preneoplastic clones, the concept of ‘premalignant field’ was already introduced by Slaughter more than half a century ago. Also referred to as ‘field effect’, ‘field defect’ or ‘field cancerization’, these terms describe the phenomenon by which molecular alterations develop in normal-appearing tissue and expand to form premalignant patches with the potential to progress to dysplasia and cancer. Field effects have been well-characterized in ulcerative colitis, an inflammatory bowel disease that increases the risk of colorectal cancer. The study of the molecular alterations that define these fields is informative of mechanisms of tumor initiation and progression and has provided potential targets for early cancer detection. Herein, we summarize the current knowledge about the molecular alterations that comprise the field effect in ulcerative colitis and the clinical utility of these fields for cancer screening and prevention. Baker K, Salk J, Brentnall T, et al. Oxford University Press 0143-3334 01433334 1460-2180 14602180 |
| shingle_catch_all_2 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications Cumulative evidence indicates that a significant proportion of cancer evolution may occur before the development of histological abnormalities. While recent improvements in DNA sequencing technology have begun to reveal the presence of these early preneoplastic clones, the concept of ‘premalignant field’ was already introduced by Slaughter more than half a century ago. Also referred to as ‘field effect’, ‘field defect’ or ‘field cancerization’, these terms describe the phenomenon by which molecular alterations develop in normal-appearing tissue and expand to form premalignant patches with the potential to progress to dysplasia and cancer. Field effects have been well-characterized in ulcerative colitis, an inflammatory bowel disease that increases the risk of colorectal cancer. The study of the molecular alterations that define these fields is informative of mechanisms of tumor initiation and progression and has provided potential targets for early cancer detection. Herein, we summarize the current knowledge about the molecular alterations that comprise the field effect in ulcerative colitis and the clinical utility of these fields for cancer screening and prevention. Baker K, Salk J, Brentnall T, et al. Oxford University Press 0143-3334 01433334 1460-2180 14602180 |
| shingle_catch_all_3 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications Cumulative evidence indicates that a significant proportion of cancer evolution may occur before the development of histological abnormalities. While recent improvements in DNA sequencing technology have begun to reveal the presence of these early preneoplastic clones, the concept of ‘premalignant field’ was already introduced by Slaughter more than half a century ago. Also referred to as ‘field effect’, ‘field defect’ or ‘field cancerization’, these terms describe the phenomenon by which molecular alterations develop in normal-appearing tissue and expand to form premalignant patches with the potential to progress to dysplasia and cancer. Field effects have been well-characterized in ulcerative colitis, an inflammatory bowel disease that increases the risk of colorectal cancer. The study of the molecular alterations that define these fields is informative of mechanisms of tumor initiation and progression and has provided potential targets for early cancer detection. Herein, we summarize the current knowledge about the molecular alterations that comprise the field effect in ulcerative colitis and the clinical utility of these fields for cancer screening and prevention. Baker K, Salk J, Brentnall T, et al. Oxford University Press 0143-3334 01433334 1460-2180 14602180 |
| shingle_catch_all_4 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications Cumulative evidence indicates that a significant proportion of cancer evolution may occur before the development of histological abnormalities. While recent improvements in DNA sequencing technology have begun to reveal the presence of these early preneoplastic clones, the concept of ‘premalignant field’ was already introduced by Slaughter more than half a century ago. Also referred to as ‘field effect’, ‘field defect’ or ‘field cancerization’, these terms describe the phenomenon by which molecular alterations develop in normal-appearing tissue and expand to form premalignant patches with the potential to progress to dysplasia and cancer. Field effects have been well-characterized in ulcerative colitis, an inflammatory bowel disease that increases the risk of colorectal cancer. The study of the molecular alterations that define these fields is informative of mechanisms of tumor initiation and progression and has provided potential targets for early cancer detection. Herein, we summarize the current knowledge about the molecular alterations that comprise the field effect in ulcerative colitis and the clinical utility of these fields for cancer screening and prevention. Baker K, Salk J, Brentnall T, et al. Oxford University Press 0143-3334 01433334 1460-2180 14602180 |
| shingle_title_1 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications |
| shingle_title_2 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications |
| shingle_title_3 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications |
| shingle_title_4 | Precancer in ulcerative colitis: the role of the field effect and its clinical implications |
| timestamp | 2025-06-30T23:33:06.898Z |
| titel | Precancer in ulcerative colitis: the role of the field effect and its clinical implications |
| titel_suche | Precancer in ulcerative colitis: the role of the field effect and its clinical implications |
| topic | WW-YZ |
| uid | ipn_articles_6181566 |