Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts
Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q.
American Association for the Advancement of Science (AAAS)
Published 2018
American Association for the Advancement of Science (AAAS)
Published 2018
| Publication Date: |
2018-02-16
|
|---|---|
| Publisher: |
American Association for the Advancement of Science (AAAS)
|
| Print ISSN: |
0036-8075
|
| Electronic ISSN: |
1095-9203
|
| Topics: |
Biology
Chemistry and Pharmacology
Geosciences
Computer Science
Medicine
Natural Sciences in General
Physics
|
| Keywords: |
Chemistry, Online Only
|
| Published by: |
| _version_ | 1836398798183596033 |
|---|---|
| autor | Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. |
| beschreibung | Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C–H bonds to new functionalities (such as C–C, C–N, and C–O bonds) has garnered much attention by the synthetic chemistry community. The utility of C–H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C–H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp 3 )–H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp 3 )–H bonds and stereomodels for asymmetric metalation of prochiral C–H bonds by these catalysts. |
| citation_standardnr | 6166972 |
| datenlieferant | ipn_articles |
| feed_id | 25 |
| feed_publisher | American Association for the Advancement of Science (AAAS) |
| feed_publisher_url | http://www.aaas.org/ |
| insertion_date | 2018-02-16 |
| journaleissn | 1095-9203 |
| journalissn | 0036-8075 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | American Association for the Advancement of Science (AAAS) |
| quelle | Science |
| relation | http://science.sciencemag.org/cgi/content/short/359/6377/eaao4798?rss=1 |
| schlagwort | Chemistry, Online Only |
| search_space | articles |
| shingle_author_1 | Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. |
| shingle_author_2 | Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. |
| shingle_author_3 | Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. |
| shingle_author_4 | Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. |
| shingle_catch_all_1 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts Chemistry, Online Only Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C–H bonds to new functionalities (such as C–C, C–N, and C–O bonds) has garnered much attention by the synthetic chemistry community. The utility of C–H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C–H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp 3 )–H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp 3 )–H bonds and stereomodels for asymmetric metalation of prochiral C–H bonds by these catalysts. Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_2 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts Chemistry, Online Only Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C–H bonds to new functionalities (such as C–C, C–N, and C–O bonds) has garnered much attention by the synthetic chemistry community. The utility of C–H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C–H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp 3 )–H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp 3 )–H bonds and stereomodels for asymmetric metalation of prochiral C–H bonds by these catalysts. Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_3 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts Chemistry, Online Only Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C–H bonds to new functionalities (such as C–C, C–N, and C–O bonds) has garnered much attention by the synthetic chemistry community. The utility of C–H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C–H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp 3 )–H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp 3 )–H bonds and stereomodels for asymmetric metalation of prochiral C–H bonds by these catalysts. Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_catch_all_4 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts Chemistry, Online Only Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C–H bonds to new functionalities (such as C–C, C–N, and C–O bonds) has garnered much attention by the synthetic chemistry community. The utility of C–H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C–H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp 3 )–H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp 3 )–H bonds and stereomodels for asymmetric metalation of prochiral C–H bonds by these catalysts. Saint-Denis, T. G., Zhu, R.-Y., Chen, G., Wu, Q.-F., Yu, J.-Q. American Association for the Advancement of Science (AAAS) 0036-8075 00368075 1095-9203 10959203 |
| shingle_title_1 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts |
| shingle_title_2 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts |
| shingle_title_3 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts |
| shingle_title_4 | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts |
| timestamp | 2025-06-30T23:32:48.390Z |
| titel | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts |
| titel_suche | Enantioselective C(sp3)-H bond activation by chiral transition metal catalysts |
| topic | W V TE-TZ SQ-SU WW-YZ TA-TD U |
| uid | ipn_articles_6166972 |