Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]

Publication Date:
2018-02-10
Publisher:
The American Association of Immunologists (AAI)
Print ISSN:
0022-1767
Electronic ISSN:
1550-6606
Topics:
Medicine
Published by:
http://www.aai.org/
_version_ 1836398787375923201
autor Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
beschreibung The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this study, we show that posttranslational modifications of E4bp4 by either SUMOylation or phosphorylation have profound effects on both E4bp4 function and NK cell development. We examined the activity of E4bp4 mutants lacking posttranslational modifications and found that Notch1 was a novel E4bp4 target gene. We observed that abrogation of Notch signaling impeded NK cell production and the total lack of NK cell development from E4bp4 –/– progenitors was completely rescued by short exposure to Notch peptide ligands. This work reveals both novel mechanisms in NK cell development by a transcriptional network including E4bp4 with Notch, and that E4bp4 is a central hub to process extrinsic stimuli.
citation_standardnr 6161254
datenlieferant ipn_articles
feed_id 333
feed_publisher The American Association of Immunologists (AAI)
feed_publisher_url http://www.aai.org/
insertion_date 2018-02-10
journaleissn 1550-6606
journalissn 0022-1767
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher The American Association of Immunologists (AAI)
quelle Journal of Immunology
relation http://www.jimmunol.org/cgi/content/short/200/4/1370?rss=1
search_space articles
shingle_author_1 Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
shingle_author_2 Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
shingle_author_3 Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
shingle_author_4 Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
shingle_catch_all_1 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this study, we show that posttranslational modifications of E4bp4 by either SUMOylation or phosphorylation have profound effects on both E4bp4 function and NK cell development. We examined the activity of E4bp4 mutants lacking posttranslational modifications and found that Notch1 was a novel E4bp4 target gene. We observed that abrogation of Notch signaling impeded NK cell production and the total lack of NK cell development from E4bp4 –/– progenitors was completely rescued by short exposure to Notch peptide ligands. This work reveals both novel mechanisms in NK cell development by a transcriptional network including E4bp4 with Notch, and that E4bp4 is a central hub to process extrinsic stimuli.
Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_2 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this study, we show that posttranslational modifications of E4bp4 by either SUMOylation or phosphorylation have profound effects on both E4bp4 function and NK cell development. We examined the activity of E4bp4 mutants lacking posttranslational modifications and found that Notch1 was a novel E4bp4 target gene. We observed that abrogation of Notch signaling impeded NK cell production and the total lack of NK cell development from E4bp4 –/– progenitors was completely rescued by short exposure to Notch peptide ligands. This work reveals both novel mechanisms in NK cell development by a transcriptional network including E4bp4 with Notch, and that E4bp4 is a central hub to process extrinsic stimuli.
Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_3 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this study, we show that posttranslational modifications of E4bp4 by either SUMOylation or phosphorylation have profound effects on both E4bp4 function and NK cell development. We examined the activity of E4bp4 mutants lacking posttranslational modifications and found that Notch1 was a novel E4bp4 target gene. We observed that abrogation of Notch signaling impeded NK cell production and the total lack of NK cell development from E4bp4 –/– progenitors was completely rescued by short exposure to Notch peptide ligands. This work reveals both novel mechanisms in NK cell development by a transcriptional network including E4bp4 with Notch, and that E4bp4 is a central hub to process extrinsic stimuli.
Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_catch_all_4 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
The transcription factor E4bp4/Nfil3 has been shown to have a critical role in the development of all innate lymphoid cell types including NK cells. In this study, we show that posttranslational modifications of E4bp4 by either SUMOylation or phosphorylation have profound effects on both E4bp4 function and NK cell development. We examined the activity of E4bp4 mutants lacking posttranslational modifications and found that Notch1 was a novel E4bp4 target gene. We observed that abrogation of Notch signaling impeded NK cell production and the total lack of NK cell development from E4bp4 –/– progenitors was completely rescued by short exposure to Notch peptide ligands. This work reveals both novel mechanisms in NK cell development by a transcriptional network including E4bp4 with Notch, and that E4bp4 is a central hub to process extrinsic stimuli.
Kostrzewski, T., Borg, A. J., Meng, Y., Filipovic, I., Male, V., Wack, A., Di; Maggio, P. A., Brady, H. J. M.
The American Association of Immunologists (AAI)
0022-1767
00221767
1550-6606
15506606
shingle_title_1 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
shingle_title_2 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
shingle_title_3 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
shingle_title_4 Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
timestamp 2025-06-30T23:32:38.167Z
titel Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
titel_suche Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development [IMMUNE SYSTEM DEVELOPMENT]
topic WW-YZ
uid ipn_articles_6161254