{gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury

Publication Date:
2018-02-10
Publisher:
Rockefeller University Press
Print ISSN:
0022-1007
Electronic ISSN:
1540-9538
Topics:
Medicine
Keywords:
Neuroinflammation, Neuroscience
Published by:
http://www.rupress.org/
_version_ 1836398787003678720
autor Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
beschreibung Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in T cells ( TCR –/– ) showed improved functional recovery after SCI. T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V4 subtype and express the inflammatory cytokine IFN-. Inactivating IFN- signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V4 antibodies has a beneficial effect, similar to that obtained with anti–TNF-α. In SCI patients, T cells are detected in the CSF, and most of them are IFN- positive. In conclusion, manipulation of T cell functions may be a potential approach for future SCI treatment.
citation_standardnr 6161222
datenlieferant ipn_articles
feed_id 96
feed_publisher Rockefeller University Press
feed_publisher_url http://www.rupress.org/
insertion_date 2018-02-10
journaleissn 1540-9538
journalissn 0022-1007
publikationsjahr_anzeige 2018
publikationsjahr_facette 2018
publikationsjahr_intervall 7984:2015-2019
publikationsjahr_sort 2018
publisher Rockefeller University Press
quelle Journal of Experimental Medicine
relation http://jem.rupress.org/cgi/content/short/215/2/521?rss=1
schlagwort Neuroinflammation, Neuroscience
search_space articles
shingle_author_1 Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
shingle_author_2 Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
shingle_author_3 Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
shingle_author_4 Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
shingle_catch_all_1 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
Neuroinflammation, Neuroscience
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in T cells ( TCR –/– ) showed improved functional recovery after SCI. T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V4 subtype and express the inflammatory cytokine IFN-. Inactivating IFN- signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V4 antibodies has a beneficial effect, similar to that obtained with anti–TNF-α. In SCI patients, T cells are detected in the CSF, and most of them are IFN- positive. In conclusion, manipulation of T cell functions may be a potential approach for future SCI treatment.
Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_catch_all_2 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
Neuroinflammation, Neuroscience
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in T cells ( TCR –/– ) showed improved functional recovery after SCI. T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V4 subtype and express the inflammatory cytokine IFN-. Inactivating IFN- signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V4 antibodies has a beneficial effect, similar to that obtained with anti–TNF-α. In SCI patients, T cells are detected in the CSF, and most of them are IFN- positive. In conclusion, manipulation of T cell functions may be a potential approach for future SCI treatment.
Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_catch_all_3 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
Neuroinflammation, Neuroscience
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in T cells ( TCR –/– ) showed improved functional recovery after SCI. T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V4 subtype and express the inflammatory cytokine IFN-. Inactivating IFN- signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V4 antibodies has a beneficial effect, similar to that obtained with anti–TNF-α. In SCI patients, T cells are detected in the CSF, and most of them are IFN- positive. In conclusion, manipulation of T cell functions may be a potential approach for future SCI treatment.
Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_catch_all_4 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
Neuroinflammation, Neuroscience
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI). T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in T cells ( TCR –/– ) showed improved functional recovery after SCI. T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V4 subtype and express the inflammatory cytokine IFN-. Inactivating IFN- signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V4 antibodies has a beneficial effect, similar to that obtained with anti–TNF-α. In SCI patients, T cells are detected in the CSF, and most of them are IFN- positive. In conclusion, manipulation of T cell functions may be a potential approach for future SCI treatment.
Sun, G., Yang, S., Cao, G., Wang, Q., Hao, J., Wen, Q., Li, Z., So, K.-F., Liu, Z., Zhou, S., Zhao, Y., Yang, H., Zhou, L., Yin, Z.
Rockefeller University Press
0022-1007
00221007
1540-9538
15409538
shingle_title_1 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
shingle_title_2 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
shingle_title_3 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
shingle_title_4 {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
timestamp 2025-06-30T23:32:37.631Z
titel {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
titel_suche {gamma}{delta} T cells provide the early source of IFN-{gamma} to aggravate lesions in spinal cord injury
topic WW-YZ
uid ipn_articles_6161222