Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews]
Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P.
The American Society for Pharmacology and Experimental Therapeutics
Published 2018
The American Society for Pharmacology and Experimental Therapeutics
Published 2018
| Publication Date: |
2018-02-09
|
|---|---|
| Publisher: |
The American Society for Pharmacology and Experimental Therapeutics
|
| Print ISSN: |
0022-3565
|
| Electronic ISSN: |
1521-0103
|
| Topics: |
Medicine
|
| Published by: |
| _version_ | 1836398785819836416 |
|---|---|
| autor | Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. |
| beschreibung | The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies have shown that capsaicin has profound antineoplastic effects in several types of human cancers. However, the applications of capsaicin as a clinically viable drug are limited by its unpleasant side effects, such as gastric irritation, stomach cramps, and burning sensation. This has led to extensive research focused on the identification and rational design of second-generation capsaicin analogs, which possess greater bioactivity than capsaicin. A majority of these natural capsaicinoids and synthetic capsaicin analogs have been studied for their pain-relieving activity. Only a few of these capsaicin analogs have been investigated for their anticancer activity in cell culture and animal models. The present review summarizes the current knowledge of the growth-inhibitory activity of natural capsaicinoids and synthetic capsaicin analogs. Future studies that examine the anticancer activity of a greater number of capsaicin analogs represent novel strategies in the treatment of human cancers. |
| citation_standardnr | 6160211 |
| datenlieferant | ipn_articles |
| feed_id | 1930 |
| feed_publisher | The American Society for Pharmacology and Experimental Therapeutics |
| feed_publisher_url | http://www.aspet.org/ |
| insertion_date | 2018-02-09 |
| journaleissn | 1521-0103 |
| journalissn | 0022-3565 |
| publikationsjahr_anzeige | 2018 |
| publikationsjahr_facette | 2018 |
| publikationsjahr_intervall | 7984:2015-2019 |
| publikationsjahr_sort | 2018 |
| publisher | The American Society for Pharmacology and Experimental Therapeutics |
| quelle | Journal of Pharmacology and Experimental Therapeutics |
| relation | http://jpet.aspetjournals.org/cgi/content/short/364/3/462?rss=1 |
| search_space | articles |
| shingle_author_1 | Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. |
| shingle_author_2 | Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. |
| shingle_author_3 | Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. |
| shingle_author_4 | Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. |
| shingle_catch_all_1 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies have shown that capsaicin has profound antineoplastic effects in several types of human cancers. However, the applications of capsaicin as a clinically viable drug are limited by its unpleasant side effects, such as gastric irritation, stomach cramps, and burning sensation. This has led to extensive research focused on the identification and rational design of second-generation capsaicin analogs, which possess greater bioactivity than capsaicin. A majority of these natural capsaicinoids and synthetic capsaicin analogs have been studied for their pain-relieving activity. Only a few of these capsaicin analogs have been investigated for their anticancer activity in cell culture and animal models. The present review summarizes the current knowledge of the growth-inhibitory activity of natural capsaicinoids and synthetic capsaicin analogs. Future studies that examine the anticancer activity of a greater number of capsaicin analogs represent novel strategies in the treatment of human cancers. Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. The American Society for Pharmacology and Experimental Therapeutics 0022-3565 00223565 1521-0103 15210103 |
| shingle_catch_all_2 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies have shown that capsaicin has profound antineoplastic effects in several types of human cancers. However, the applications of capsaicin as a clinically viable drug are limited by its unpleasant side effects, such as gastric irritation, stomach cramps, and burning sensation. This has led to extensive research focused on the identification and rational design of second-generation capsaicin analogs, which possess greater bioactivity than capsaicin. A majority of these natural capsaicinoids and synthetic capsaicin analogs have been studied for their pain-relieving activity. Only a few of these capsaicin analogs have been investigated for their anticancer activity in cell culture and animal models. The present review summarizes the current knowledge of the growth-inhibitory activity of natural capsaicinoids and synthetic capsaicin analogs. Future studies that examine the anticancer activity of a greater number of capsaicin analogs represent novel strategies in the treatment of human cancers. Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. The American Society for Pharmacology and Experimental Therapeutics 0022-3565 00223565 1521-0103 15210103 |
| shingle_catch_all_3 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies have shown that capsaicin has profound antineoplastic effects in several types of human cancers. However, the applications of capsaicin as a clinically viable drug are limited by its unpleasant side effects, such as gastric irritation, stomach cramps, and burning sensation. This has led to extensive research focused on the identification and rational design of second-generation capsaicin analogs, which possess greater bioactivity than capsaicin. A majority of these natural capsaicinoids and synthetic capsaicin analogs have been studied for their pain-relieving activity. Only a few of these capsaicin analogs have been investigated for their anticancer activity in cell culture and animal models. The present review summarizes the current knowledge of the growth-inhibitory activity of natural capsaicinoids and synthetic capsaicin analogs. Future studies that examine the anticancer activity of a greater number of capsaicin analogs represent novel strategies in the treatment of human cancers. Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. The American Society for Pharmacology and Experimental Therapeutics 0022-3565 00223565 1521-0103 15210103 |
| shingle_catch_all_4 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] The nutritional compound capsaicin is the major spicy ingredient of chili peppers. Although traditionally associated with analgesic activity, recent studies have shown that capsaicin has profound antineoplastic effects in several types of human cancers. However, the applications of capsaicin as a clinically viable drug are limited by its unpleasant side effects, such as gastric irritation, stomach cramps, and burning sensation. This has led to extensive research focused on the identification and rational design of second-generation capsaicin analogs, which possess greater bioactivity than capsaicin. A majority of these natural capsaicinoids and synthetic capsaicin analogs have been studied for their pain-relieving activity. Only a few of these capsaicin analogs have been investigated for their anticancer activity in cell culture and animal models. The present review summarizes the current knowledge of the growth-inhibitory activity of natural capsaicinoids and synthetic capsaicin analogs. Future studies that examine the anticancer activity of a greater number of capsaicin analogs represent novel strategies in the treatment of human cancers. Friedman, J. R., Nolan, N. A., Brown, K. C., Miles, S. L., Akers, A. T., Colclough, K. W., Seidler, J. M., Rimoldi, J. M., Valentovic, M. A., Dasgupta, P. The American Society for Pharmacology and Experimental Therapeutics 0022-3565 00223565 1521-0103 15210103 |
| shingle_title_1 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] |
| shingle_title_2 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] |
| shingle_title_3 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] |
| shingle_title_4 | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] |
| timestamp | 2025-06-30T23:32:36.512Z |
| titel | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] |
| titel_suche | Anticancer Activity of Natural and Synthetic Capsaicin Analogs [Minireviews] |
| topic | WW-YZ |
| uid | ipn_articles_6160211 |